Conclusions
Disturbances in autonomic function can result in a wide variety of conditions that may ultimately culminate in the loss of consciousness. Success in identification of genes conferring susceptibility to hypotension and its clinical sequelae is expected to provide new insights into the pathophysiology of this condition and lead to development of highly accurate genetic tests, permitting identification of subjects with specific inherited susceptibility. These insights may permit intervention at preclinical stages with therapies tailored to underlying primary abnormalities, improving efficacy of treatment (nowadays, mostly empirical), and reducing morbidity from these diseases.
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References
Newton JL (2003) Prevalence of family history in vasovagal syncope and haemodynamic response to head up tilt in first degree relatives. Preliminary data for the Newcastle cohort. Clin Auton Res 13:22–26
Wieling W, Ganzeboom KS, Philip SJ (2004) Reflex syncope in children and adolescents. Heart 90:1094–1100
Kochiadakis GE, Papadimitriou EA, Marketou ME et al (2004) Autonomic nervous system changes in vasovagal syncope: Is there any difference between young and older patients? PACE 27:1371–1377
Calkins H, Byrne M, el-Atassi R et al (1993) The economic burden of unrecognized vasodepressor syncope. Am J Med 95:473–479
Camfield PR, Camfield CS (1990) Syncope in childhood: A case control clinical study of the familial tendency to faint. Can J Neurol Sci 17:306–308
Mathias C, Deguchi K, Bleasdale-Barr K, Smith S (1998) Frequency of family history in vasovagal syncope. Lancet 352:33–34
Newton JL, Kerr S, Pairman J et al (2005) Familial neurocardiogenic (vasovagal) syncope. Am J of Med Genetics 133A:176–179
Márquez MF, Urias KI, Hermosillo AG et al (2005) Familial vasovagal syncope. Europace (in press)
Lifton RP (1996) Molecular genetics of human blood pressure variation. Science 272:676–680
Cruz DN, Simon DB, Nelson-Williams C et al (2001) Mutations in the Na-Cl co transporter reduce blood pressure in humans. Hypertension 37:1458–1464
Cruz DN, Shaer AJ, Bia MJ et al (2001) Yale Gitelman’s and Bartter syndrome Collaborative Study Group. Gitelman’s syndrome revisited: A reevaluation of the symptoms and health related quality of life. Kidney Int 59:710–717
Gonzalez-Hermosillo A, Márquez MF, Kostine A et al (2004) Vasovagal syncope, orthostatic hypotension and postural orthostatic tachycardia syndrome: Is there a connection? In: Raviele A (ed) Cardiac Arrhythmias 2003. Springer, Milan, pp 615–624
Shannon JR, Flattem NL, Jordan J (2000) Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency. N Engl J Med 342:541–549
Kim CH, Zabetian CP, Cubells JF (2001) Mutations in the dopamine β-hydroxylase gene are associated with human norepinephrine deficiency. Am J Med Genet 108:140–147
Robertson D, Haile V, Perry SE et al (1991) Dopamine beta-hydroxylase deficiency. A genetic disorder of cardiovascular regulation. Hypertension 18:1–8
Streeten DHP, Kerr LP, Kerr CB et al (1972) Hyperbradykinism: A new orthostatic syndrome. Lancet II:1048–1053
DeStefano AL, Baldwin CT, Burzstyn M et al (1998) Autosomal dominant hypotensive disorder maps to chromosome 18q. Am J Hum Genet 163:1425–1430
Ranade K, Wu KD, Hwu CM et al (2001) Genetic variation in the human urea transporter is associated with variation in blood pressure. Hum Mol Genet 10:2157–2164
Mathias CJ, Bannister R (1999) Dopamine β-hydroxylase deficiency with a note on other genetically determined causes of autonomic failure. In: Mathias CJ, Bannister R (eds) Autonomic Failure. A Textbook of Clinical Disorders of the Autonomic Nervous System. Fourth edition. Oxford University Press, Oxford-New York, pp 387–401
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González-Hermosillo, A., Márquez, M.F., Vallejo, M., Urias, K.I., Cárdenas, M. (2006). Familial Vasovagal Syncope: Clinical Characteristics and Potential Genetic Substrates. In: Raviele, A. (eds) Cardiac Arrhythmias 2005. Springer, Milano. https://doi.org/10.1007/88-470-0371-7_87
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DOI: https://doi.org/10.1007/88-470-0371-7_87
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