Abstract
The recent development of the analytical techniques offers the unprecedented possibility to study simultaneously concentration of dozens of elements in the same biological matrix sample of 0.5–1.0 g (multielement profiles). The first part of this essay entitled “Think globally… An outline of trace elements in health and disease” aims to introduce the reader to the fascinating field of elements, there importance to our nutrition, their essentiality, deficiency, toxicity and bioavailability to the body and their overall role in health and disease, including the genetic metabolic impairments. In the second part of the essay entitled “… and act locally. The multielement profile of depression” we aimed to show the potential of such a hair multielement profile analysis for the study of human depression in a randomized, double blind, prospective, observational, cross-sectional, clinical, epidemiological, and analytical study. The preliminary results of this ongoing study lead us to put forward the hypothesis that the metabolic origin of depression may be due to some “energostat” failure, probably located in the thalamus, and activated by several essential element deficiencies.
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References
Frausto de Silva J.J.R., Williams R.J.P., The biological chemistry of the elements, Claredon Press, Oxford, UK 1991.
Emsley J., Nature’s building blocks, Oxford University Press, Oxford, UK 2001.
Ninham B.W., Lo Nostro P., Molecular forces and self-assembly, Cambridge University Press, Cambridge, UK 2010.
Besant A., Leadbeater C.W., Occult chemistry, 3rd e., The Theosophical Publishing. Co., Wheaton, IL, USA 2003.
Momčilović B., Novel visualization of the periodic system of elements. The orthogonal dimension, Trace Elem Med (Moscow), 2007; 8(4):1–6.
Levander O.A., Cheng L., Micronutreient interactions, vitamins, minerals, and hazardous elements, Proceedings of the New York Academy of Sciences, New York, USA 1980, Vol. 355.
Momčilović B., Reeves P., Blake M.J., Idiorrhythmic dose-rate variability in dietary zinc intake generates a different response pattern of zinc metabolism than conventional dose-response feeding, Brit J Nutr 1997; 78:173–191.
Underwood E.J., Trace elements in human and animal nutrition, Academic Press, New York, USA 1977.
Momčilović B., Lykken G.I., Ivičić N., Prejac J., Low serum ferritin slowed 54Mn gastrointestinal transit time in women fed low manganese diet, Trace Elem Electroly 2009; 26:131–136.
National Academy Press, Dietary reference intakes for vitamin C, vitamin E, selenium, and carotenoids, National Academy of Sciences, Washington, DC., USA 2000.
National Academy Press, Dietary reference intakes for vitamin A, vitamin K, arsen, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc, National Academy of Sciences, Washington, DC., USA 2001.
Shills M.E., Shike M., Ross A.C., Caballero B., Cousins R.J. (eds.), Modern nutrition in health and disease, Lippinccott Williams and Wilkins, Baltimore, MD, USA 2006.
World Health Organization (WHO), Trace elements in human nutrition and health, WHO, Geneva, Switzerland 1996.
Merian E., Anke M., Ihnat M., Stoeppler M., Elements and their compounds in the environment, 2nd ed., Vol. 2, of three volume set Metals and their compounds, Wiley-VCH, Weinheim, Germany 2006.
Reilly C., Metal contamination of food. Its significance for food quality and human health, 3rd ed., Blackwell Science Ltd., Oxford, UK 2002.
Sarkar B. (ed.), Heavy metals in the environment, Marcel Dekker, Inc., New York, NY, USA 2002.
Harbison R.D., Hamilton & Harddy’s industrial toxicology, 5th ed., Mosby, St Louis, 1998.
Hayes A.W. (ed.), Metals, in Principles and methods of toxicology, 4th ed. Taylor and Francis, London, UK 2001:649–698.
Guy R.H., Hostynek J.J., Hinz R.S., Lorence C.R., Metals and the skin, Marcel Dekker, Inc., New York, USA 1999.
Momčilović B., The epistemology of trace element balance and interactions, Plenary Lecture, 6th International Symposium on Trace Elements in Man and Animals 6 (TEMA 6), Plenum Press New York, USA 1987:173–177.
