Abstract
In recent years, the dysfunction of the haemostatic system in relation to the clinical complications from arterioscleroses and cardiovascular diseases has become more recognised. Blood coagulation and fibrinolysis comprise two important physiological systems, which are regulated by a balance between activators and inhibitors. Activation of blood coagulation is associated with accelerated clot formation, whereas activation of blood fibrinolysis enhances the breakdown of the blood clot. Available evidence suggests that strenuous exercise induces activation of blood coagulation with simultaneous enhancement of blood fibrinolysis. Although the responses of blood coagulation and fibrinolysis appear to be related to the exercise intensity and its duration, recent reports suggest that moderate exercise intensity is followed by activation of blood fibrinolysis without concomitant hyper-coagulability, while very intense exercise is associated with concurrent activation of blood coagulation and fibrinolysis. Similar to blood coagulation and fibrinolysis, systemic platelet-related thrombogenic factors have been shown to be involved in the initiation and progression of atherogenesis and plaque growth. Although exercise effects on platelet aggregation and function in healthy individuals have been examined, the results reported have been conflicting. However, for patients with coronary heart disease, the balance of evidence available would strongly suggest that platelet aggregation and functions are increased with exercise. Few studies are available concerning the influence of training on blood coagulation and fibrinolysis and the exact effects of exercise training on the equilibrium between blood coagulation and fibrinolysis is not as yet known. Although the effects of physical training on platelets have been briefly investigated, available meagre evidence suggests that exercise training is associated with favourable effects on platelet aggregation and activation in both men and women.
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References
El-Sayed MS. Effects of exercise on blood coagulation, fibrinolysis and platelet aggregation. Sports Med 1996; 22: 282–98
El-Sayed MS, Sale C, Jones P, et al. Blood haemostasis in exercise and training. Med Sci Sports Exerc 2000; 32: 918–25
Brinkhouse KM, Shermer RW, Mostofi FK. The platelet. Baltimore (MD): William and Wilkins, 1971
Bloom AL, Thomas DP. Haemostasis and thrombosis. New York: Churchill Livingstone, 1981
Arai M, Yorifuji H, Ikematsu S, et al. Influences of strenuous exercise on blood coagulation and fibrinolytic system. Thromb Res 1990; 57: 465–71
Bartsch P, Haeberli A, Straub PW. Blood coagulation after long distance running: antithrombin III prevents fibrin formation. Thromb Haemost 1990; 63: 430–4
Bartsch P, Welsch B, Albert M, et al. Balanced activation of coagulation and fibrinolysis after a 2-h triathlon. Med Sci Sports Exerc 1995; 27: 1465–70
El-Sayed MS, Davies BA. Effect of two formulations of beta-blocker on fibrinolytic response to maximum exercise. Med Sci Sports Exerc 1989; 21: 369–73
Handa K, Terao Y, Mori T, et al. Different coagulability and fibrinolytic activity during exercise depending on exercise intensities. Thromb Res 1992; 66: 613–6
Herren T, Bartsch P, Haeberli A, et al. Increased thrombin-antithrombin III complexes after 1h of physical exercise. J Appl Physiol 1992; 73: 499–504
Molz AB, Heyduck B, Lill H, et al. The effect of different exercise intensities on the fibrinolytic system. Eur J Appl Physiol 1993; 67: 298–304
Ferguson EW, Bernier LL, Banta GR, et al. Effects of exercise and conditioning on clotting and fibrinolytic activity in men. J Appl Physiol 1987; 62: 1416–21
Rocker L, Taenzer M, Drygas WK, et al. Effect of prolonged physical exercise on the fibrinolytic system. Eur J Appl Physiol 1990; 60: 478–81
Hansen JB, Wilsgard L, Olsen JO, et al. Formation and persistence of procoagulant and fibrinolytic activities in circulation after strenuous physical exercise. Thromb Haemost 1990; 64: 385–9
