Original Research Article

Drugs & Aging

, Volume 26, Issue 9, pp 769-779

First online:

NSAID Use and the Risk of Parkinson’s Disease

Systematic Review and Meta-Analysis of Observational Studies
  • Ali SamiiAffiliated withDepartment of Neurology, University of Washington, and the Seattle VA Parkinson Disease Research Education and Clinical Center Email author 
  • , Mahyar EtminanAffiliated withCentre for Clinical Epidemiology and Evaluation, Department of Medicine, Faculty of Medicine, University of British Columbia
  • , Matthew O. WiensAffiliated withFaculty of Pharmaceutical Sciences, University of British ColumbiaChilliwack General Hospital
  • , Siavash JafariAffiliated withSchool of Population and Public Health, University of British Columbia

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Several studies have suggested that NSAID use may modify the risk of developing Parkinson’s disease (PD).


Our aim was to conduct a meta-analysis of observational studies evaluating NSAID use and the risk of PD.


We systematically searched MEDLINE (1966–November 2008), EMBASE (1980–November 2008) and other databases. Data from 11 studies were included in the meta-analysis. We used the random effects model to calculate risk ratios (relative risks) and their corresponding 95% confidence intervals (CIs).


The pooled risk ratio of PD with NSAID use was 0.95 (95% CI 0.80, 1.12). The pooled risk ratio of PD with high-dose or long-duration NSAID use was 0.91 (95% CI 0.78, 1.05). The pooled risk ratio of PD for aspirin (acetylsalicylic acid) users was 1.08 (95% CI 0.93, 1.26). The pooled risk ratio of PD among ibuprofen users was 0.76 (95% CI 0.65, 0.89). The pooled risk ratio of PD in men using NSAIDs was 0.79 (95% CI 0.69, 0.92), and in women using NSAIDs, it was 0.72 (95% CI 0.45, 1.15).


NSAIDs as a class do not seem to modify the risk of PD. However, ibuprofen may have a slight protective effect in lowering the risk of PD. Although the risk ratios of PD in male and female NSAID users were similar, the 95% CI for men was suggestive of a slight risk reduction.