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Validation of videodensitometric myocardial perfusion assessment

Research Article

  • Research Article
  • Published:
Central European Journal of Medicine

Abstract

Introduction

Invasive methods for assessment of coronary microcirculatory function are time- and instrumentation-consuming tools. Recently, novel computer-assisted videodensitometric methods have been demonstrated to provide quantitative information on myocardial (re)perfusion. The aim of the present prospective study was to evaluate the accuracy of videodensitometry-derived perfusion parameters in patients with stable angina undergoing elective coronary angiography.

Methods

The study comprised 13 patients with borderline epicardial coronary artery stenosis (40–70%). Coronary flow reserve and index of microcirculatory resistance were measured by using an intracoronary pressure and temperature sensor-tipped guidewire. A videodensitometric quantitative parameter of myocardial perfusion was calculated by the ratio of maximal density (Gmax) and the time to reach maximum density (Tmax) of the time-density curves in regions of interest on conventional coronary angiograms. Myocardium perfusion reserve was calculated as a ratio of hyperemic and baseline Gmax/Tmax.

Results

At hyperemia a significant increase in Gmax/Tmax could be observed (p <0.0001). Significant correlations were found between myocardium perfusion reserve and coronary flow reserve (r =0.82, p =0.0008) and between hyperemic Gmax/Tmax and hyperemic index of microcirculatory resistance (r =−0.72, p =0.0058).

Conclusions

Videodensitometric Gmax/Tmax assessment seems to be a promising method to assess the myocardial microcirculatory state.

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Authors and Affiliations

  1. Division of Invasive Cardiology, Department of Cardiology, Medical Faculty, Albert-Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary

    Ferenc T. Nagy, Attila Nemes, Tamás Szűcsborus, András Katona, Viktor Sasi, Zsolt Zimmermann, Anita Kalapos, Tamás Forster & Imre Ungi

  2. School of Computing, Queen’s University, Kingston, ON, Canada

    Tamás Ungi

Authors
  1. Ferenc T. Nagy
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  2. Attila Nemes
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  3. Tamás Szűcsborus
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  4. Tamás Ungi
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  5. András Katona
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  6. Viktor Sasi
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  7. Zsolt Zimmermann
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  8. Anita Kalapos
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  9. Tamás Forster
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  10. Imre Ungi
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Correspondence to Attila Nemes.

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Nagy, F.T., Nemes, A., Szűcsborus, T. et al. Validation of videodensitometric myocardial perfusion assessment. cent.eur.j.med 8, 600–607 (2013). https://doi.org/10.2478/s11536-013-0168-3

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  • DOI: https://doi.org/10.2478/s11536-013-0168-3

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