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Ulcerative Colitis

History of a Successful Treatment

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Abstract

In this report we describe a case of a 19-year-old woman with a severe to fulminant steroid-resistant ulcerative colitis that was successfully treated with infliximab. Severe to fulminant ulcerative colitis is a potentially life-threatening condition and although the mortality rate has dropped dramatically over the past 40 years, this has not been the case with colectomy which has remained unchanged. Recently, infliximab has been shown to be effective as rescue therapy for steroid-refractory cases.

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References

  1. Jarnerot G, Rolny P, Sandberg-Gertzen H. Intensive intravenous treatment of ulcerative colitis. Gastroenterology 1983; 85: 351–7

    Google Scholar 

  2. Meyers S, Lerer PK, Feuer EJ, et al. Predicting the outcome of corticoid therapy for acute ulcerative colitis. Results of a prospective, randomized, double-blind clinical trial. J Clin Gastroenterol 1987; 9: 50–4

    Article  PubMed  CAS  Google Scholar 

  3. Lichtiger S, Present DH, Kornbluth A, et al. Cyclosporine in severe ulcerative colitis refractory to sterid therapy. N Engl J Med 1994; 30-330: 1841–5

    Article  Google Scholar 

  4. Carter MU, Lobo AJ, Travis SP. IBD Section, British Society of Gastroenterology. Guidelines for the management of inflammatory bowel disease in adults. Gut 2004; 53: V1–16

    Article  PubMed  Google Scholar 

  5. Jarnerot G, Rolny P, Sandberg-Gertzen H. Intensive intravenous treatment of ulcerative colitis. Gastroenterology 1985; 89: 1005–13

    PubMed  CAS  Google Scholar 

  6. McIntyre DB, Powell-Tuck J, Wood SR. Controlled trial of bowel rest in the treatment of severe active colitis. Gastroenterology 1980; 79: 1199–204

    Google Scholar 

  7. Rutgeerts P, Sanndborn WJ, Feagan BG, et al. Infliximab for induction and maintenance therapy for ulcerative colitis. N Engl J Med 2005; 8-353: 2462–76

    Article  Google Scholar 

  8. Sands BE, Tremaine WJ, Sandborn Wj, et al. Infliximab in the treatment of severe, steroid-refractory ulcerative colitis: a pilot study. Inflamm Bowel Dis 2001; 7: 83–7

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

Dr Lago received honoraria for the submission of the case report, which was funded by Schering-Plough/MSD Portugal.

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Correspondence to Paula Lago.

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Lago, P. Ulcerative Colitis. BioDrugs 24 (Suppl 1), 34–36 (2010). https://doi.org/10.2165/11586230-000000000-00000

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  • DOI: https://doi.org/10.2165/11586230-000000000-00000

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