Andrew M, Carter C, O’Brodovich H, et al. Increases in factor VIII complex and fibrinolytic activity are dependent on exercise intensity. J Appl Physiol 1986; 60: 1917–22
El-Sayed MS. Effects of high and low intensity aerobic conditioning programs on blood fibrinolysis and lipid profile. Blood Coagul Fibrinolysis 1996; 7: 484–90
Hoyer LW, Trabold NC. The effect of thrombin on human factor VIII: cleavage of the factor VIII procoagulant protein during activation. J Lab Clin Med 1981; 97: 50–64
Cohen RJ, Epstein SE, Cohen LS, et al. Alterations in blood fibrinolysis and blood coagulation induced by exercise and the role of beta-adrenergic receptor stimulation. Lancet 1968; II: 1264–6
Jilma B, Dirnberger E, Eichner HG, et al. Partial blockade of nitric synthase blunts the exercise-induced increase of von Willebrand factor antigen and of factor VIII in man. Thromb Haemost 1997; 78: 1268–71
Weiss C, Welsch B, Albert M, et al. Coagulation and thrombomodulin in response to exercise of different type and duration. Med Sci Sports Exerc 1998; 30: 1205–10
Hilberg T, Prasa D, Sturzebecher J, et al. Thrombin potential and thrombin generation after exhaustive exercise. Int J Sports Med 2002 Oct; 23(7): 500–4
Weiss C, Velich T, Niebauer J, et al. Activation of coagulation and fibrinolysis after rehabilitative exercise in patients with coronary artery disease. Am J Cardiol 1998; 81: 672–7
Mustonen P, Lepantalo M, Lassila R. Physical exertion induces thrombin formation and fibrin degradation in patients with peripheral atherosclerosis. Arterioscler Thromb Vasc Biol 1998; 18: 244–9
Eriksson-Berg M, Egberg N, Eksborg S, et al. Retained fibrinolytic response and no coagulation activation after acute physical exercise in middle-aged women with previous myocardial infarction. Thromb Res 2002 Mar 15; 105(6): 481–6
Otterstetter R, Szymanski L, Kamimori GH, et al. Hemostatic response to maximal exercise in oral contraceptive users. Am J Obstet Gynecol 1999; 181: 958–63
Weiss C, Bierhaus A, Kinscherf R, et al. Tissue factor-dependent pathway is not involved in exercise-induced formation of thrombin and fibrin. J Appl Physiol 2002; 92: 211–8
Weiss C, Seitel G, Bartsch P. Coagulation and fibrinolysis after moderate and very heavy exercise in healthy male subjects. Med Sci Sports Exerc 1998; 30: 246–51
Schobersberger WB, Wirleitner B, Puschendorf B, et al. Influence of an ultramarathon race at moderate altitude on coagulation and fibrinolysis. Fibrinolysis 1996; 10: 37–42
Gunga HC, Kirsch K, Beneke R, et al. Markers of coagulation, fibrinolysis and angiogenesis after strenuous short-term exercise (Wingate-test) in male subjects of varying fitness levels. Int J Sports Med 2002 Oct; 23(7): 495–9
Prisco D, Paniccia R, Bandinelli B, et al. Evaluation of clotting and fibrinolytic activation after protracted exercise. Thromb Res 1998; 89: 73–8
Dufaux B, Order U, Liesen H. Effect of a short maximal physical exercise on coagulation, fibrinolysis, and complement system. Int J Sports Med 1991; 12: S38–42
Bartsch P, Schmidt EK, Straub W. Fibrinopeptide A after strenuous exercise at high altitude. J Appl Physiol 1982; 53: 40–3
Prisco D, Paniccia R, Guarnaccia V, et al. Thrombin generation after physical exercise. Thromb Res 1993; 69: 159–64
Mandalaki T, Dessypris A, Louizou C, et al. Marathon run I: effects on coagulation, fibrinolysis, platelet aggregation and serum cortisol levels. Thromb Haemost 1992; 43: 49–52
Huisveld IA, Hospers AJH, Bernink MJE, et al. Oral contraceptives and fibrinolysis among female cyclists before and after exercise. J Appl Physiol 1982; 53: 330–4
De Paz JA, Lasierra J, Villa JG, et al. Changes in the fibrinolytic system associated with physical conditioning. Eur J Appl Physiol 1992; 65: 388–93
Ernst E, Koenig W. Fibrinogen and cardiovascular risk. Vasc Med 1997; 2: 115–25
El-Sayed M. Effects of exercise and training on blood rheology. Sports Med 1998; 26: 281–92
El-Sayed M. Fibrinogen levels and exercise: is there a relationship. Sports Med 1996; 21: 402–8
