Drugs & Aging

, Volume 26, Issue 9, pp 769–779

NSAID Use and the Risk of Parkinson’s Disease

Systematic Review and Meta-Analysis of Observational Studies
  • Ali Samii
  • Mahyar Etminan
  • Matthew O. Wiens
  • Siavash Jafari
Original Research Article

DOI: 10.2165/11316780-000000000-00000

Cite this article as:
Samii, A., Etminan, M., Wiens, M.O. et al. Drugs Aging (2009) 26: 769. doi:10.2165/11316780-000000000-00000



Several studies have suggested that NSAID use may modify the risk of developing Parkinson’s disease (PD).


Our aim was to conduct a meta-analysis of observational studies evaluating NSAID use and the risk of PD.


We systematically searched MEDLINE (1966–November 2008), EMBASE (1980–November 2008) and other databases. Data from 11 studies were included in the meta-analysis. We used the random effects model to calculate risk ratios (relative risks) and their corresponding 95% confidence intervals (CIs).


The pooled risk ratio of PD with NSAID use was 0.95 (95% CI 0.80, 1.12). The pooled risk ratio of PD with high-dose or long-duration NSAID use was 0.91 (95% CI 0.78, 1.05). The pooled risk ratio of PD for aspirin (acetylsalicylic acid) users was 1.08 (95% CI 0.93, 1.26). The pooled risk ratio of PD among ibuprofen users was 0.76 (95% CI 0.65, 0.89). The pooled risk ratio of PD in men using NSAIDs was 0.79 (95% CI 0.69, 0.92), and in women using NSAIDs, it was 0.72 (95% CI 0.45, 1.15).


NSAIDs as a class do not seem to modify the risk of PD. However, ibuprofen may have a slight protective effect in lowering the risk of PD. Although the risk ratios of PD in male and female NSAID users were similar, the 95% CI for men was suggestive of a slight risk reduction.

Copyright information

© Adis Data Information BV 2009

Authors and Affiliations

  • Ali Samii
    • 1
  • Mahyar Etminan
    • 2
  • Matthew O. Wiens
    • 3
    • 4
  • Siavash Jafari
    • 5
  1. 1.Department of NeurologyUniversity of Washington, and the Seattle VA Parkinson Disease Research Education and Clinical CenterSeattleUSA
  2. 2.Centre for Clinical Epidemiology and Evaluation, Department of Medicine, Faculty of MedicineUniversity of British ColumbiaVancouverCanada
  3. 3.Faculty of Pharmaceutical SciencesUniversity of British ColumbiaVancouverCanada
  4. 4.Chilliwack General HospitalChilliwackCanada
  5. 5.School of Population and Public HealthUniversity of British ColumbiaVancouverCanada
  6. 6.Seattle Veterans Administration Medical CenterUniversity of Washington School of MedicineSeattleUSA