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MSC and Tumors: Homing, Differentiation, and Secretion Influence Therapeutic Potential

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Mesenchymal Stem Cells - Basics and Clinical Application II

Part of the book series: Advances in Biochemical Engineering/Biotechnology ((ABE,volume 130))

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Abbreviations

5-FC:

5-Fluorocytosine

AAV:

Adeno associated viruses

APC:

Antigen presenting cells

Ang-1:

Angiopoietin 1

bFGF:

Basic fibroblast growth factor

BM:

Bone marrow

BrdUrd:

Bromodeoxyuridine

c-fibronectin:

Cellular fibronectin

CSC:

Cancer stem cells

CTL:

Cytotoxic T Lymphocytes

DC:

Dendritic cells

DKK-1:

Dickkopf-related protein-1

DL:

Death ligand

ECM:

Extracellular matrix

EGF:

Epidermal growth factor

EMT:

Epithelial to mesenchymal transition

EndMT:

Endothelial to mesenchymal transition

EPC:

Endothelial progenitor cells

ESC:

Embryonic stem cell

ET-1:

Endothelin-1

ETBR:

Endothelin binding receptor

FAK:

Focal adhesion kinase

FAP:

Fibroblast activation protein

FPRL-1:

Formyl peptide receptor like-1

FSP:

Fibroblast specific protein

G-CSF:

Granulocyte-colony-stimulating factor

GM-CSF:

Granulocyte-macrophage-colony-stimulating factor

hAD-MSC:

Human adipose-derived mesenchymal stromal/stem cells

hBM-MSC:

Human bone marrow-derived mesenchymal stromal/stem cells

HCC:

Hepatocarcinoma cancer

HGF:

Hepatocyte growth factor

HLA:

Human leukocyte antigen

HLA-DR:

Human leukocyte antigen and its ligand

hMSC:

Human mesenchymal stromal/stem cells

HO-1:

Heme oxygenase-1

HSC:

Hematopoietic stem cells

IDO:

Indolamin 2, 3-dioxygenase

IFN-γ:

Interferon-gamma

IGF:

Insulin growth factor

IL:

Interleukin

LIF:

Leukemia inhibitory factor

MCP-1/CCL5:

Monocyte chemotactic protein-1

M-CSF:

Macrophage-colony-stimulating factor

MDSCs:

Myeloid derived suppressor cells

miRNA:

microRNA

MMP:

Matrix metalloproteinases

MSC:

Mesenchymal stromal/stem cells

NF-κB:

Nuclear factor-kappa B

NHL:

non-Hodgkin lymphoma

NK cells:

Natural killer cells

NO:

Nitric oxide

NSCLC:

Non-small cell lung carcinoma

OI:

Osteogenesis imperfecta

PAI-1:

Plasminogen activator inhibitor type-1

PAI-2:

Plasminogen activator inhibitor type-2

PDGF:

Platelet derived growth factor

p-fibronectin:

Plasma fibronectin

PGE2:

Prostaglandin E2

PIFA:

Platinum-induced polyunsaturated fatty acids

PlGF:

Placental growth factor

ROS:

Reactive oxygen species

SCID:

Severe combined immunodeficieny

SDF-1/CXCL12:

Stromal derived factor–1

sHLA-G5:

Soluble human leukocyte antigen G5

SL-1:

Stromelysin-1

STC1:

Stanniocalcin-1

S-TRAIL:

Secretable form of TRAIL

TAF/CAF:

Tumor-associated fibroblasts/carcinoma associated fibroblasts

TAM:

Tumor-associated macrophages

TGF-β:

Transforming growth factor-beta

Th1 cells:

T Helper 1 cells

Th2 cells:

T Helper 2 cells

TIMPs:

Tissue inhibitor of metalloproteinases

TLS:

Tertiary lymphoid structures

Tn-C:

Tenascin-C

TNF:

Tumor necrosis factor

TNF-α:

Tumor necrosis factor-alpha

tPA:

Tissue plasminogen activator

TRAIL:

Tumor necrosis factor apoptosis inducing ligand

Tregs:

T regulatory cells

Tsp-1:

Thrombospondin-1

uPA:

Urokinase plasminogen activator

uPAR:

Urokinase plasminogen activator receptor

VEGF:

Vascular endothelial growth factor

WAT:

White adipose tissue

α-SMA:

Alpha-smooth muscle actin

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Acknowledgments

This work was supported by: Ministero Italiano Istruzione Università e Ricerca-PRIN 2008 (MD, PP), Ministero Italiano della Salute-Bando Giovani Ricercatori (MD), Regione Emilia Romagna (PP, PC, MD), the Associazione ASEOP (PP) and Fondazione Cassa di Risparmio di Modena (MD).

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Authors and Affiliations

  1. Department of Medical and Surgical Sciences for Children & Adults, University Hospital of Modena and Reggio Emilia, Via del Pozzo, 71, 41100, Modena, Italy

    Naomi D’souza, Jorge Sans Burns, Giulia Grisendi, Olivia Candini, Elena Veronesi, Serena Piccinno, Paolo Paolucci, Pierfranco Conte & Massimo Dominici

  2. Division of Oncology, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA

    Edwin M. Horwitz

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  1. Naomi D’souza
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Correspondence to Massimo Dominici .

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Editors and Affiliations

  1. Abt. für Plastische und Handchirurgie, Medizinische Hochschule Hannover, Hannover, Germany

    Birgit Weyand

  2. Integrated Department of Oncology, Haematology and Respiratory Diseases, University of Modena and Reggio Emilia, Modena, Italy

    Massimo Dominici

  3. Medizinische Hochschule Hannover, AG Biochemie und Tumorbiologie, Klinik für Frauenheilkunde und Geburtshilfe, Hannover, Germany

    Ralf Hass

  4. Medizinische Hochschule Hannover, Klinik für Immunologie und Rheumatologie, Hannover, Niedersachsen, Germany

    Roland Jacobs

  5. Department für Biotechnologie, Universität für Bodenkultur, Wien, Austria

    Cornelia Kasper

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D’souza, N. et al. (2012). MSC and Tumors: Homing, Differentiation, and Secretion Influence Therapeutic Potential. In: Weyand, B., Dominici, M., Hass, R., Jacobs, R., Kasper, C. (eds) Mesenchymal Stem Cells - Basics and Clinical Application II. Advances in Biochemical Engineering/Biotechnology, vol 130. Springer, Berlin, Heidelberg. https://doi.org/10.1007/10_2012_150

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