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Synthesis, characterization and controlled toxicity of a novel hybrid material based on cisplatin and docetaxel

  • Research Article
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Central European Journal of Chemistry

Abstract

This paper is focused on the synthesis and characterization of a novel hybrid material based on cisplatin and docetaxel-loaded functionalized simultanously carbon nanotubes able to be used in cancer therapy as drug delivery system with controlled toxicity. This material was physico-chemically investigated by determining the structure, as evidenced by Fourier transform infrared (FTIR) spectroscopy, transmission electronmicroscopy (TEM) and its stability was studied with the aid of thermogravimetric analysis (TGA). The amount of platinum ions released into the solution of simulated body fluid (SBF) was highlighted by coupled plasma mass spectrometry (ICP-MS). Toxicology experiments were performed with MDA-MB 231 breast cancer epithelial cells. The performance of the new drug delivery hybrid material was compared with functionalised carbon nanotubes with therapeutic agents functionalized with a single therapeutic agent.

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Author information

Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, University of Bucharest, Bucharest, 050095, Romania

    Mihaela Radu & Anca Dinischiotu

  2. Department of General Chemistry, Polytechnic University of Bucharest, Bucharest, 011061, Romania

    Mariana Prodana, Adriana Voiculet & Ioana Demetrescu

  3. Department of Polymer Science and Technology, Polytechnic University of Bucharest, Bucharest, 010072, Romania

    Sorina Garea & Horia Iovu

Authors
  1. Mariana Prodana
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  2. Adriana Voiculet
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  3. Sorina Garea
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  4. Mihaela Radu
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  5. Horia Iovu
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  6. Ioana Demetrescu
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  7. Anca Dinischiotu
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Correspondence to Anca Dinischiotu.

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Prodana, M., Voiculet, A., Garea, S. et al. Synthesis, characterization and controlled toxicity of a novel hybrid material based on cisplatin and docetaxel. cent.eur.j.chem. 12, 1008–1015 (2014). https://doi.org/10.2478/s11532-014-0536-0

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  • DOI: https://doi.org/10.2478/s11532-014-0536-0

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