Summary
Moderate or severe depression is now one of the most common diseases of our time with a prevalence of nearly 3 %. It seems likely that this prevalence has increased as a result of the wider use of drugs which have an effect on the neurotransmitters. Changes in the levels of these neurotransmitters in the central nervous system are thought to he the biochemical basis for the development of at least some depressive illnesses.
Drug-induced depressions are more likely to occur in those individuals who are genetically predisposed to depression or who have had a previous depressive illness. Other groups who are particularly susceptible to these effects are the elderly.
Many groups of drugs have a primary or secondary action on the central nervous system neurotransmitter function. Some 200 drugs have been claimed to cause depression in certain patients, but only a relatively small number precipitate depressive symptoms with any frequency. Those most commonly implicated are the long-acting antipsychotics, barbiturates, ethanol, oral contraceptives and antihypertensive agents. It is important to remember that some drugs, such as reserpine, cause depression as a side-effect during their therapeutic use whereas others, such as fenfluramine, cause depression mainly when they are withdrawn too rapidly.
In those patients presenting with depression, it is important to review the current drug therapy in order to assess the part played by these drugs in the development of the depression. Following this assessment, drug therapy should be adjusted appropriately. However, a distinction must be made between the symptoms of depression, those physiological changes which occur during treatment with a variety of drugs, and the patient’s reaction to the disease for which they are being treated.
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References
Abrahams, M.J.; Armstrong, J. and Whitlock, F.A.: Drugs dependence in Brisbane. Medical Journal of Australia 2: 397 (1970).
Achte, K.A.: Somatic Symptoms in Depression; Kielholz (Ed) in Depression in Everyday Practice (Huber, Bern 1974).
de Alarcon, R. and Carney, M.W.P.: Severe depressive mood changes following slow release intramuscular fluphenazine injections. British Medical Journal 3: 564 (1969).
American Medical Association Council on Drugs. Evaluation of an antidiarrhoeal agent. Journal of the American Medical Association 187: 52 (1964).
American Medical Association Council on Drugs. Evaluation of a new antipsychotic agent: Haloperidol. Journal of the American Medical Association 205: 105 (1968).
Ayd, F.J.: This depot fluphenazines: a Reappraisal after ten years clinical experience. American Journal of Psychiatry 132: 491 (1975).
Bant, W.: Antihypertensive drugs and depression. Proceedings of the Royal Society of Medicine 67: 919 (1974).
Bauer, G.E.; Croll, F.J.T.; Goldrick, R.B.; Jeremy, D.; Baftos, J.; Whyte, H.M. and Young, A.A.: Guanethidine in the treatment of hypertension. British Medical Journal 2: 410 (1960).
Bianco, P.; del Anselmi, B. and Michelacci, S.: The effect of indomethacin on pain, fever and vasomotor activity; in Recent Additions to the Non-Steroid Antirheumatic Therapy (Minerva Medica, Milan 1965).
Blechman, W.J.; Schmid, F.R., April, P.A.; Wilson, C.H. and Brooks, C.P.: Ibuprofen or aspirin in rheumatoid arthritis therapy. Journal of the American Medical Association 233–236: (1975).
Briggs, M.H. and Briggs, M.: Hormonal influences on erythrocyte catecol-o-methyl transferase activity in humans. Experientia 29: 278 (1973).
Brogden, R.N.; Pinder, R.M., Sawyer, P.R.: Speight, T.M. and Avery, G.S.: Low dose clonidine: A review of its therapeutic efficacy in migraine prophylaxis. Drugs 10: 357 (1975).
Brogden, R.N.; Speight, T.M. and Avery, G.S.: Levodopa: A review of its pharmacological properties and therapeutic uses with particular reference to parkinsonism. Drugs 2: 262 (1971).
Brogden, R.N.; Speight, T.M. and Avery, G.S.: Pentazocine: A review. Drugs 5: 6 (1973).
Bucci, L.: Drug-induced depression and tryptophan metabolism. Diseases of the Nervous System 33: 105 (1972).
Buchanan, D.: in Moser (Ed) Diseases of Medical Progress, 3rd ed (Thomas, Springfield 111. 1969).
