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Extracellular Microvesicles (ExMVs) in Cell to Cell Communication: A Role of Telocytes

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Telocytes

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 913))

Abstract

There are several mechanisms by which cells communicate with each other. Evidence accumulates that the evolutionary oldest mechanisms of cell-cell communication involves extracellular microvesicles (ExMVs). Generally, these circular membrane fragments enriched for mRNA, miRNA, proteins, and bioactive lipids are released by exocytosis from endosomal compartment or are directly formed by budding from cell surface membranes. ExMVs from endosomal compartment called exosomes are smaller in size ~100 nM as compared to larger ones released from cell membranes that are in size up to 1 μM. In this chapter we will present an emerging link between ExMVs and recently identified novel cell-cell communication network involving a new type of cell known as telocyte. Mounting evidence accumulates that telocytes mediate several of their biological effects in several organs by releasing ExMVs enriched in mRNA, miRNA, proteins, and several biological mediators to the target cells.

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Acknowledgments

This work was supported by NIH grants 2R01 DK074720 and R01HL112788, the Stella and Henry Endowment, and Maestro grant 2011/02/A/NZ4/00035 to MZR.

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Authors and Affiliations

  1. Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, 500 S. Floyd Street, Rm. 107, Louisville, KY, 40202, USA

    Mariusz Z. Ratajczak, Daniel Ratajczak & Daniel Pedziwiatr

Authors
  1. Mariusz Z. Ratajczak
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  2. Daniel Ratajczak
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  3. Daniel Pedziwiatr
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Corresponding author

Correspondence to Mariusz Z. Ratajczak .

Editor information

Editors and Affiliations

  1. Zhongshan Hospital, Fudan University Medical School, Shanghai, China

    Xiangdong Wang

  2. Department of Cellular and Molecular Med, Carol Davila Univ of Medicine&Pharmacy, Bucharest, Romania

    Dragos Cretoiu

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© 2016 Springer Science+Business Media Singapore

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Ratajczak, M.Z., Ratajczak, D., Pedziwiatr, D. (2016). Extracellular Microvesicles (ExMVs) in Cell to Cell Communication: A Role of Telocytes. In: Wang, X., Cretoiu, D. (eds) Telocytes. Advances in Experimental Medicine and Biology, vol 913. Springer, Singapore. https://doi.org/10.1007/978-981-10-1061-3_3

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