Abstract
Background
Little is known about female sexual function and interstitial lung disease (ILD). The purpose of this study was to evaluate sexual function and depression in married women with ILD.
Patients and methods
Of the 65 participants enrolled, 45 patients with ILD fulfilled the inclusion criteria, comprising 12 patients with idiopathic pulmonary fibrosis, 25 with connective tissue disease-associated interstitial pneumonias, eight patients with other interstitial pneumonias. Moreover, 20 age-matched normal individuals were recruited as controls. All participants were evaluated for clinical data, including age, BMI, comorbidities, duration of ILD, usage of glucocorticoids (dose and duration), and number of exacerbation within the past year. All women fulfilled the female sexual function index (FSFI) and Beck depression inventory.
Results
The mean age of the ILD group was 40.4±8.9 years. Overall, 33.3% were hypertensive and 53.3% had pulmonary hypertension, whereas diabetes mellitus and dyslipidemia were found in 26.6 and 15.5%, respectively. The mean duration since diagnosis of ILD and using glucocorticoids was 8.46±2.77 and 9.23±2.31 years. No differences in forced vital capacity and forced expiratory volume in 1 s were observed. There was a significant decrease in mean diffusion capacity (diffusion lung capacity for carbon monoxide) (61.8±7.10 vs. 68.7±6.86%) when compared with control (P=0.000*). Using FSFI, there was a significant decrease in global FSFI score and each domain in patients with ILD as compared with control (P=0.000*). The overall prevalence of depression was 80%. Correlation was found between total FSFI and disease duration, duration of glucocorticoids and dosage (≥20 mg), and depression (Beck depression inventory).
Conclusion
Despite mild impairment in pulmonary function, female patients with ILD have reported sexual dysfunction and increased depression. Thus, physicians should be reminded that patients with ILD need a comprehensive evaluation for sexual function.
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References
Cushley MJ, Davison AG, DuBois RM. The diagnosis, assessment and treatment of diffuse parenchymal lung disease in adults:British Thoracic Society recommendations. Thorax 1999; 54(Suppl 1):S1–S28.
King TE. Clinical advances in the diagnosis and therapy of interstitial lung diseases. Am J Respir Crit Care Med 2005; 172:268–279.
Basson R, Leiblum S, Brotto L. Revised definitions of women’s sexual dysfunction. J Sex Med 2004; 1:40–48.
Verschuren JE, Enzlin P, Dijkstra PU, Geertzen JH, Dekker R. Chronic disease and sexuality:a generic conceptual framework. J Sex Res 2010; 47:153–170.
Tomioka H, Imanaka K, Hashimoto K, Iwasaki H. Health-related quality of life in patients with idiopathic pulmonary fibrosis – cross-sectional and longitudinal study. Intern Med 2007; 46:1533–1542.
Travis WD, Costabel U, Hansell DM. An official American Thoracic Society/European Respiratory Society statement:update of the international multidisciplinary classification of the idiopathic interstitial pneumonias. Am J Respir Crit Care Med 2013; 188:733–748.
Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, et al. ATS/ERS Task Force General considerations for lung function testing. Eur Respir J 2005; 26:153–161.
Macintyre N, Crapo RO, Viegi G, Johnson DC, van der Grinten CP. Standardisation of the single-breath determination of carbon monoxide uptake in the lung. Eur Respir J Off J Eur Soc Clin Respir Physiol 2005; 26:720–735.
Rosen RC, Brown C, Heiman J, Leiblum S, Meston C, Shabsigh R, et al. The female sexual function index (FSFI):a multidimensional self report instrument for the assessment of female sexual function. J Sex Marital Ther 2000; 26:191–208.
Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J. An inventory for measuring depression. Arch Gen Psychiatry 1961; 4:561–571.
Bachmann GA, Avci D. Evaluation and management of female sexual dysfunction. Endocrinologist 2004; 14:337–345.
Nusbaum MR, Hamilton C, Lenahan P. Chronic illness and sexual functioning. Am Fam Physician 2003; 67:347–354.
Goodell TT. Sexuality in chronic lung disease. Nurs Clin North Am 2007; 42:631–638.
Schönhofer B, Von Sydow K, Bucher T, Nietsch M, Suchi S, Köhler D, et al. Sexuality in patients with noninvasive mechanical ventilation due to chronic respiratory failure. Am J Respir Crit Care Med 2001; 164:1612–1617.
Steinke EE. Sexuality and chronic illness. J Gerontol Nurs 2013; 39:18–27. quiz 28–29
Collins EG, Halabi S, Langston M, Schnell T, Tobin MJ, Laghi F. Sexual dysfunction in men with COPD:impact on quality of life and survival. Lung 2012; 190:545–556.
Thombs BD, Taillefer SS, Hudson M, Baron M. Depression in patients with systemic sclerosis:a systematic review of the evidence. Arthritis Rheum 2007; 57:1089–1097.
Roca RP, Wigley FM, White B. Depressive symptoms associated with scleroderma. Arthritis Rheum 1996; 39:1035–1040.
Schouffoer AA, van der Marel J, Ter Kuile MM. Impaired sexual function in women with systemic sclerosis:a cross-sectional study. Arthritis Care Res 2009; 61:1601–1608.
Guerriere JA, Rosen RC, Seibold JR. Quality of life and sexual function in women with systemic sclerosis (SSc). Arthritis Rheum 2001; 9(44 Suppl):S328.
Faubion SS, Rullo JE. Sexual dysfunction in women:a practical approach. Am Fam Physician 2015; 92:281–288.
Sharma JB, Kalra B. Female sexual dysfunction:assessment. J Pak Med Assoc 2016; 66:623–626.
Gellad WF, Flynn KE, Alexander GC. Evaluation of flibanserin:science and advocacy at the FDA. JAMA 2015; 314:869–870.
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Magdy, D.M., Metwally, A. & El Zohne, R.A. Evaluation of sexual function and depression in married women with interstitial lung diseases. Egypt J Bronchol 13, 358–362 (2019). https://doi.org/10.4103/ejb.ejb_91_18
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DOI: https://doi.org/10.4103/ejb.ejb_91_18