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Past, Present, and Future Industrial Biotechnology in China

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Biotechnology in China II

Part of the book series: Advances in Biochemical Engineering / Biotechnology ((ABE,volume 122))

Abstract

Fossil resources, i.e. concentrated carbon from biomass, have been irrecoverably exhausted through modern industrial civilization in the last two hundred years. Serious consequences including crises in resources, environment and energy, as well as the pressing need for direct and indirect exploitation of solar energy, pose challenges to the science and technology community of today. Bioenergy, bulk chemicals, and biomaterials could be produced from renewable biomass in a biorefinery via biocatalysis. These sustainable industries will match the global mass cycle, creating a new form of civilization with new industries and agriculture driven by solar energy. Industrial biotechnology is the dynamo of a bioeconomy, leading to a new protocol for production of energy, bulk chemicals, and materials. This new mode of innovation will place the industry at center stage supported by universities and research institutes. Creativity in industrial biotechnology will be promoted and China will successfully follow the road to green modernization. China’s rapid economic development and its traditional capacity in fermentation will place it in an advantageous position in the industrial biotechnology revolution. The development and current status of industrial biotechnology in China are summarized herein.

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Abbreviations

β-Gase:

β-Glucosidase

AFEX:

Ammonia fiber explosion

BBCAG:

BBCA Group Co. Ltd

CBP:

Consolidated bioprocessing

CMCase:

Carboxy methyl cellulase

CNPC:

China National Petroleum Corporation

COFCO:

China Oil and Food Corporation

CRC:

China Resources (Holdings) Co. Ltd

ECUST:

East China University of Science and Technology

ED:

Entner–Doudoroff

FPase:

Filter paper digesting activity

ICGOC:

Information Center of Grain and Oil of China

ICI:

Imperial Chemical Industries

IPE-CAS:

Institute of Process Engineering, Chinese Academy of Science

MAC:

Ministry of Agriculture of China

MOST:

Ministry of Science and Technology

NBSC:

National Bureau of Statistics of China

NDRC:

National Development and Reform Commission

NJFU:

Nanjing Forestry University

SD:

Halcon Scientific Design Company

SEM:

Scanning electron microscopy

SHF:

Sequential hydrolysis and fermentation

SSCF:

Simultaneous pentose and hexose cofermentation

SSF:

Simultaneous saccharification and fermentation

TGG:

Tianguan Group Co. Ltd

talB :

Transaldolase

tktA :

Transketolase

VOCs:

Volatile organic compounds

XKS1 :

Xylulokinase

XRD:

X-ray diffraction

xylA :

Xylose isomerase

xylB :

Xylulokinase

ZSBT:

Zesheng Bioengineering Technology Co. Ltd

References

  1. Di HY (2003) Studies on vitamin C fermentation process. Tianjin University, PhD Dissertation (in Chinese)

    Google Scholar 

  2. Li GC (1997) Effects of some additives on fermentation of 2-keto-l-gulonic acid. J Microbiol 17:10, in Chinese

    Google Scholar 

  3. Wei DZ (1992) Studies on kinetic model of vitamin C: two-step fermentation process. Chin J Biotechnol 8:277, in Chinese

    CAS  Google Scholar 

  4. Chen YT (2000) Application of long-chain dicarboxylic acids. Microbiology 27(5):389, in Chinese

    Google Scholar 

  5. Xu CY, Zhuge J (2002) Advance in production of long-chain dicarboxylic acids by fermentation methods. Microbiology 22(2):66, in Chinese

    CAS  Google Scholar 

  6. Chen YT (2002) Perspective of long-chain dicarboxylic acids. Microbiology 29(2):104, in Chinese

    Google Scholar 

  7. Han Y, Lu WF, Jing YM (2001) The fermentation of long-chain dicarboxylic acids and its application downstream. Shandong Chem Ind 30(2):26, in Chinese

    Google Scholar 

  8. Ren HJ (2002) Important food additives-citric acid. Chem Technol Market 7:23, in Chinese

    Google Scholar 

  9. Yu CM, Man J (2000) General situation and prospect of citric acid production worldwide. Mod Chem Ind 11:55, in Chinese

