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Structure-Function Studies on PEDF

A Noninhibitory Serpin with Neurotrophic Activity

  • Chapter
Chemistry and Biology of Serpins

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 425))

Abstract

Pigment epithelium-derived factor (PEDF) is a neurotrophic factor. In vitro it induces neuronal differentiation of retinoblastoma cells and promotes survival of cerebellar granule cell neurons. By virtue of amino acid sequence homology PEDF is a unique serpin member.

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Author information

Authors and Affiliations

  1. Laboratory of Retinal Cell and Molecular Biology, National Eye Institute National Institutes of Health, Building 6, room 308 6 Center Dr. MSC 2740, Bethesda, Maryland, 20892-2740, USA

    S. Patricia Becerra

Authors
  1. S. Patricia Becerra
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Editor information

Editors and Affiliations

  1. University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA

    Frank C. Church

  2. University of California, Irvine, California, USA

    Dennis D. Cunningham

  3. Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, Michigan, USA

    David Ginsburg

  4. Duke University and Durham VA Medical Centers, Durham, North Carolina, USA

    Maureane Hoffman

  5. Late of Monash University, Clayton, Victoria, Australia

    Stuart R. Stone

  6. Washington University School of Medicine, St. Louis, Missouri, USA

    Douglas M. Tollefsen

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© 1997 Springer Science+Business Media New York

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Becerra, S.P. (1997). Structure-Function Studies on PEDF. In: Church, F.C., Cunningham, D.D., Ginsburg, D., Hoffman, M., Stone, S.R., Tollefsen, D.M. (eds) Chemistry and Biology of Serpins. Advances in Experimental Medicine and Biology, vol 425. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5391-5_21

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  • DOI: https://doi.org/10.1007/978-1-4615-5391-5_21

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7461-9

  • Online ISBN: 978-1-4615-5391-5

  • eBook Packages: Springer Book Archive

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