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Triggered Phagocytosis by Salmonella: Bacterial Molecular Mimicry of RhoGTPase Activation/Deactivation

  • Chapter
Bacterial Virulence Factors and Rho GTPases

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 291))

Abstract

Salmonella Typhimurium uses the type III secretion system encoded in the Salmonella pathogenicity island I (SPI-1 TTSS) to inject toxins (effector proteins) into host cells. Here, we focus on the functional mechanism of three of these toxins: SopE, SopE2, and SptP. All three effector proteins change the GTP/GDP loading state of RhoGTPases by transient interactions. SopE and SopE2 mimic eukaryotic G-nucleotide exchange factors and thereby activate RhoGTPase signaling pathways in infected host cells. In contrast, a domain of SptP inactivates RhoGTPases by mimicking the activity of eukaryotic GTPase-activating proteins. The Salmonella-host cell interaction provides an excellent example for the use of molecular mimicry by bacterial pathogens.

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Authors and Affiliations

  1. Institute of Microbiology, ETH Zürich, Wolfgang-Pauli-Strasse 10, 8093, Zürich, Switzerland

    M. C. Schlumberger & W.-D. Hardt

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  1. M. C. Schlumberger
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  2. W.-D. Hardt
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Editors and Affiliations

  1. Faculty of Medicine, INSERM U627, IFR 50, 28, Avenue de Valombrose, Nice, France

    Patrice Boquet (Professor Dr.) & Emmanuel Lemichez (Professor Dr.) (Professor Dr.) &  (Professor Dr.)

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Schlumberger, M.C., Hardt, WD. (2005). Triggered Phagocytosis by Salmonella: Bacterial Molecular Mimicry of RhoGTPase Activation/Deactivation. In: Boquet, P., Lemichez, E. (eds) Bacterial Virulence Factors and Rho GTPases. Current Topics in Microbiology and Immunology, vol 291. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27511-8_3

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