Bulpitt, C.J. and Dollery, C.T.: Side effects of hypotensive agents evaluated by a self-administered questionnaire. British Medical Journal 3: 485 (1973).
Caldwell, J. and Sever, P.S.: Biochemical pharmacology of abused drugs II: Alcohol and barbiturates. Clinical Pharmacology and Therapeutics 16: 737 (1974).
Carney, M.W.P. and Sheffíeld, B.F.: 42 Months of experience of fluphenthixol decanoate in the maintenance treatment of schizophrenics. Current Medical Research and Opinion 3: 447 (1975).
Carney, M.W.P. and Sheffield, B.F.: Comparison of antipsychotic depot injections in the maintenance treatment of schizophrenia. British Journal of Psychiatry 129: 476 (1976).
Carroll, J.D. and Maclay, W.P.: Pizotifen in migraine prophylaxis. Current Medical Research and Opinion 3: 68 (1975).
Chadwick, D.; Jenner, P. and Reynolds, E.H.: Regulatory activity of lithium on manic-depressive illness. Lancet 1: 473 (1975).
Christian, S.T.: in Mule and Brill (Ed) Chemical and Biological Aspects of Drug Dependence p.449 (C.R.C. Press, Cleveland 1972).
Church, G. and Schamroth, L.; Schwartz, N.L. and Marriott, H.J.L.: Deliberate digitalis intoxication. Annals of Internal Medicine 57: 946 (1962).
Clark, F.: Drugs and vitamin deficiency. Adverse Drug Reaction Bulletin No. 57: 196 (1976).
Clayden, J.R.; Bell, J.W. and Pollard, P.: Menopausal flushing: double-blind trial of a non-hormonal preparation. British Medical Journal 1: 409 (1974).
Clineschmidt, D.V.; Totaro, J.A.; McGuffin, J.C. and Pflueger, A.B.: Fenfluramine: long-term reduction in brain serotonin (5HT). European Journal of Pharmacology 35: 211 (1976).
Cochrane, G.M.: A double-blind comparison of naproxen with indomethacin in osteoarthritis. Scandinavian Journal of Rheumatology 2 (Suppl:) 89 (1973).
Cohen, S.; Leonard, C.B.; Farberow, N.L. and Shneidman, E.S.: Tranquillisers and suicide in schizophrenic patients. Archives of General Psychiatry 11: 312 (1964).
Connell, P.H.: in Dukes (Ed) Mylers Side Effects of Drugs, vol. 8 (Excerpta Medica, Amsterdam 1975).
Consolo, S.; Grattini, S. and Ladinsky, H.: Action of benzodiazepines on the cholinergic system. Advances in biochemical psychopharmacology 14: 63 (1975).
Corbett, L.: Technique of fluphenazine decanoate therapy in acute schizophrenic illness. Diseases of the Nervous System 35: 35 (1974).
Curzon, G. and Greene, A.R.: Effect of hydrocortisone on rat brain 5-hydroxy-tryptamine. Life Sciences 7: 657 (1968).
Davis, V.E. and Walsh, M.J.: Effect of ethanol on neuroamine metabolism; in Israel and Mardones (Eds) Biological Basis of Alcoholism (Wiley, New York 1971).
De Nosaquo: The hallucinatory effect of pentazocine. Journal of the American Medical Association 210: 502 (1969).
Dewhurst, W.G.: On the chemical basis of mood. Journal of Psychosomatic Research 9: 115 (1965).
Dewhurst, W.G.: New theory of cerebral amine function and its clinical applications. Nature 218: 1130 (1968).
Dollery, C.T.; Emslie-Smith, D.; Mione, M.D.: Clinical and pharmacological studies with guanethidine in the treatment of hypertension. Lancet 2: 381 (1960).
Duhault, J.; Malen, C and Bonlanger, M.: Fenfluramine and 5-hydroxytryptophan: Is fenfluramine or nor-fenfluramine involved in the decrease of brain 5HT. Arzneimittel-Forschung 25: 1755 (1975).
Dunlop, D.: Abuse of drugs by the public and by doctors. British Medical Bulletin 26: 236 (1970).
