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Induction and Evasion of the Type I Interferon Response by Cytomegaloviruses

  • Conference paper
Current Topics in Innate Immunity

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 598))

Abstract

Cytomegaloviruses represent supreme pathogens in that they are capable of occupying healthy mammalian hosts for life in the face of constant antiviral immune reactions. The inability of the host to eliminate the virus likely results from numerous counteractive strategies employed to disrupt the immune response. The role of type I interferon in the antiviral response has been well documented although only recently have the pathways of induction of this powerful cytokine been described. Cytomegaloviruses have been shown to both induce and be sensitive to the effects of type I interferon. Yet these viruses also possess numerous and varied phenotypes capable of inhibiting not only interferon induction but also interferon signaling and interferon-induced antiviral processes. The balance between induction and evasion of type I interferon responses by cytomegaloviruses is discussed in this review.

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Authors and Affiliations

  1. Vaccine and Gene Therapy Institute, Oregon Health and Science University, Oregon

    Victor R. DeFilippis

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  1. Victor R. DeFilippis
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  1. Department of Pathology & Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    John D. Lambris

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DeFilippis, V.R. (2007). Induction and Evasion of the Type I Interferon Response by Cytomegaloviruses. In: Lambris, J.D. (eds) Current Topics in Innate Immunity. Advances in Experimental Medicine and Biology, vol 598. Springer, New York, NY. https://doi.org/10.1007/978-0-387-71767-8_22

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