El-Sayed MS, Davies B. Physical conditioning programme does not alter fibrinogen concentration in young healthy subjects. Med Sci Sports Exerc 1995; 27: 485–9
Rankinen T, Vaisanen S, Penttila I, et al. Acute dynamic exercise increases fibrinolytic activity. Thromb Haemost 1995; 73: 281–6
Jootar S, Chaisiripoomkere W, Thaikla O, et al. Effect of running exercise on haematological changes, hematopoietic cells (CFU-GM) and fibrinolytic system in humans. J Med Assoc Thai 1992; 75: 94–8
Suzuki T, Yamauchi K, Yamada Y, et al. Blood coagulability and fibrinolytic activity before and after physical training during the recovery phase of acute myocardial infarction. Clin Cardiol 1992; 15: 358–64
Dill DB, Costill DI. Calculation of percentage changes in volumes of blood, plasma, and red cells in hydration. J Appl Physiol 1974; 37: 247–8
Martin DG, Ferguson EW, Wigutoff S, et al. Blood viscosity responses to maximal exercise in endurance trained and sedentary female subjects. J Appl Physiol 1985; 59: 348–53
Osterud B, Olsen JO, Wilsgard L. Effect of strenuous exercise on blood monocytes and their relation to coagulation. Med Sci Sports Exerc 1989; 21: 374–8
Collen D, Semeraro N, Tricot JP, et al. Turnover of fibrinogen, plasminogen and prothrombin during exercise in man. J Appl Physiol 1977; 42: 865–73
Karp JE, Bell WR. Fibrinogen degradation products and fibrinolysis following exercise in humans. Am J Physiol 1974; 227: 1212–5
Speiser W, Langer W, Pschaick A, et al. Increased blood fibrinolytic activity after physical exercise: comparative study in individuals with different sporting activities and in patients after myocardial infarction taking part in rehabilitation sport program. Thromb Res 1988; 51: 543–55
Van Loon B-JB, Heere LP, Kluft C, et al. Fibrinolytic system during long-distance running in IDDM patients and in healthy subjects. Diabetes Care 1992; 15: 991–6
Ponjee GAE, Janssen EME, Hermans J, et al. Regular physical activity and changes in risk factors for coronary heart disease: a nine months prospective study. Eur J Clin Chem Clin Biochem 1996; 34: 477–83
El-Sayed MS. Exercise intensity-related response of fibrinolytic activity and vasopressin in man. Med Sci Sports Exerc 1990; 22: 494–500
El-Sayed MS, Jones P, Sale C. Exercise induces a change in plasma fibrinogen concentration: fact or fiction? Thromb Res 1999; 96: 467–72
Watts EJ. Haemostatic changes in long-distance runners and their relevance to the prevention of ischaemic heart disease. Blood Coagul Fibrinolysis 1991; 2: 221–5
El-Sayed MS, Lin X, Rattu AJM. Blood coagulation and fibrinolysis at rest and in response to maximal exercise before and after a conditioning programme. Blood Coagul Fibrinolysis 1995; 6: 747–52
Korsan-Bengsten K, Wilhelmsen L, Tibblin G. Blood coagulation and fibrinolysis in relation to degree of physical activity during work and leisure time. Acta Med Scand 1973; 193: 73–7
Boman K, Hellsten G, Bruce A, et al. Endurance physical activity, diet and fibrinolysis. Atherosclerosis 1994; 106: 65–74
Van den Burg PJM, Hospers JE, van Vliet M, et al. Effect of endurance training and seasonal fluctuation on coagulation and fibrinolysis in young sedentary men. J Appl Physiol 1997; 82: 613–20
Van den Burg PJ, Hospers JE, Mosterd WL, et al. Aging, physical conditioning, and exercise-induced changes in hemostatic factors and reaction products. J Appl Physiol 2000 May; 88(5): 1558–64
Worsornu D, Allardyce W, Ballantyne D, et al. Influence of power and aerobic exercise training on haemostatic factors after coronary artery surgery. Br Heart J 1992; 68: 181–6
Stratton JR, Chandler WL, Schwartz RS, et al. Effects of physical conditioning on fibrinolytic variables and fibrinogen in young and old healthy adults. Circulation 1991; 83: 1692–7
Schuit AJ, Schouten EG, Kluft C, et al. Effect of strenuous exercise on fibrinogen and fibrinolysis in healthy elderly men and women. Thromb Haemost 1997; 78: 845–51
DeSouza CA, Paker-Jones P, Seals DR. Physical activity status and adverse age-related differences in coagulation and fibrinolytic factors in women. Arterioscler Thromb Vasc Biol 1998; 18: 362–8