Dykes, M.H.M.: Evaluation of three anorexiants. Journal of the American Medical Association 230: 270 (1974).
Eade, N.R. and Lasagna, L.: A comparison of acetophenacetin and acetaminophen II. Subjective effect in healthy volunteers. Journal of Pharmacology and Experimental Therapeutics 155: 301 (1967).
Editorial: Levodopa and Hypertension. British Medical Journal 1: 119 (1966).
Editorial: Oral contraception and depression. British Medical Journal 4: 380 (1969).
El-Yousef, M.K.; Janowsky, D.S.; Davis, J.M. and Rosenblatt, J.E.: Induction of severe depression by physositigmine in marihuana-intoxicated individuals. British Journal of Addiction 68: 321 (1973).
Feldstein, A.: Effect of ethanol on neurohumoral amine metabolism; in Kissin and Begleiter (Eds) Biology of Alcoholism, vol. 1, p.127 (Plenum Press, New York 1971).
Feldstein, A.: Ethanol-induced sleep in relation to serotonin turnover. Annals of the New York Academy of Sciences 215: 71 (1973).
Fuxe, A.; Hoekfelt, T. and Ungerstedt, U.: Central monoaminergic tracts; in Clark and Guidici (Eds) Principles of Psychopharmacology (Academic Press, New York 1970).
Gaind, R.: Fenfluramine (Ponderax) in the treatment of obese psychiatric patients. Brit. J. Psychiatry 115: 963 (1969).
Geller, I.; Purdy, R.; Merritt, J.N.: Alteration in the ethanol preference in the rat: the role of biogenic amines. Annals of New York Academy of Sciences 215: 54 (1973).
Giannini, A.J.: Side effects of metronidazole. American Journal of Psychiatry 134: 329 (1977).
Glatt, M.N.: A guide to addiction and its treatment. (Medical and Technical Publishing Company, Lancaster 1974).
Goldberg, H.C. and Marsden, C.A.: Catechol-o-methyl transferase: Pharmacological aspects and physiological role. Pharmacological Review 27: 135 (1975).
Goldman, A.L. and Braman, S.S.: Isoniazide: a review with emphasis on adverse effects. Chest 62: 71 (1972).
Goodman, L.S. and Gilman, A.: The pharmacological basis of therapeutics, 5th ed. (Macmillan, New York 1975).
Goodwin, F.K.: Psychiatric side effects of levodopa in man. Journal of American Medical Association 218: 1915 (1971).
Goodwin, F.K. and Bunney, W.E.: Depression following reserpine: a re-evaluation. Seminars in Psychiatry 3: 435 (1971).
Grant, E.C.G. and Pryce Davis, J.: Effect of oral contraceptives on depressive mood changes and on endometrial monoamine-oxidases and phosphatases. British Medical Journal 3: 777 (1968).
Greenblatt, D.J. and Shader R.I.: Benzodiazepines in clinical practice (Raven Press, New York 1974).
Gunn, E.L.M. and Lewander, T.: in Wikler (Ed) The addictive states, p.106 (Williams and Wilkins, Baltimore 1968).
Hall, C.W. and Joffe, J.R.: Aberrant response to diazepam — a new syndrome. American Journal of Psychiatry 129: 738 (1972).
Harding, T.: Depression following fenfluramine withdrawal. British Journal of Psychiatry 121: 338 (1972).
Harris, L.S. and Dewey, W.L: Role of cholinergic systems in the central action of narcotic agonists and antagonists; in Kosterlitz, Collier and Villareal (Eds) Agonist and Antagonist Actions of Narcotic Analgesic Drugs (Macmillan, London 1972).
Haskovic, L. and Soncek, K.: The action of methysergide in manic states. Psychopharmacologia 15: 415 (1969).
Helmy, B. Side effects of cycloserine. Scandinavian Journal of Respiratory Disease. 71 (Suppl): (1970).
Herzberg, B.N.; Draper, K.C.; Johnson, A.L. and Nicol, G.C.: Oral contraceptives, depression and libido. British Medical Journal 3: 495 (1971).
