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Colon Cancer Prevention

Dietary Modulation of Cellular and Molecular Mechanisms

  • Book
  • © 1999

Overview

Editors:
  1. American Institute for Cancer Research

    1. USA

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 470)

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-viii
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  2. Transcriptional Regulation in Intestinal Development

    • Peter G. Traber
    Pages 1-14

  3. Colonic Cell Proliferation, Differentiation, and Apoptosis

    • Leonard Augenlicht, Anna Velcich, John Mariadason, Michael Bordonaro, Barbara Heerdt
    Pages 15-22

  4. Defects in the Regulation of β-Catenin in Colorectal Cancer

    • Paul Polakis, Matt Hart, Bonnee Rubinfeld
    Pages 23-32

  5. Dietary Lipids, Inflammation, and Colon Cancer

    • Connye N. Kuratko
    Pages 33-43

  6. Sulindac Sulfone Induced Regression of Rectal Polyps in Patients with Familial Adenomatous Polyposis

    • G. D. Stoner, G. T. Budd, R. Ganapathi, B. De Young, L. A. Kresty, M. Nitert et al.
    Pages 45-53

  7. Prevention of Colon Cancer and Modulation of Aberrant Crypt Foci, Cell Proliferation, and Apoptosis by Retinoids and NSAIDs

    • Michael A. Pereira
    Pages 55-63

  8. Digested Fiber from Wheat Bran Induces cdk Inhibitors which Block Colon Epithelial Cells in G1

    • Eileen A. Friedman, Jingping Wang
    Pages 65-76

  9. Mechanisms by which Energy Restriction Inhibits Carcinogenesis

    • Henry J. Thompson, Weiqin Jiang, Zongjian Zhu
    Pages 77-84

  10. Dietary Intervention Studies of Colorectal Cancer

    • Arthur Schatzkin
    Pages 85-93

  11. The Genetics of Hereditary Non-Polyposis Colorectal Cancer and Non-Polypotic Colon Cancer

    • Päivi Peltomäki
    Pages 95-98

  12. Familial Association

    • Randall W. Burt
    Pages 99-104

  13. Colonic Cell Proliferation and Apoptosis in Rodent Species

    • Robert S. Chapkin, Joanne R. Lupton
    Pages 105-118

  14. Nonsteroidal Anti-Inflammatory Drugs (NSAIDs), Cyclooxygenases, and the Cell Cycle

    • Basil Rigas, Steven J. Shiff
    Pages 119-126

  15. Back Matter

    Pages 163-165
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Keywords

About this book

The Eighth Annual Research Conference of the American Institute for Cancer Research, held in Washington, D.C., September 3-4, 1998, was on the subject "Colon Cancer Prevention: Dietary Modulation of Cellular and Molecular Mechanisms," with participants representing various disciplines interested in this area. One of the speak­ ers provided an appropriate quote from 17th century physician Thomas Adams: "Pre­ vention is better than healing because it saves the labor of being sick," which aptly describes the need for the prevention of cancer. An overview of normal and abnormal colonic development emphasized that although the typical human colon undergoes 1013 cell divisions by age 60, with the asso­ ciated possibilities for error, relatively few colon tumors develop. Since dietary modu­ lation leads to extremely small changes in colonic cells over a long period, animal models are useful to time, observe, and delineate the events associated with colon cancer. In the development colon cancer, the inactivation of the adenomatous polyposis coli (Apc) gene is one of the earliest known events. Normally Apc downregulates the cellular protein beta-catenin, but this is lost during cancer development. Beta-catenin may itself be an oncogene; it has a short half-life, but it is stabilized by binding to is more prevalent in the cell nucleus, the gene shuttles caherin. Although the Apc between the nucleus and the cytoplasm.

Editors and Affiliations

  • USA

    American Institute for Cancer Research

Bibliographic Information

  • Book Title: Colon Cancer Prevention

  • Book Subtitle: Dietary Modulation of Cellular and Molecular Mechanisms

  • Editors: American Institute for Cancer Research

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4615-4149-3

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1999

  • Hardcover ISBN: 978-0-306-46207-8Published: 29 February 2000

  • Softcover ISBN: 978-1-4613-6861-8Published: 27 September 2012

  • eBook ISBN: 978-1-4615-4149-3Published: 06 December 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: VIII, 165

  • Topics: Cancer Research, Oncology, Anatomy

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