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Solvent-free synthesis of 6-unsubstituted dihydropyrimidinones using 2-pyrrolidonium bisulphate as efficient catalyst

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Abstract

A one-pot three-component Biginelli-like reaction of enaminones, aldehydes with urea/thiourea in the presence of 2-pyrrolidonium bisulphate as an acidic ionic liquid catalyst for the preparation of 6-unsubstituted dihydropyrimidinones is described. The excellent yield, short reaction time, simple procedure and avoidance of the use of organic solvents are some advantages of this method.

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Authors and Affiliations

  1. Faculty of Chemistry, University of Mazandaran, University Street, 47416-95447, Babolsar, Iran

    Heshmatollah Alinezhad, Mahmood Tajbakhsh & Mahbooeh Mousavi

  2. Faculty of Science and Herbs, Amol University of Special Modern Technologies, Taleghani Street, 16846-13114, Amol, Iran

    Mahboobeh Zare

Authors
  1. Heshmatollah Alinezhad
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  2. Mahmood Tajbakhsh
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  3. Mahboobeh Zare
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  4. Mahbooeh Mousavi
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Correspondence to Heshmatollah Alinezhad.

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Alinezhad, H., Tajbakhsh, M., Zare, M. et al. Solvent-free synthesis of 6-unsubstituted dihydropyrimidinones using 2-pyrrolidonium bisulphate as efficient catalyst. Chem. Pap. 70, 1126–1130 (2016). https://doi.org/10.1515/chempap-2016-0048

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