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Taxanes in the Treatment of Non-Small Cell Lung Cancer

  • Review Article
  • Published:
Treatments in Respiratory Medicine

Abstract

Paclitaxel and docetaxel, drugs that bind tightly to β-tubulin and disrupt microtubule dynamics, are widely used in the treatment of non-small cell lung cancer (NSCLC), the most common cause of cancer death in men and women living in the US. These well tolerated drugs, alone or in combination with another cytotoxic agent, have been shown to increase the survival of patients with metastatic disease or malignant effusions. Both paclitaxel and docetaxel can be combined with concurrent chest irradiation for patients with locally advanced NSCLC. The combination of carboplatin and paclitaxel, when given postoperatively to patients with stage IB NSCLC, improved survival compared with surgery alone, with little toxicity. Taxane combinations are undergoing study as adjuvant therapy for patients with other stages of operable disease. Except for a recent trial with bevacizumab, efforts to improve the efficacy of taxane/platinum combinations in patients with advanced disease by adding a third ‘targeted’ drug have thus far been unsuccessful.

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  1. 1 The use of trade names is for product identification purposes only and does not imply endorsement.

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Acknowledgments

The authors receive financial support from the Emory University Winship Cancer Institute.

Dr Fanucchi has received research support from Bristol Meyers Squibb, Sanofi-Aventis, Novartis, Schering Plough, Millennium Pharmaceuticals. Dr Khuri has received research support from Sanofi-Aventis, Novartis, Schering Plough, Ligand Pharmaceuticals.

Additionally, Dr Khuri receives funding from the Department of Defense (DAMD 17-01-1-0689 Hong [PI], DAMD 17-02-1-0706 [Hong], DAMD W81XWH-04-1-0142 [Hong]), NIH/NCI (U01-CA21661-24, P50 CA97007-01 [Hong], P50 CA70907, DAMD [Hong], Eastern Cooperative Oncology Group Core Grant, NCI (1P20 CA103735-01), and the Georgia Cancer Coalition.

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  1. Winship Cancer Institute at Crawford Long Hospital, Emory University School of Medicine, 550 Peachtree Street - Glenn Building, Atlanta, Georgia, 30308, USA

    Michael Fanucchi & Fadlo R. Khuri

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Correspondence to Michael Fanucchi.

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Fanucchi, M., Khuri, F.R. Taxanes in the Treatment of Non-Small Cell Lung Cancer. Treat Respir Med 5, 181–191 (2006). https://doi.org/10.2165/00151829-200605030-00004

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