    Google Scholar 

  10. Dong YW, Sun JH, Wang JM (2001) Application and exploitation of citric acid. Tianjin Chem Ind 17(5): 33

    Google Scholar 

  11. Wu SH, Lu M, Dong ZF (2005) Research progress on separation of citric acid from fermentation broth. J Guangxi Univ Technol 16(3):9, in Chinese

    Google Scholar 

  12. Current situation of citric acid industry, at www.chinairn.com accessed 2009.10

  13. Zheng JG, Li ZJ, Xiang SG (2006) Technique development on production process of citric acid. Hebei Chem Ind 29(9):20, in Chinese

    Google Scholar 

  14. Wang DR (2004) Development and application of sodium citrate. Chem Intermediate 8:30

    Google Scholar 

  15. Li HW, Su QH, Li ZJ, Dai LY (2005) Comprehensive report on Chinese glutamic acid production trade. J Farm Prod Proc 42(8):65, in Chinese

    Google Scholar 

  16. Zhang WG, Qian H (1997) Amino acids production technology and application. China Light Industry Press, Beijing, in Chinese

    Google Scholar 

  17. Yang F, Chen N, Zhang KX (2006) Study on the fermentation of sugarcane molasses into l-glutamic acid. Modern Food Sci Technol 22(3):45, in Chinese

    Google Scholar 

  18. Hu W (1984) The present status and recent advances in the Jingangmeisu antibiotic. Chin J Antibiot 9(2):150, in Chinese

    CAS  Google Scholar 

  19. Shen YC (1996) 25 Years research on Jingangmeisu antibiotic. Plant Prot 25(4):44, in Chinese

    Google Scholar 

  20. Yu WH (1998) Antibiotic technology. Liaoning Science and Technology Press, Liaoning, in Chinese

    Google Scholar 

  21. Zhejiang Qianjiang Biochemical Co LTD (2001) Jingangmeisu antibiotic of Qianjiang. Pesticides 40(1):40, in Chinese

    Google Scholar 

  22. Bai LQ, Li L, Xu H (2006) Functional analysis of the validamycin biosynthetic gene cluster and engineered production of validoxylamine A. Chem Biol 13:387

    Article  CAS  Google Scholar 

  23. Rong Z (2007) Developmental trend and hot events in the biochemical industry in the 21st century. Shanghai Chem Ind 32(2):27, in Chinese

    CAS  Google Scholar 

  24. Ouyang L, Xu J (2008) Progress in biocatalysis and biotransformation. Chin J Bioprocess Eng 6:1, in Chinese

    CAS  Google Scholar 

  25. Ma X, Guo D (2007) Biotransformation methods for bioactive compounds in traditional chinese medicines. Chin J Nat Med 5:162, in Chinese

    CAS  Google Scholar 

  26. Sun W (2003) Biosynthesis and biotransformation of chiral compounds. Chem Ind Market 26:5, in Chinese

    Google Scholar 

  27. Luo J, Xue J, Shen YC (2007) The R&D course of acrylamide production by biocatalysis in China. Shanghai Chem Ind 32:17, in Chinese

    CAS  Google Scholar 

  28. Zhou Y (2008) Research on optimizing the technology for producing polyacrylamide. Fine Special Chem 16(7):16, in Chinese

    Google Scholar 

  29. Li H, Su Q, Li Z (2005) Comprehensive report on Chinese glutamic acid production trade. J Farm Prod Proc 42:65, in Chinese

    Google Scholar 

  30. He V (2006) Market prospective of methionine production. Shanghai Chem Ind 31(9):51, in Chinese

    Google Scholar 

  31. Chen Y, Zhang Z, Lv H (2005) Domestic production situation of methionine and its market analysis. Fine Special Chem 13(16):22, in Chinese

    Google Scholar 

  32. Kong P (2004) Rapid development of lysine production in the world. Fine Special Chem 12(19):1, in Chinese

    Google Scholar 

  33. Wang J (2003) Status quo of lysine production and its application in China. Fine Special Chem 11(24):3, in Chinese

    CAS  Google Scholar 

  34. Deng J, Wang Z (2007) Present situation and prospectives of l-phenylalanine. Anhui Chem Ind 33(4):1, in Chinese

    CAS  Google Scholar 

  35. Zheng J, Li Z, Xiang S (2006) Technique development on production process of citric acid. Hebei Chem Ind 29(8):20, in Chinese

