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Management of Ischemic Heart Disease in Patients with Chronic Kidney Disease

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Abstract

Patients with chronic kidney disease (CKD) and ischemic heart disease (IHD) have strikingly high mortality rates. In the general population, there has been a reduction in the mortality and morbidity rates for IHD through the implementation of effective risk-factor-reduction programs and better interventions for patients with established IHD. No such trend has been observed in patients with end-stage kidney disease.

This review article addresses the following topics: (i) epedemiology, pathogenesis, clinical CKD patients with IHD; (ii) diagnostic modalities for IHD and their limitation in CKD patients; (iii) medical treatment options and revascularization strategies for these high-risk patients; and (iv) optimal cardiovascular risk management. Generally, in CKD patients with IHD an aggressive approach to IHD is warranted, a low threshold for diagnostic testing should be employed, and awaiting a clinical trial targeting these patients they should be considered for all proven strategies to improve outcomes.

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  1. The use of trade names is for product identification purposes only and does not imply endorsement.

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Acknowledgments

Dr Reddan has received honoraria from Pfizer and Astra Zeneca for invited lectures. Drs Reddan and Glynn have received an honorarium from Roche for the development of guidelines for chronic kidney disease. No sources of funding were used in the preparation of this review.

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Authors and Affiliations

  1. Department of Medicine, Division of Nephrology, National University of Ireland, Galway, Ireland

    Arif Mutwali &  Donal Reddan

  2. Department of General Practice, National University of Ireland, Galway, Ireland

    Liam G. Glynn

  3. Unit 1, Merlin Park University Hospital, Galway, Ireland

    Donal Reddan

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  1. Arif Mutwali
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  2. Liam G. Glynn
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  3. Donal Reddan
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Correspondence to Donal Reddan.

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Mutwali, A., Glynn, L.G. & Reddan, D. Management of Ischemic Heart Disease in Patients with Chronic Kidney Disease. Am J Cardiovasc Drugs 8, 219–231 (2008). https://doi.org/10.2165/00129784-200808040-00002

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