Hippius, H.: Comments on conduct of antidepressive treatment in everyday practice; in Kielholz (Ed) Depression in Everyday Practice (Huber, Bern 1974).
Hunter, R.; Barnes, J. and Mathews,: Effect of folic acid supplement on serum vitamin B12 levels in patients on anticonvulsants. Lancet 2: 666 (1969).
Hurwitz, N.: Predisposing factors in adverse drug reactions. British Medical Journal 1: 536 (1969).
Hussar, A.E.: Effect of tranquilisers on morbidity and mortality in a mental hospital. Journal of the American Medical Association 179: 682 (1962).
Imlah, N.W.: Unusual effect of fenfluramine. British Medical Journal 2: 178 (1970).
Islam, N.A. and Sreedharan, T.J.: Convulsions, hypoglycaemia and glycosuria from overdose of nalidixic acid. Journal of the American Medical Association 192: 1100 (1965).
Israel, Y. and Mardones, J.: Biological basis of alcoholism (Wiley, New York 1971).
Janowsky, D.S.; El-Yousef, K.; Davis, M. and Sekerke, H.J.: A cholinergic-adrenergic hypothesis of mania and depression. Lancet 2: 632 (1972).
Jenkins, R.B. and Groh, R.H.: Mental symptoms in Parkinson patients treated with l-dopa. Lancet 2: 177 (1970).
Johnson, D.A.W.: The side-effects of fluphenazine decanoate. British Journal of Psychiatry 123: 519 (1973).
Johnson, P.; Kitchin, A.H.; Lawther, C.P. and Turner, R.W.: Treatment of hypertension with methyldopa. British Medical Journal 1: 133 (1966).
Johnson, G. and Regardh, C-G.: Clinical pharmacokinetics of β-adrenoceptor blocking drugs. Clinical Pharmacokinetics 1: 233 (1976).
Kane, F.J.: Carbondisulfide intoxication from overdose of disulfuram. American Journal of Psychiatry 127: 690 (1970).
Kellert, R.J. and Hamilton, M.: The treatment of benign hypertension with clonidine. Scottish Medical Journal 15: 137 (1970).
Kitson, T.M.: The disulfuram-ethanol reaction: A Review. Quarterly Journal of Studies of Alcohol 38: 96 (1977).
Kutner, S.J. and Brown, W.L.: Depression and contraception. Journal of Nervous and Mental Disease 155: 153 (1972).
Leeton, J.: Depression induced by oral contraception and the role of vitamin B6 in its management. Australian and New Zealand Journal of Psychiatry 8: 85 (1974).
Lehmann, H.E.; Ananth, J.V. and Geagea, K.C.: Treatment of depression with dexedrine and demerol. Current Therapeutic Research 13: 42 (1971).
Leston, J.M.; Rey, J.C.; Gonzalez-Montaner, L.J.; Grondona, A.; Zavalla, P.N.: Psychosomatic reactions to cycloserine in the treatment of tuberculosis. Scandinavian Journal of Respiratory Disease 71 (Suppl): (1970)
Levin, A.: The non-medical misuse of fenfluramine by drug-dependent South Africans. Postgraduate Medical Journal 1 (Suppl): 183 (1975).
Lewis, A. and Hoghuli, M.: An evaluation of depression as a side effect of oral contraceptives. British Journal of Psychiatry 115: 697 (1969).
Liddon, S.C. and Satran, R.: Disulfuram (antabuse) psychosis. American Journal of Psychiatry 123: 1284 (1967).
Louria, D.V.: in Zarafonetis (Ed) Proceedings of international conference on drug abuse (Lea and Febiger, Philadelphia 1972).
McClelland, H.A.: Psychiatric complications of drug therapy. Adverse Drug Reactions Bulletin 40: 128 (1973).
Mackay, I.R.: Chronic hepatitis: Effect of prolonged suppressive treatment and comparison of azathioprine with prednisolone. Quarterly Journal of Medicine 37: 379 (1968).
Madsen, J.A.: A study of urinary 5HIAA excretion. Advances in Biochemical Psychopharmacology 11: 249 (1974).
Magnent, E.W.: in Wikler (Ed) The addictive states, p.89 (Williams and Wilkins, Baltimore 1968).
