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Macrophages in the Uterus and Placenta

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Macrophage Biology and Activation

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 181))

Abstract

Macrophages are abundant in the mesenchymal and connective tissue stroma of the cycling and pregnant uterus, and constitute a significant proportion of the villous or labyrinthine mesenchymal cells in the human and murid placenta. In other contexts, the activities of these multifunctional cells are strongly influenced by regulatory molecules such as steroid hormones, polypeptide growth factors, and bioactive lipids. All of these are present at particularly high concentrations in the pregnant uterus and placenta. Thus, uterine and placental macrophages stimulated by endogenous factors could contribute to the complex cellular and molecular interactions that result in successful pregnancy.

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Authors and Affiliations

  1. Department of Pathology and Oncology, University of Kansas Medical Center, 39th Street and Rainbow Boulevard, Kansas City, Kansas, 66103, USA

    J. S. Hunt

  2. Department of Developmental Biology and Cancer and Department of Obstetrics and Gynecology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York, 10461, USA

    J. W. Pollard

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  1. J. S. Hunt
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Editors and Affiliations

  1. University of Kansas Cancer Ctr., Kansas City, KA, 66160-7312, USA

    Stephen W. Russell (Wilkinson Distinguished Professor and Director) (Wilkinson Distinguished Professor and Director)

  2. Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK

    Siamon Gordon

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© 1992 Springer-Verlag Berlin Heidelberg

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Hunt, J.S., Pollard, J.W. (1992). Macrophages in the Uterus and Placenta. In: Russell, S.W., Gordon, S. (eds) Macrophage Biology and Activation. Current Topics in Microbiology and Immunology, vol 181. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77377-8_2

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  • DOI: https://doi.org/10.1007/978-3-642-77377-8_2

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