Dunstan DW, Mori TA, Puddey IB, et al. A randomised, controlled study of the effects of aerobic exercise and dietary fish on coagulation and fibrinolytic factors in type 2 diabetics. Thromb Haemost 1999 Mar; 81(3): 367–72
Barbeau P, Litaker MS, Woods KF, et al. Hemostatic and inflammatory markers in obese youths: effects of exercise and adiposity. J Pediatr 2002 Sep; 141(3): 415–20
Chandler WL. The human fibrinolytic system. Crit Rev Oncol Hematol 1996; 24: 27–45
Dooijewaard G, DeBoer AD, Turion PNC, et al. Physical exercise induces enhancement of urokinase-type plasminogen activator (u-PA) levels in plasma. Thromb Haemost 1991; 65: 82–6
Van den Burg PJM, Dooijewaard G, Van Vliet M, et al. Differences in u-PA and t-PA increase during acute exercise: relation with exercise parameters. Thromb Haemost 1994; 71: 236–9
Davis GL, Abildgaard CT, Bernauer EM, et al. Fibrinolytic and hemostatic changes during and after maximal exercise in males. J Appl Physiol 1976; 40: 287–92
De Paz JA, Villa JG, Vilades EM, et al. Effects of oral contraceptives on fibrinolytic response to exercise. Med Sci Sports Exerc 1995; 27: 961–6
Gough SC, Whitworth LS, Rice PJS, et al. The effect of exercise and heart rate on fibrinolytic activity. Blood Coagul Fibrinolysis 1992; 3: 179–82
Szymanski LM, Pate RR. Effect of exercise intensity, duration, and time of day on fibrinolytic activity in physically active men. Med Sci Sports Exerc 1994; 26: 1102–8
Szymanski LM, Pate RR, Durstine JL. Effects of maximal exercise and venous occlusion on fibrinolytic activity in physically active and inactive men. J Appl Physiol 1994; 77: 2305–10
El-Sayed MS. Fibrinolytic and hemostatic parameters response after resistance exercise. Med Sci Sports Exerc 1993; 25: 597–602
Vind J, Gleerup G, Nielsen PT, et al. The impact of static work on fibrinolysis and platelet function. Thromb Res 1993; 72: 441–61
Jansson JH, Johansson B, Boman K, et al. Hypofibrinolysis in patients with hypertension and elevated cholesterol. J Intern Med 1991; 229: 309–16
Rydzewski A, Sakata K, Kobayashi A, et al. Changes in plasminogen activator inhibitor 1 and tissue-type plasminogen activator during exercise in patients with coronary artery disease. Haemostasis 1990; 20: 305–12
El-Sayed MS. Extrinsic plasminogen activator response to exercise after a single dose of propranolol. Med Sci Sports Exerc 1992; 24: 327–32
Fernhall B, Szymanski LM, Gorman PA, et al. Both atenolol and propranolol blunt the fibrinolytic response to exercise but not resting fibrinolytic potential. Am J Cardiol 2000; 86: 1398–400
Stegnar MP, Paeternel P, Chen JP. Acute hypoxia does not increase blood fibrinolytic activity in man. Thromb Res 1987; 45: 333–43
Bounameaux H, Righetti A, Moerloose PD, et al. Effects of exercise test on plasma markers of an activation of coagulation and/or fibrinolysis in patients with symptomatic or silent myocardial ischemia. Thromb Res 1992; 65: 27–32
Marsh NA, Gafney PJ. Exercise-induced fibrinolysis: fact or fiction? Thromb Haemost 1982; 48: 201–3
Hamsten A. The hemostatic system and coronary heart disease. Thromb Res 1993; 70: 1–38
Leon AS, Myers MJ, Connett J. Leisure-time physical activity and the 16-year risk of mortality from CHD and all-causes in the Multiple Risk Factor Intervention Trial (MRFIT). Int J Sports Med 1997; 18: S208–15
McMurray RG, Ainsworth BE, Harrell JS, et al. Is physical activity or aerobic power more influential on reducing cardiovascular disease risk factors? Med Sci Sports Exerc 1998; 30: 1521–9
Shaper AG, Wannamethee G. Physical activity and ischaemic heart disease in middle-aged men. Br Heart J 1991; 66: 384–9
De Geus EJC, Kluft C, De Bart ACW, et al. Effects of exercise training on plasminogen activator inhibitor activity. Med Sci Sports Exerc 1992; 24: 1210–9
Gris JC, Schved JF, Feugeas O, et al. Impact of smoking, physical training and weight reduction on FVIII, PAI-1 and haemostatic markers in sedentary men. Thromb Res 1990; 64: 516–20
