Comparison of a Combination Ferrous Fumarate Product and a Polysaccharide Iron complex as Oral Treatments of Iron Deficiency Anemia: A Taiwanese Study
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
Despite efforts to improve iron supplements for iron deficiency anemia, there is no consensus on products that balance efficacy, safety and tolerability, and cost. Ferrous products are effective, but they are associated with more gastrointestinal side effects than ferric products. Ferric products tend to have lower absorption. We present results from a 12-week study that ran domized 72 people with uncomplicated iron deficiency anemia to receive a ferrous iron supplement (Ferall, a combination of ferrous fumarate with ascorbic acid, folic acid, and cyanocobalamin) or a ferric iron polysaccharide complex (Niferex, ferro-glycine sulfate) plus ascorbic acid. The ferrous product was significantly more effective, the primary and secondary endpoints including changes in levels of hemoglobin and serum ferritin. There was a slightly higher frequency of gastrointestinal side effects in patients taking the ferrous product, but both supplements were well tolerated. No participant withdrew from the study because of side effects. We concluded that the ferrous product is safe and effective for use in uncomplicated iron deficiency anemia. The lack of direct comparison between single-agent ferrous fumarate and the combination ferrous product limited interpretation of results in terms of possible effects due to other components, such as ascorbic acid.
- Brittenham G. Disorders of iron metabolism: iron deficiency and overload. In: Hoffman R, Benz EJ Jr, Shattil SJ, et al, eds. Hematology: Basic Principles and Practice. 3rd ed. New York: Churchill Livingstone; 2000:397–428.
- Fisher A, Naughton D. Iron supplements: the quick fix with long- term consequences. Nutr J. 2004;3:2. CrossRef
- Glassman E. Oral iron therapy with ferrous fumarate and polysac- charide iron complex. ANNA J. 1992;19:277–278,323.
- Tinawi M, Martin K, Bastani B. Oral iron absorption test in patients with CAPD: comparison of ferrous sulfate and a polysac- charide ferric complex. Nephron. 1996;74:291–294. CrossRef
- Comparison of a Combination Ferrous Fumarate Product and a Polysaccharide Iron complex as Oral Treatments of Iron Deficiency Anemia: A Taiwanese Study
International Journal of Hematology
Volume 80, Issue 5 , pp 416-420
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Iron deficiency anemia
- Iron supplementation
- Industry Sectors