Mendels, J. and Frazer, A.: Brain biogenic amine depletion and mood. Archives of General Psychiatry 30: 447 (1974).
Meyler, L.: in Dukes (Ed) vol. 8 Meyler’s side effects of drugs, (Excerpta Medica, Amsterdam 1976).
Meyler, L. and Herxheimer, A.: Side Effects of Drugs, vol. 7 (Excerpta Medica, Amsterdam 1972).
Murer, E.H.; Davenport, K. and Day, R.J.: Platelet secretion induced by calcium iontophoresis: Effect of anti-inflammative drugs. Thrombosis et Diathesis Haemorrhagica (Stuttgart) 34: 554 (1975).
Newton, R.W.: Side effects of drugs used to treat tuberculosis. Scottish Medical Journal 20: 47 (1975).
Ng, J.; Phelan, E.L.; McGregor, T.D.; Laverty, R.; Taylor, A.M. and Smirk, H.: Properties of catapres, a new hypotensive drug: a preliminary report. New Zealand Medical Journal 66: 684 (1967).
Nies, A.S.: Adverse reactions and interactions limiting the use of antihypertensive drugs. American Journal of Medicine 58: 495 (1975).
Nilsson, L. and Soelvell,: Clinical studies on oral contraception: A randomised double-blind crossover study of four different preparations. Acta Obstetrica et Gynaecologica Scandinavica 46 (Suppl): 8 (1967).
North R.: Cardiovascular disease; in Moser (Ed) Diseases of Medical Progress, 3rd ed. (Thomas, Springfield I11. 1969).
Oates, J.A.; Seligmann, A.W.; Clark, N.A.; Rousseau, P. and Lee, R.E.: The relative efficiency of guanethidine, methyldopa and pargyline as antihypertensive agents. New England Journal of Medicine 273: 729 (1965).
O’Brien, W.M.: Indomethacin: a survey of clinical trials. Clinical Pharmacology and Therapeutics 9: 94 (1968).
O’Malley, K.; Judge, T.C. and Crooks, J.: Geriatric clinical pharmacology and therapeutics; in Avery (Ed) Drug Treatment, p.123 (ADIS Press, Sydney, PSG Acton Mass; Churchill Livingstone, Edinburgh 1976).
Oswald, I.: Fenfluramine and psychosis. British Medical Journal 4: 103 (1974).
Paton, W.D.M.: in Steinberg (Ed) Scientific basis of Drug Dependence (Churchill, London 1969).
Pariente, D.: Methyldopa and depression. British Medical Journal 3: 110 (1973).
Pasaigiklian, M. and Biondi, L.: Neurologic and behavioral reactions of tuberculosis patients treated with cycloserine. Scandinavian Journal of Respiratory Disease 21 (Suppl): (1970).
Petrie, J.C.; Galloway, D.D.; Jeffers, T.A. and Webster, J.: Adverse reactions to beta-blocking drugs: A Review. Postgraduate Medical Journal 52 (Suppl 4): 63 (1976).
Pinder, R.M.; Brogden, R.N.; Sawyer, Phyllis R.; Speight, T.M. and Avery, G.S.: Fenfluramine: A review of its pharmacological properties and therapeutic efficacy in obesity. Drugs 10: 241 (1975).
Prange, H.A.: The use of antidepressant drugs in elderly patients. Advances in Behavioural Biology 6: 225 (1973).
Prescott, L.F.: in Meyler and Herxheimer (Eds) vol. 7 (Excerpta Medica, Amsterdam 1972).
Prichard, B.N.C., Johnston, A.W.; Hill, I.D. and Rosenheim, L.: Bethanidine, guanethidine and methyldopa in treatment of hypertension: A within-patient comparison. British Medical Journal 1: 135 (1968).
Redhead, I.H.: Lomotil sensitivity. Lancet 1: 573 (1969).
Reynolds, E.H.; Preece J.M.; Bailey, J. and Coppen, A.: Folate deficiency and depressive illness. British Journal of Psychiatry 117: 287 (1970).