    Google Scholar 

  36. Liu J, Liu J, Yang L (2007) Research advancement of l-malic acid production in enzyme conversion and fermentation. China Brew 148:5, in Chinese

    Google Scholar 

  37. Xu G (2002) Commercial technology for producing 6-APA via immobilized penicillin amidase. Fine Special Chem 13:19, in Chinese

    Google Scholar 

  38. Wan D, Wang J (2003) The preparation and crystallization processes of 7-ACA. Chem Ind Eng 20:507

    Google Scholar 

  39. Dai L, Xu C, Hu C (2008) Investigation in synthesis of dane salt from d-p-hydroxyphenyl glycine from enzymatic process. Zhejiang Chem Ind 39:10, in Chinese

    Google Scholar 

  40. Li Y, Kan Z, Zhu B (2003) Advances in microbial enzymatic synthesis of d-p-hydroxyphenyl glycine. J Biol 20(6):11, in Chinese

    Google Scholar 

  41. Lu X, Zhao S, Li B (2008) Optimizing of fermentation conditions of a mixed culture in two-step fermentation of VC. Food Sci Technol 3:34, in Chinese

    Google Scholar 

  42. Cheng Y, Zhu X (2006) Progress of the research for bioconversion process of l-ascorbic acid. Hebei Chem Ind 29(3):13, in Chinese

    Google Scholar 

  43. Chang H (2004) Production of nicotinamide by microbial method. Chem Technol Market 4:24, in Chinese

    Google Scholar 

  44. Han X (2005) Production status and market analysis of d-calcium pantothenate. Fine Special Chem 13(19):28, in Chinese

    CAS  Google Scholar 

  45. Ma Y, Han C (2007) Fermentation conditions of lycopene by Blakeslea trispora. Food Res Dev 28(4):54, in Chinese

    Google Scholar 

  46. Liu H, Yu X (2007) Influences of surfactants and antioxidant on β-carotene synthesis by Blakeslea trispora. J Food Sci Biotechnol 26(2):97

    Google Scholar 

  47. Kito M, Takimoto R, Yoshida T (2002) Purification and characterization of an ε-poly-l-lysine-degrading enzyme from an ε-poly-l-lysine-producing strain of Streptomyces albulus. Arch Microbiol 178:325

    Article  CAS  Google Scholar 

  48. Zhu HY, Chen WW, Xu H, Dai SL (2005) Identification of a ε-polylysine-producing strain and study of its biosynthetic conditions. Chin J Bioprocess Eng 3(2):15, in Chinese

    CAS  Google Scholar 

  49. Zhu HY, Xu H, Wu Q, Chen WW (2005) Screening and identification of ε-PL producing strain. Microbiology 32(5):127

    CAS  Google Scholar 

  50. He BF, Wu JQ, Ouyang PK (2004) Malease catalyzed production of d-malate by coupling reaction and separation. Mod Chem Ind 24(12):27, in Chinese

    CAS  Google Scholar 

  51. Yu WB, Zhou H, Gong DC, Wei P (2005) Synthesis of β-benzyloxycarbonyl-β-propiolactone. Chem Reagent 27:735, in Chinese

    CAS  Google Scholar 

  52. Xu H, Jiang M, Li H, Lu DQ, Ouyang PK (2005) Efficient production of poly(γ-glutamic acid) by newly isolated Bacillus subtilis NX-2. Proc Biochem 40:519

    Article  CAS  Google Scholar 

  53. Wu Q, Xu H, Xu L, Ouyang PK (2006) Biosynthesis of poly(γ-glutamic acid) in Bacillus subtilis NX-2: regulation of stereochemical composition of poly(γ-glutamic acid). Proc Biochem 41:1650

    Article  CAS  Google Scholar 

  54. Wu Q, Xu H, Zhang LJ, Yao J, Ouyang PK (2006) Production, purification and properties of γ-glutamyl transpeptidase from a newly isolated Bacillus subtilis NX-2. J Mol Catal B Enzym 43:113

    Article  CAS  Google Scholar 

  55. Li S, Xu H, Jiang M (2005) Structural characteristics of exopolysaccharide produced by Alcaligenes sp. NX-3. Microbiology 36(6):37

