Skip to main content
Log in

KIT and BRAF Mutational Status in a Patient with a Synchronous Lentigo Maligna Melanoma and a Gastrointestinal Stromal Tumor

  • Case Letter
  • Published:
American Journal of Clinical Dermatology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

References

  1. Curtin JA, Busam K, Pinkel D, et al. Somatic activation of KIT in distinct subtypes of melanoma. J Clin Oncol 2006; 24 (26): 4340–6

    Article  PubMed  CAS  Google Scholar 

  2. Wyman K, Atkins MB, Prieto V, et al. Multicenter phase II trial of high-dose imatinib mesylate in metastatic melanoma: significant toxicity with no clinical efficacy. Cancer 2006; 106 (9): 2005–11

    Article  PubMed  CAS  Google Scholar 

  3. Jiang X, Zhou J, Yuen NK, et al. Imatinib targeting of KIT-mutant oncoprotein in melanoma. Clin Cancer Res 2008; 14 (23): 7726–32

    Article  PubMed  CAS  Google Scholar 

  4. Li FP, Fletcher JA, Heinrich MC, et al. Familial gastrointestinal stromal tumor syndrome: phenotypic and molecular features in a kindred. J Clin Oncol 2005; 23 (12): 2735–43

    Article  PubMed  CAS  Google Scholar 

  5. Beadling C, Jacobson-Dunlop E, Hodi FS, et al. KIT gene mutations and copy number in melanoma subtypes. Clin Cancer Res 2008; 14 (21): 6821–8

    Article  PubMed  CAS  Google Scholar 

  6. Torres-Cabala CA, Wang WL, Trent J, et al. Correlation between KIT expression and KIT mutation in melanoma: a study of 173 cases with emphasis on the acral-lentiginous/mucosal type. Mod Pathol 2009; 22 (11): 1446–56

    Article  PubMed  CAS  Google Scholar 

  7. Antonescu CR, Busam KJ, Francone TD, et al. L576P KIT mutation in anal melanomas correlates with KIT protein expression and is sensitive to specific kinase inhibition. Int J Cancer 2007; 121 (2): 257–64

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgments

RNM is supported by the Medical Research Council Clinical Training Fellowship, UK. CAH is supported by Cancer Research UK. The authors have no conflicts of interest to declare.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Rubeta N. Matin.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Matin, R.N., Gonzalez, D., Thompson, L. et al. KIT and BRAF Mutational Status in a Patient with a Synchronous Lentigo Maligna Melanoma and a Gastrointestinal Stromal Tumor. Am J Clin Dermatol 13, 64–65 (2012). https://doi.org/10.2165/11593910-000000000-00000

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2165/11593910-000000000-00000

Keywords

Navigation