Robinson, D.S.; Davis, J.M.; Nies, A.; Ravaris, C.L. and Sylvester, P.: Monoamine oxidase activity in human brain plasma and platelets. Arch. Gen. Psych. 24: 536 (1971).
Robinson, D.S.; Nies, A.; Davis, J.N.; Bunney, W.E.; Davis, J.M.; Colburn, R.W.; Bourne, H.R.; Shaw, D.M. and Coppen, A.J.: Ageing monoamines and monoamine oxidase levels. Lancet 1: 290 (1972).
Robinson, D.S.: Changes in monoamine oxidases and monoamines in human development and ageing. Federation Proceedings 34: 103 (1972).
Robinson, R.G.: Indomethacin in rheumatic disease: A reassessment. Medical Journal of Australia 1: 971 (1966).
Robson, J.M. and Stacey, R.S.: Recent advances in pharmacology, 4th ed (Churchill, London 1968).
Ryan, H.F.; Marshall, F.H.; Scott, G.E.; Krebs, R. and Thompson, B.L.: Increase in suicidal thoughts and tendencies: Association with diazepam therapy. Journal of the American Medical Association 203: 1137 (1968).
Sainsbury, P.: Suicide in London (Chapman and Hall, London 1975).
Sanders-Bush, E.; Gallagher, D.A.; Sulser, F.: On the mechanism of brain 5HT depletion by p-chloroamphetamine and related drugs and the specificity of their actions. Advances in Biochemical Psychopharmacology 10: 185 (1974).
Sartorius, N.: in Kielholz (Ed) Depressive Illness as a World-Wide Problem (Huber, Bern 1974).
Schallek, W.; Schlosser, W.; Randall, L.O.: Recent developments in the pharmacology of the benzodiazepines. Advances in Pharmacology and Chemotherapy 10: 119 (1972).
Schwab, R.S.; Poskanzer, D.C, England, A.C.; Young, R.R.: Amantadine in Parkinson’s disease. Journal of the American Medical Association 122: 792 (1972).
Shader, R.I.: Psychiatric complications of medical drugs (Raven Press, New York 1972).
Shaw, D.M.; Camps, F.E.; Eccleston, E.C.: 5-HT in the hind brain of depressive suicides. British Journal of Psychiatry 113: 1407 (1967).
Silverstone, T.: Intermittent treatment with anorectic drugs. Practitioner 213: 245 (1974).
Simpson, F.O.: Hypertension and depression and their treatment. Australian and New Zealand Journal of Psychiatry 7: 133 (1973a).
Simpson, F.O.: Antihypertensive drug therapy. Drugs 6: 333 (1973b).
Simpson, F.O.: (Editor) Symposium on Hypertension. Drugs 11 (Suppl. 1): 1–204 (1976).
Simpson, F.O.: (Editor) Pfizer Forum on Prazosin and Hypertension. Medical Journal of Australia 2 (Special Suppl.): 23 August 20th (1977).
Simpson, F.O. and Waal-Manning, H.J.: Hypertension and depression. Journal of the Royal College of Physicians of London 6: 14 (1971).
Siomopoulos, V.: Amphetamine psychosis: Overview and an hypothesis. Diseases of the Nervous System 36: 336 (1975).
Smith, W.H.; Thurn, R.H. and Bromer, L.: Comparative evaluations of rauwolfia whole root and reserpine. Clinical Pharmacology and Therapeutics 10: 338 (1969).
Snaith, R.P. and McCourbie, M.: Antihypertensive drugs and depression. Psychological Medicine 4: 393 (1974).
Sullivan, J.L.; Segal, D.S.; Kuczenski, R.T. and Mandell, A.J.: Propranolol-induced rapid activation of rat striatal tyrosinehydroxylase concomitant with behavioural depression. Biological Psychiatry 4: 193 (1972).
Sourkes, T.L.: The action of methyldopa on the brain. British Medical Bulletin 21: 66 (1965).
Speira, H.: Excretion of tryptophane metabolites in rheumatoid arthritis. Arthritis and Rheumatism 9: 318 (1966).
Stafford, J.R. and Fann, W.E.: Drug interactions with guanidinium antihypertensives. Drugs 13: 57 (1977).