    Google Scholar 

  56. Zhou J, Yu L (2005) Summary of low energy ion beam mediated genetic transduction. Chem Bioeng 3:1, in Chinese

    Google Scholar 

  57. Ding ZJ, Bai ZZ, Sun ZH, Ouyang PK, He BF (2004) Study on fermentative production of D(-)-lactic acid from glucose by Sporolactobacillus sp. Chin J Bioprocess Eng 2(3):30, in Chinese

    CAS  Google Scholar 

  58. He BF, Nakajima-Kambe T, Ozawa T, Nakahara T (2000) Production of d-malate and d-citramalate by Arthrobacter pascens DMDC12 having stable citraconase. Proc Biochem 36:407

    Article  CAS  Google Scholar 

  59. REN21 (2006) Renewables: Global status report (2006 Update)

    Google Scholar 

  60. Rass-Hansen J, Falsig H, Jørgensen B (2007) Bioethanol: fuel or feedstock? J Chem Technol Biotechnol 82:329

    Article  CAS  Google Scholar 

  61. Du FG, Feng WS (2006) Current development situation of fuel ethanol and its future prospects. Mod Chem Ind 26(1):6, in Chinese

    Google Scholar 

  62. Shao ZQ, Tian YS, Tan HM (2003) Pretreatment of corn stalk by steam explosion. J Beijing Inst Technol (Eng Ed) 12:85

    Google Scholar 

  63. Wang K, Wang F, Jiang JX (2007) Structure, composition and enzymatic hydrolysis of steam-exploded lespedeza stalks. For Stud China 9:137, in Chinese

    Article  CAS  Google Scholar 

  64. Sun Y, Cheng JY (2002) Hydrolysis of lignocellulosic materials for ethanol production: a review. Bioresour Technol 83:1

    Article  CAS  Google Scholar 

  65. Zhao XB, Wang L, Liu DH (2007) Effect of several factors on peracetic acid pretreatment of sugarcane bagasse for enzymatic hydrolysis. J Chem Technol Biotechnol 82:1115–1121

    Article  CAS  Google Scholar 

  66. Lu J, Shi SL, Xing XG et al (2004) Pretreatment of lignocellulose by sodium hydroxide. J Cell Sci Technol 12:1–6

    CAS  Google Scholar 

  67. Xu Z, Wang QH, Jiang ZH (2004) The study of the ammonia pretreatment effect on the enzyme hydrolysis of soybean straw to produce sugar. J Cell Sci Technol 18:773–776

    CAS  Google Scholar 

  68. Su DH, Sun JS, Liu P et al (2006) Effects of different pretreatment modes on the enzymatic digestibility of corn leaf and corn stalk. Chin J Chem Eng 14:796–801

    Article  CAS  Google Scholar 

  69. Liu G, Zhang Y, Li Y (2007) Analysis of cellulase synthesis mechanism in Trichoderma reesei using red fluorescent protein. Acta Microbiol Sin 47:69, in Chinese

    CAS  Google Scholar 

  70. Ye XY, Ng TB, Cheng KJ (2001) Purification and characterization of a cellulase from the ruminal fungus Orpinomyces joyonii cloned in Escherichia coli. Int J Biochem Cell Biol 33:87

    Article  CAS  Google Scholar 

  71. Tang X, Liu G, Tian SL (2005) Expression of the Trichoderma reesei Endoglucanse IV in Pichia pastoris. Microbiology 32:47

    CAS  Google Scholar 

  72. Liu BQ, Li XF, Gao W (2007) Study on ethanol production from biomass. Renew Energy Resour 25:54

    Google Scholar 

  73. Wang FQ, Xu P (2006) Progress on engineered strains for ethanol production. Acta Microbiol Sin 46:673, in Chinese

    CAS  Google Scholar 

  74. Cheng KK, Cai BY, Zhang JA (2008) Sugarcane bagasse hemicellulose hydrolysate for ethanol production by acid recovery process. Biochem Eng J 38:105

    Article  CAS  Google Scholar 

  75. Liu L, Sun JS (2007) The fuel ethanol production from sweet sorghum stalk. Prog Chem 19:1110

    Google Scholar 

  76. Hu M, He CY (2006) Recent advances in study of producing fuel ethanol by bio-conversion of straw. Amino Acids Biotic Resour 28:36, in Chinese

