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A facile, highly efficient and novel method for synthesis of 5-substituted 1H-tetrazoles catalysed by copper(I) chloride

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Abstract

The present study on tetrazole compounds, which have a wide area of application, proposes a new, simple and highly effective method. A series of 5-substituted 1H-tetrazoles were synthesised in DMF via the [3 + 2] cycloaddition reaction, in which different aryl nitriles with sodium azide were used and copper(I) chloride served as a catalyst. Short reaction times, high yields and simple procedures rendered this method attractive and useful for the organic synthesis of 5-substituted 1H-tetrazoles. A further advantage was the use of an environmentally friendly catalyst.

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Authors and Affiliations

  1. Chemistry Department, Faculty of Arts and Science, Dumlupınar University, Evliya Çelebi Campus, 43100, Kütahya, Turkey

    İbrahim Esirden & Erhan Başar

  2. Biochemistry Department, Faculty of Arts and Science, Dumlupınar University, Evliya Çelebi Campus, 43100, Kütahya, Turkey

    Muharrem Kaya

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  1. İbrahim Esirden
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  2. Erhan Başar
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  3. Muharrem Kaya
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Correspondence to Muharrem Kaya.

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Esirden, İ., Başar, E. & Kaya, M. A facile, highly efficient and novel method for synthesis of 5-substituted 1H-tetrazoles catalysed by copper(I) chloride. Chem. Pap. 69, 1231–1236 (2015). https://doi.org/10.1515/chempap-2015-0124

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