Steel, J.M. and Briggs, M.: Withdrawal depression in obese patients after fenfluramine treatment. British Medical Journal 3: 26 (1972).
Steel, J.M.; Munro, J.F.; Duncan, L.J.P.: A comparative trial of different regimens of fenfluramine and phentermine in obesity. Practitioner 211: 232 (1973).
Stein, I.; Wise, C.D. and Belluzzi, J.D.: Effect of benzodiazepines on central serotonergic mechanisms. Advances in Biochemical Psychopharmacology 14: 29 (1975).
Stimmel, B. and Kreek, M.J.: Pharmacologic Action of Heroin in Stimmel (Ed) Heroin Dependency (Stratton, New York 1975).
Tagliamonte, A.; Biggio, G.; Vargia, L.; Gessi, A.: Increase of brain tryptophane and stimulation of brain serotonin synthesis by salicylates. Journal of Neurochemistry 20: 909 (1973).
Takaishi, S.; Yamani, H.; Condo, H.: Cerebrospinal fluid monoamine metabolites in alcoholics. A comparative study with depression. Folia Psychiatrica Neurologica Japonica 28: 347 (1974).
Thompson, N. and Perry, J.S.: Further experience with in-domethacin in the treatment of rheumatic disorders. British Medical Journal 1: 80 (1966).
Ungeleider, J.T.; Fisher, E.D. and Fuller, M.: The dangers of LSD. Journal of the American Medical Association 197: 389 (1966).
Van Praag, H.M.: in Myler and Peck (Eds) Drug-induced Diseases, p.286 (Excerpta Medica, Amsterdam 1968).
Verbeist, L.; Pregnat, J.; Gosimans, J.; Gyselen, A.: Tolerance ethionamide and PAS in original treatment of tuberculous patients. Scandinavian Journal of Respiratory Disease 47: 225 (1966).
Virkkunen, M.: Suicide in schizophrenia and paranoid psychoses. Acta Psychiatrica Scandinavica 250 (Suppl): (1974).
Voth, A.J.: Possible association between metronidazole and depression. Canadian Medical Association Journal 100: 1012 (1969).
Waal, H.J.: Propranolol-induced depression. British Medical Journal 2: 50 (1967).
Waal-Manning, H.J.: Which beta-blocker? Drugs 12: 412 (1976).
Wallach, M.B. and Gershon, S.: Psychiatric sequelae to tuberculous therapy; in Shader (Ed) Psychiatric complications of medical drugs (Raven Press, New York 1972).
Warnes, H.: Suicide and schizophrenia. Diseases of the Nervous System 29 (Suppl): 535 (1968).
Way, E.L.; Iwamato, E.T.; Borghara, H.N.; Lok, M.H.: Adaptive cholinergic and dopaminergic responses in morphia dependence. Advances in Biochemical Psychopharmacology 13: 169 (1975).
Weissman, M.M.; Slobetz, F.; Prusoff, B.; Mezretz, M. and Howard, P.: Clinical depression among narcotic addicts maintained in the community. American Journal of Psychiatry 133: 1434 (1976).
Whitlock, F.A.: The syndrome of barbiturate dependence. Medical Journal of Australia 2: 391 (1970).
Whitlock, F.A. and Price, J.: Use of beta-adrenergic receptor blocking drugs in psychiatry. Drugs 8: 109 (1974).
Williams, H.L. and Salamy, A.: Alcohol and Sleep; in Kissin and Begleiter (Eds) Biology of Alcoholism vol 2 (Plenum Press, New York 1972).
Youdin, M.B.H.; Holzbauer, M. and Woods, H.F.: Physicochemical properties, development and regulation of central and peripheral monoamine oxidase activity. Advances in Biochemical Psychopharmacology 12: 11 (1974).
Zacharias, F.J.: Patient acceptability of propranolol and the occurrence of side-effects. Postgraduate Medical Journal 52 (Suppl. 4): 87 (1976).
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Whitlock, F.A., Evans, L.E.J. Drugs and Depression. Drugs 15, 53–71 (1978). https://doi.org/10.2165/00003495-197815010-00004
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DOI: https://doi.org/10.2165/00003495-197815010-00004