Overview
- Editors:
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Lee-Jun C. Wong
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Molecular Diagnostic Laboratory, Baylor College of Medicine, Houston, USA
- Will cover the diagnostic yields of various Next Generation Sequencing applications
- Readers will learn the advantages and disadvantages of panels and whole exome sequencing as it relates to human genetic disease
- Includes a look at future medically relevant exomes
- Includes supplementary material: sn.pub/extras
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Table of contents (17 chapters)
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Front Matter
Pages i-viii
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- Yanming Feng, David Chen, Lee-Jun C. Wong
Pages 13-22
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- Elizabeth B. Gorman, Lee-Jun C. Wong
Pages 23-49
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- Xia Wang, Richard Alan Lewis
Pages 51-69
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- Xinjian Wang, Lisa Dyer, Kejian Zhang, John Greinwald Jr., C. Alexander Valencia
Pages 71-87
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- Lijun Wang, C. Alexander Valencia, Rebecca A. Marsh, Kejian Zhang
Pages 89-112
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- Allison Tam, Victor Wei Zhang, Lee Jun Wong, Sandesh C. S. Nagamani
Pages 113-121
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- Holly LaDuca, Shuwei Li, A. J. Stuenkel, Virginia Speare, Jill S. Dolinsky, Elizabeth C. Chao
Pages 123-153
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- Hui Mei, Hongzheng Dai, Jinglan Zhang, Lee-Jun Wong, Pilar L. Magoulas
Pages 155-176
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- Lijun Wang, Arunkanth Ankala, Hamoud Al Khallaf, Xinjian Wang, Mikhail Martchenko, Biao Dong et al.
Pages 177-200
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- Amy E. Knight Johnson, Siri Atma W. Greeley, Daniela del Gaudio
Pages 201-242
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- Guoliang Wang, Vivan Niewiadonski, Jianping Li, Ruirui Ji, Wenxin Zou, Daniel J. Penny et al.
Pages 243-286
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- Victor Wei Zhang, Lee-Jun C. Wong
Pages 287-304
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- Theodore Chiang, Magalie Leduc, Mari Tokita, Teresa Santiago-Sim, Yaping Yang
Pages 305-320
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- Xia Wang, Linyan Meng, Magalie S. Leduc
Pages 321-338
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- Anastasia Fedick, Jinglan Zhang
Pages 339-354
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- Lisa Dyer, Xinjian Wang, Kejian Zhang, John Greinwald Jr., C. Alexander Valencia
Pages E1-E1
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Back Matter
Pages 355-364
About this book
Next Generation Sequencing technology has been applied to clinical diagnoses in the past three to five years using various approaches, including target gene panels and whole exomes. The purpose of this book is to summarize the experiences, the results, advantages and disadvantages, along with future development in the area of NGS-based molecular diagnosis. This up-to-date volume will not only provide the readers working with Next Generation Sequencing the basics on how to apply the technology to molecular diagnosis, but will present the results and experience of practical application.
Editors and Affiliations
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Molecular Diagnostic Laboratory, Baylor College of Medicine, Houston, USA
Lee-Jun C. Wong
About the editor
Dr. Wong received her BS in Biochemistry from National Taiwan University and her Ph.D. in Chemistry from the Ohio State University. She did her postdoctoral training in biochemical sciences at Fox Chase Cancer Center in Philadelphia, with the Nobel Laureate Dr. Irwin Rose, and at Princeton University with Dr. Bruce Alberts, the past president of the US National Academy of Science. She became involved in genetics and received further training at Baylor College of Medicine. She is certified by the American Board of Medical Genetics in the specialty areas of Clinical Molecular Genetics and Biochemical Genetics. Dr. Wong served as the Director of the Molecular Diagnostic Laboratory at Childrens Hospital Los Angeles and Georgetown University for 10 years before rejoining Baylor College of Medicine as a professor in the Department of Molecular and Human Genetics. There she heads the Mitochondrial/Metabolic Molecular Diagnostic Laboratory. Dr. Wong's research focuses on mitochondrialgenetics and function in disease, aging, and cancer. She has published over 250 peer-reviewed articles, 13 book chapters, and edited 3 books.
