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Mitochondria Na+-Ca2+ Exchange in Cardiomyocytes and Lymphocytes

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Sodium Calcium Exchange: A Growing Spectrum of Pathophysiological Implications

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 961))

Abstract

Mitochondria Na+-Ca2+ exchange (NCXmit) was first discovered by Carafoli et al. in 1974. Thereafter, the mechanisms and roles of NCXmit have been extensively studied. We review NCXmit in cardiomyocytes and lymphocytes by presenting our recent studies on it. Studies of NCXmit in rat ventricular cells demonstrated that NCXmit is voltage dependent and electrogenic. A targeted knockdown and knockout of NCLX in HL-1 cardiomyocytes and B lymphocytes, respectively, significantly reduced the NCXmit activity, indicating that NCLX is a major component of NCXmit in these cells. The store-operated Ca2+ entry was greatly attenuated in NCLX knockout lymphocytes, suggesting that substantial amount of Ca2+ enters into mitochondria and is released to cytosol via NCXmit. NCXmit or NCLX has pivotal roles in Ca2+ handling in mitochondria and cytoplasm.

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Authors and Affiliations

  1. Center for Innovation in Immunoregulative Technology and Therapeutics, Graduate School of Medicine, Kyoto University, Yoshida-konoe, Sakyo-ku, Kyoto, 606-8501, Japan

    Bongju Kim, Orie Koga, Masaki Hikida & Satoshi Matsuoka

  2. Department of Physiology and Biophysics, Graduate School of Medicine, Kyoto University, Yoshida-konoe, Sakyo-ku, Kyoto, 606-8501, Japan

    Ayako Takeuchi

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  1. Bongju Kim
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  2. Ayako Takeuchi
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  3. Orie Koga
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  4. Masaki Hikida
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  5. Satoshi Matsuoka
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Correspondence to Satoshi Matsuoka .

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Editors and Affiliations

  1. Dipto. Neuroscienze e di, Università di Napoli Fac. Medicina e Chirurgia, Napoli, Italy

    Lucio Annunziato

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Kim, B., Takeuchi, A., Koga, O., Hikida, M., Matsuoka, S. (2013). Mitochondria Na+-Ca2+ Exchange in Cardiomyocytes and Lymphocytes. In: Annunziato, L. (eds) Sodium Calcium Exchange: A Growing Spectrum of Pathophysiological Implications. Advances in Experimental Medicine and Biology, vol 961. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-4756-6_16

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