Schneider SH, Kim HC, Khachadurian AK, et al. Impaired fibrinolytic response to exercise in type II diabetes: effects of exercise and physical training. Metabolism 1988; 37: 924–9
Hornsby WG, Boggess KA, Lyons TJ, et al. Hemostatic alterations with exercise conditioning in NIDDM. Diabetes Care 1990; 13: 87–92
Estelles A, Aznar J, Torino G, et al. Influence of a rehabilitation sports programme on the fibrinolytic activity of patients after myocardial infarction. Thromb Res 1989; 55: 203–12
Philips DR, Shuman MA. Biochemistry of platelets. Florida: Academic Press INC, 1986
El Sayed M. Effects of alcohol ingestion post-exercise on platelet aggregation. Thromb Res 2002; 105: 1–5
Bourey RE, Santoro SA. Interaction of exercise, coagulation, platelets, and fibrinolysis: a brief review. Med Sci Sports Exerc 1988; 20: 439–46
Dawson AA, Ogston D. Exercise-induced thrombocytosis. Acta Haematol 1969; 42: 241–6
Schaffner A, Augustiny N, Otto RC, et al. The hypersplenic spleen: a contractile reservoir of granulocyte and platelets. Arch Intern Med 1985; 40: 55–61
Peters AM. Just how big is the pulmonary granulocyte pool? Clin Sci 1997; 94: 7–19
Mittleman MA, Maclure M, Tofler GH, et al. Triggering of acute myocardial infarction by heavy physical exertion. N Engl J Med 1993; 329: 1677–83
El-Sayed MS. Exercise and training effects on platelets in health and disease. Platelets 2002; 13: 261–6
Kestin AS, Ellis PA, Barnard MR, et al. Effect of strenuous exercise on platelet activation state and reactivity. Circulation 1993; 88: 1502–11
Mockel M, Ulrich NV, Heller Jr G, et al. Platelet activation through triathlon competition in ultra-endurance trained athletes: impact of thrombin and plasmin generation and catecholamine release. Int J Sports Med 2001; 22: 337–43
Hilberg T, Schmidt V, Losche W, et al. Platelet activity and sensitivity to agonists after exhaustive treadmill exercise. J Sports Sci Med 2003; 2: 15–22
Michelson AD, Barnard MR, Hechman HB, et al. In vivo tracking of platelets: circulating degranulated platelets rapidly lose surface-P-selectin but continue to circulate and function. Proc Natl Acad Sci U S A 1996; 93: 11877–82
Rocker L, Gunay S, Gunga HC, et al. Activation of blood platelets in response to maximal isometric exercise of the dominant arm. Int J Sports Med 2000; 21: 191–4
Ahmadizad S, El-Sayed M. The effect of graded resistance exercise on platelet aggregation and activation. Med Sci Sports Exerc 2003; 35: 1026–32
Hurlen M, Seljeflot I, Amesen H. Increased platelet aggregability during exercise in patients with myocardial infarction: lack of inhibition by aspirin. Thromb Res 2000; 99: 487–94
Mant MJ, Kappagoda CT, Quinlan J. Lack of effect of exercise on platelet activation and platelet reactivity. J Appl Physiol 1984; 57: 1333–7
Li N, Hakan NH. Evidence for prothrombotic effects of exercise and limited protection by aspirin. Circulation 1999; 1000: 1374–9
Wallen NH, Goodall AH, Li N, et al. Activation of haemostasis by exercise, mental stress and adrenaline: effects on platelet sensitivity to thrombin and thrombin generation. Clin Sci (Lond) 1999; 97: 27–35
Ikarugi H, Taka T, Nakajima S, et al. Norepinephrine, but not epinephrine, enhances platelet reactivity and coagulation after exercise in humans. J Appl Physiol 1999; 86: 133–8
Rock G, Tittley P, Pipe A. Coagulation factor changes following endurance exercise. Clin J Sport Med 1997; 7: 94–9
Ikarugi H, Taka T, Nakajima S, et al. Detection of a prothrombotic state after acute aerobic exercise. Thromb Res 1997; 85: 351–6
Wang JS, Cheng LJ. Effect of strenuous, acute exercise on alpha2-adrenergic agonist-potentiated platelet activation. Arterioscler Thromb Vasc Biol 1999; 19: 1559–65
Gawel MJ, Glover M, Burkitt M, et al. The specific activity of platelet monoamine oxidase varies with platelet count during severe exercise and noradrenaline infusion. Psychopharmacology 1981; 72: 275–7
Haber P, Siblerbauer K, Sinzinger H. Quantitative studies on reversible thrombocyte aggregation during exertion. Schweiz Med Wochenschr 1980; 110: 1488–91