Hordinsky M.K., Alopecia, in Dermatology (Bolognia J.L., Jorizzo J.L., Rapini R.P., eds.), Mosby, Edinburgh, UK 2003:1033–1059.
Burgess C., Valid analytical methods and procedures, Royal Society of Chemistry, Cambridge, UK 2000.
Passwater R.A., Cranton E.M., Trace element hair analysis, and nutrition, New Cannan, CT, Keats Publishing Inc., USA 1983.
Chatt A., Katz S.A., Hair analysis, VCH Publishing Inc., New York, USA 1988.
Cutler A.H., Hair test interpretation. Finding the hidden toxicities, Amazon.com 2010.
Wilson L.D., Nutritional balance and hair mineral analysis, Amazon.com 2010.
Momčilović B., Multielementni profil kose, in Trihologija (Šitum M. and Oremović L., eds), Naklada Slap, Jastrebarsko, Croatia 2007:35–55.
Momčilović B., A case report of acute human molybdenum toxicity from a dietary molybdenum supplement — A new member of the “Lucor metallicum” family, Arh Hig Rada Toksikol 1999; 50:289–297.
Chwastiak L., Katon W., Anxiety and depression, in Oxford Textbook of Medicine (Warrell DA, Cox TM, Firth JD, eds.), 4th ed., Vol. 3, Oxford University Press, Oxford, UK 2003:1303–1309.
Licino J., Wong M-L. (eds.), Biology of depression, Vol. 1 and 2, Wiley-VCH Weinheim, Germany 2005.
Momčilović B., Morović J., Skalny A.V., Ivičić N., Hair and blood multielement profile for metabolic imaging of the major human depression. Study rationale and design, Trace Elem Med (Moscow), 2006; 7(4):15–22.
American Psychiatric Association (APA), The diagnostic and statistical manual of mental disorders, 4th ed., Text revision (DSM-IV-TR), APA, Washington, DC., USA 2000.
Momčilović B., Poremećaj prometa elemenata u tragovima, in Patofiziologija (Gamulin S., Marušić M., Kovač Z., eds.), 8th ed., Vol.1., Ch.7.4, Medicinska naklada, Zagreb, Croatia 2011:258–264.
Momčilović B., Lykken G.I., Morović J., Skalny A.V., Ivičić N., Multielement hair profile for early detection of bone osteoporosis in men and women, Trace Elem Med (Moscow) 2006; 7(1):41.
Sterner R.W., Elser J.J., Ecological stoichiometry. The biology of elements from molecules to the biosphere, Princeton University Press, Princeton, NJ, USA 2002.
Momčilović B., Morović J., Ivičić N., Skalny A.V., Skalnaya M.G., Grebaklis A.R., Increased hair mercury is associated with the low iodine but variable selenium concentrations, 8th International Conference on Mercury as a Global pollutant, Madison, Wisconsin, USA, Aug -6–11, 2006 Abstract 208.
Biesalski H.K., Grimm P., Pocket atlas of nutrition, Thieme, Stutgart, Germany 2005:236.
Momčilović B., Morović J., Prejac J., Skalnaya M.G., Ivičić N., Relationship of iodine, selenium and copper in the hair and whole blood of depressed human subjects, Trace Elem Electroly 2008; 25:195–198.
Bubl E., Tebartz van Elst L., Gondan M., Ebert D., Greenlee M.W., Vision in depressive disorder, World J Biol Psychiatr 2009; 10:377–384.
Negoias S., Croy I., Gerger J., Puschmann S., Petrowski K., Joraschky P., Hummel T., Reduced olfactory bulb volume and olfactory sensitivity in patients with acute major depression, Neuroscience 2010; 169:415–421.
Nriagu J.O. (ed.), Zinc in the environment, Part 2, John Wiley and Sons, New York, USA 1980.
Van Os J., Kenis G., Rutten B.P., Environment and schizophrenia, Nature 2010; Nov 11; 468(7321):203–12.
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Momčilović, B., Prejac, J., Brundić, S. et al. An essay on human and elements, multielement profiles, and depression. Translat.Neurosci. 1, 322–334 (2010). https://doi.org/10.2478/v10134-010-0039-2
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DOI: https://doi.org/10.2478/v10134-010-0039-2