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Microwave-assisted synthesis and antibacterial activity of derivatives of 3-[1-(4-fluorobenzyl)-1H-indol-3-yl]-5-(4-fluorobenzylthio)-4H-1,2,4-triazol-4-amine

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Abstract

Herein, an excellent method for the synthesis of twelve novel Schiff base derivatives containing indole and triazole assisted by microwave irradiation is reported. Compared with the conventional method, the yields increased from 59–84 % to 85–96 % and the reaction time was reduced from 24–30 h to 4–8 min. Moreover, all series of the newly synthesized Schiff bases were evaluated for their antibacterial activity. The values of minimum inhibitory concentration (MIC) and IC50 indicated that many target compounds possessed excellent antibacterial activity against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Bacillus subtilis.

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Authors and Affiliations

  1. College of Chemistry and Environmental Protection Engineering, Southwest University for Nationalities, 610041, Chengdu, China

    Yong-Le Peng, Xing-Li Liu, Xiao-Hong Wang & Zhi-Gang Zhao

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  1. Yong-Le Peng
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  2. Xing-Li Liu
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  3. Xiao-Hong Wang
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  4. Zhi-Gang Zhao
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Correspondence to Zhi-Gang Zhao.

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Peng, YL., Liu, XL., Wang, XH. et al. Microwave-assisted synthesis and antibacterial activity of derivatives of 3-[1-(4-fluorobenzyl)-1H-indol-3-yl]-5-(4-fluorobenzylthio)-4H-1,2,4-triazol-4-amine. Chem. Pap. 68, 401–408 (2014). https://doi.org/10.2478/s11696-013-0461-2

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