Abstract
Many women suffer from new or worsening anxiety during pregnancy. In this pilot study, we investigated the effect of timing and severity of prenatal state anxiety symptoms on reduced birth weight. We hypothesized that: (1) Women with state anxiety symptoms during mid-gestation would deliver newborns with lower birth weight in comparison to participants with symptoms in early gestation and (2) compared to women with lower anxiety symptoms (< 50th percentile), women with medium-to-high state anxiety symptoms (> 50th percentile) would have lower birth weight offspring. The sample consisted of the first 30 pregnant women who agreed to participate in this pilot study. We assessed anxiety symptoms, using the State-Trait Anxiety Inventory during early and mid-gestation. We obtained birth weight from clinical charts. A hierarchical multiple regression showed that, after controlling for covariates, state anxiety symptoms in mid-gestation were associated with lower infant birth weight [F(9, 7) = 20.30, p<.001]. However, birth weight did not differ as a function of the severity of maternal state anxiety [F(1, 23)=.14, p=.71 and F(1, 24)=1.76, p=.20., respectively]. Clearly, our pilot data need replication. Once statistical significance is established with larger samples, it will be informative to examine the clinical significance of those findings.
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References
Catov J.M., Abatemarco D.J., Markovic N., Roberts J.M. Anxiety and optimism associated with gestational age at birth and fetal growth. Matern. Child Health J., 2010, 14, 758–764
Levin J.S., DeFrank R.S. Maternal stress and pregnancy outcomes: a review of the psychosocial literature. J. Psychosom. Obstetr. Gynaecol., 1988, 9, 3–16
Ross L.E., McLean L.M. Anxiety disorders during pregnancy and the postpartum period: a systematic review. J. Clin. Psychiatry, 2006; 67(8): 1285–1298
Vythilingum B. Anxiety disorders in pregnancy. Curr Psychiatry Rep 2008 Aug; 10(4):331–335
Hosseini S.M., Biglan M.W., Larkby C., Brooks M.M., Gorin M.B., Day N.L. Trait anxiety in pregnant women predicts offspring birth outcomes. Paediatr. Perinat. Epidemiol., 2009, 23, 557–766
Philips D.I.W. Insulin resistance as a programmed response to fetal undernutrition. Diabetol. 1996; 39: 1119–1122
Philips DIW. Birth weight and the future development of diabetes. A review of the evidence. Diab. Care, 1998, 21(2), B150–155
Hocher B. Fetal programming of cardiovascular diseases in later life - mechanisms beyon maternal undernutrition. J. Physiol., 2007, 287–288
Vardavas C.I., Chatzi L., Patelarou E., Plana E., Sarri K., Kafatos A. et al. Smoking and smoking cessation during early pregnancy and its effect on adverse pregnancy outcomes and fetal growth. European Journal of Pediatrics, 2010, 169, 741–748
Keegan J., Parva M., Finnegan M., Gerson A., Belden, M. Addiction in pregnancy. Journal of Addictive Diseases, 2010, 29, 175–191
Raatikainen K., Huurinainen P., Heinonen S. Smoking in early gestation or through pregnancy: a decision crucial to pregnancy outcome. Prev. Med., 2007, 44, 59–63
Visscher W.A., Feder M., Burns A.M., Brady T.M., Bray R.M. The impact of smoking and other substance use by urban women on the birthweight of their infants. Sub. Use Misuse, 2003, 38(8), 1063–1093
Nasreen H.E., Kabir Z.N., Forsell Y., Edhborg, M. Low birth weight in offspring of women with depressive and anxiety symptoms during pregnancy: results from a population based study in Bangladesh. BMC Public Health, 2010, 10 (515
Sen J., Roy A., Mondal N. Association of maternal nutritional status, body composition and socioeconomic variables with low birth weight in India. J. Trop. Pediatr., 2010, 56(4), 254–259
Nepomnyaschy L. Socioeconomic gradients in infant health across race and ethnicity. Matern. Child Health J., 2009, 13, 720–731
Najati N., Gojazadeh M. Maternal and neonatal complications in mothers under 18 years. Patient Preference and Adherence, 2010, 4, 219–222
Spielberger C.D., Gorsuch R.L., Lushene R.E. Manual for the State-Trait Anxiet Inventory, 1970, Palo Alto, CA: Consulting Psychologists Press
Gauthier J, Bouchard S. Adaptation canadiennefrançaise de la forme révisée du “State-Trait Anxiety Inventory” de Spielberger [French- Canadian adaptation of the revised “State-Trait Anxiety Inventory”]. Can. J. Behav. Science, 1993, 25, 559–578
Tilton S.R. Review of the state-trait anxiety inventory (STAI). News Notes, 2008, 48(2)
Huang F.Y., Chung H., Kronke K., Delucci K., Spitzer R., Using the Patient Health Questionnaire-9 to Measure Depression among Racially and Ethnically Diverse Primary Care Patients. J. Gen. Intern. Med., 2006, 21(6), 547–552
Cohen S., Kamarck T., Mermelstein R. A global measure of perceived stress. Journal of Health and Social Behavior, 2003, 24, 385–396
Sewitch M.J., Dobkin P.L., Bernatisky S., Baron M., Starr M., Cohen M., & Fitzcharles, A. Medication non-adherence in women with fibromyalgia. Rheumatol., 2004, 43, 648–654
Azar R., Paquette D., Zoccolillo M., Baltzer F., Tremblay R.E. The association of major depression, and maternal overcontrol with a failure to show a cortisol buggered response in 4 month-old-infants of teenage mothers. Biol. Psychiatr., 2007, 62, 573–579
Philips D.I.W., Jones A. (2006). Fetal programming of autonomic and HPA function: do people who were small babies have enhanced stress responses? J. Physiol., 572, 45–50
Field T., Diego M., Hernandez-Reif M., Schanberg S., Kuhn C., Yando R. et al. Pregnancy anxiety and comorbid depression and anger: effects on the fetus and neonate. Depr. Anxiety, 2003, 17, 140–151
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Azar, R., Singer, S. Maternal prenatal state anxiety symptoms and birth weight: A pilot study. cent.eur.j.med 7, 747–752 (2012). https://doi.org/10.2478/s11536-012-0078-9
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DOI: https://doi.org/10.2478/s11536-012-0078-9