Andreotti F, Lanza GA. Platelet activation with exercise in coronary disease: is it ischemia or atherosclerosis? Cardiologia 1999; 44: 997–9
Arosio E, Minuz P, Prior M, et al. Vascular adhesion molecule-1 and markers of platelet function before and after treatment with iloprost or a supervised physical exercise programme in patients with peripheral arterial disease. Life Sci 2001; 69: 421–33
Gibbs CR, Blann AD, Edmunds E, et al. Effects of acute exercise on hemorheological, endothelial, and platelet markers in patients with chronic heart failure in sinus rhythm. Clin Cardiol 2001; 24: 724–9
Lanza GA, Andreotti F, Sestito A, et al. Platelet aggregability in cardiac syndrome X. Eur Heart J 2001; 22: 1924–30
Andreotti F, Lanaza GA, Sciahbasi A, et al. Low grade exercise enhances platelet aggregability in patients with obstructive coronary disease independently of myocardial ischamia. Am J Cardiol 2001; 87: 16–20
Sakita S, Kishi Y, Numano F. Acute vigorous exercise attenuates sensitivity of platelet to nitric oxide. Thromb Res 1997; 87: 461–71
Tozzi-Ciancarelli MG, Penco M, Di Massimo C. Influence of acute exercise on human platelet responsiveness: possible involvement of exercise-induced oxidative stress. Eur J Appl Physiol 2002; 86: 266–72
Constans J, Seigneur M, Blann AD, et al. Endothelial function, platelet activation and coagulation in lower limb occlusive arterial disease during treadmill exercise: correlations with transcutaneous oxygen pressure. Thromb Res 2000; 99: 557–61
Hsu HC, Lee YT, Chen MF. Exercise shifts the platelet aggregation modulatory role from native to mildly oxidized low-density lipoprotein. Med Sci Sports Exerc 2000; 32: 933–9
Di Massimo C, Taglieri G, Penco M, et al. Influence of ageing and exercise-induced stress on human platelet function. Clin Hemorheol Microcirc 1999; 20: 105–10
Lindemann S, Klingel B, Fisch B, et al. Increased platelet sensitivity toward platelet inhibitor during physical exercise in patients with coronary artery disease. Thromb Res 1999; 93: 51–9
Li-Shaw-Hee FL, Blann AD, Edmunds E, et al. Effect of acute exercise on the raised plasma fibrinogen, soluble P-Selectin and von Willebrand factor levels in chronic atrial fibrillation. Clin Cardiol 2001; 24: 409–14
Furui H, Tanigucji N, Yamauchi K, et al. Effects of treadmill exercise on platelet function, blood coagulation and fibrinolytic activity in patients with atrial fibrillation. Jpn Heart J 1987; 28: 177–84
Bartsch P. Platelet activation with exercise and risk of cardiac events. Lancet 1999; 354: 1747–8
Wang JS, Jen CJ, Chen HI. Effects of exercise training and deconditioning on platelet function in men. Arterioscler Thromb Vasc Biol 1995; 15: 1668–74
Wang JS, Jen CJ, Chen HI. Effects of chronic exercise and deconditioning on platelet function in women. J Appl Physiol 1997; 83: 2080–5
Rauramaa R, Salonen JT, Seppanen K. Inhibition of platelet aggregability by moderate intensity physical exercise: a randomised clinical trial in overweight men. Circulation 1986; 74: 939–44
Davis RB, Boyd DG, McKinney ME, et al. Effects of exercise and conditioning on blood platelet function. Med Sci Sports Exerc 1990; 22: 49–53
Gonzales F, Manas M, Seiquer I, et al. Blood platelet function in healthy individuals of different ages: effects of exercise and exercise deconditioning. J Sports Med Phys Fitness 1996; 36: 112–6
Wang JS, Yang CF, Wong MK, et al. Effect of strenuous arm exercise on oxidized-LDL-potentiated platelet activation in individuals with spinal cord injury. Thromb Haemost 2000; 84: 118–23
Rauramaa R, Li G, Vaisanen B. Dose-response and coagulation and hemostatic factors. Med Sci Sports Exerc 2001; 33: 516–20
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El-Sayed, M.S., El-Sayed Ali, Z. & Ahmadizad, S. Exercise and Training Effects on Blood Haemostasis in Health and Disease. Sports Med 34, 181–200 (2004). https://doi.org/10.2165/00007256-200434030-00004
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DOI: https://doi.org/10.2165/00007256-200434030-00004