    Google Scholar 

  77. Chen HZ, Qiu WH (2007) The crucial problems and recent advances in producing fuel alcohol by fermentation of straw. Prog Chem 19:1116

    CAS  Google Scholar 

  78. Shen Y, Zhang Y, Ma T (2007) Simultaneous saccharification and fermentation of acid-pretreated corncobs with a recombinant Saccharomyces cerevisiae expressing β-glucosidase. Bioresour Technol 46:1

    Google Scholar 

  79. Ji GS, Yong Q, Yu SY (2007) Continuous fermentation of pentose/hexose mixture by immobilized yeast to prepare ethanol. Chem Ind For Prod 27:71

    CAS  Google Scholar 

  80. Hamelinck CN, van Hooijdonk G, Faaij APC (2005) Ethanol from lignocellulosic biomass: techno-economic performance in short-, middle- and long-term. Biomass Bioenergy 28:384

    Article  CAS  Google Scholar 

  81. Yang J, Wu YT, Tang XY et al (2006) Continuous ethanol fermentation–kinetic study of fermentation with pervaporation coupling system. Sichuan Chem Ind 9:13, in Chinese

    Google Scholar 

  82. Sun ZM, Jiang L, Zhang JB (2007) Industrialization course of bioconversion of fuel alcohol by cellulosic materials around the world. Liq Making Sci Technol 151:91

    Google Scholar 

  83. Yu SY (2006) Key technology of fuel ethanol from cellulose. Biomass Chem Eng 40:8

    Google Scholar 

  84. Qu YB (2007) Industrialization of cellulosic ethanol. Prog Chem 19:1098

    CAS  Google Scholar 

  85. Chen HZ, Qiu WH (2007) Key problems and progress of fuel ethanol by fermentation with straws. Prog Chem 19:1116

    CAS  Google Scholar 

  86. Li RJ (2006) Fengyuan Group Co Ltd: Innovation paved the way for success. Jiang Huai 5:14, in Chinese

    Google Scholar 

  87. Chen H, Lu SX (2007) Progress in production of fuel-ethanol from biomass resources. Petrochem Technol 36:107, in Chinese

    CAS  Google Scholar 

  88. Chen H, Lu SX (2007) Progress in production of fuel-ethanol from biomass resources. Petrochem Technol 36:107, in Chinese

    CAS  Google Scholar 

  89. Du FG, Feng WS (2006) Current development situation of fuel ethanol and its future prospects. Mod Chem Ind 26:6, in Chinese

    Google Scholar 

  90. Gu ZH (2006) Development and perspective of ethylene from ethanol. Chem Ind Eng Prog 25:847, in Chinese

    CAS  Google Scholar 

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Authors and Affiliations

  1. State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing, 210009, China

    Zhenjiang Li, Xiaojun Ji, Suli Kan, Hongqun Qiao, Min Jiang, Dingqiang Lu, Jun Wang, He Huang, Honghua Jia, Pingkai Ouyuang & Hanjie Ying

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  1. Zhenjiang Li
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  2. Xiaojun Ji
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  3. Suli Kan
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  4. Hongqun Qiao
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  5. Min Jiang
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  6. Dingqiang Lu
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  7. Jun Wang
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Corresponding authors

Correspondence to Zhenjiang Li or Pingkai Ouyuang .

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Editors and Affiliations

  1. A.A. Potter Engineering Center, Lab. Renewable Resources Engineering, Purdue University, West Lafayette, 47907, USA

    G. T. Tsao

  2. College of Life Science &, Pharmaceutical Engineering, Nanjing University of Technology, Xinmofan Road 5, Nanjing, 210009, China, People's Republic

    Pingkai Ouyang

  3. School of Biotechnology, Jiangnan University, Lihu Avenue 1800, Wuxi, 214122, China, People's Republic

    Jian Chen

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Li, Z. et al. (2010). Past, Present, and Future Industrial Biotechnology in China. In: Tsao, G., Ouyang, P., Chen, J. (eds) Biotechnology in China II. Advances in Biochemical Engineering / Biotechnology, vol 122. Springer, Berlin, Heidelberg. https://doi.org/10.1007/10_2010_76

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