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Ovulation block by Pueraria mirifica

A study of its endocrinological effect in female monkeys

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Abstract

Pueraria mirifica (PM), a Thai herb containing phytoestrogens, may act as estrogen and disturb reproduction. To investigate the effect of PM on the menstrual cycle length and related hormones, nine adult female monkeys (Macaca fascicularis) were separated into three groups. Each group (n=3) was fed with 10, 100, and 1000 mg/d of PM for three menstrual cycles. The menstrual cycle length increased significantly in monkeys treated with PM-10 and PM-100 and disappeared completely in monkeys treated with PM-1000. Serum follicle stimulating hormone, luteinizing hormone, estradiol, progesterone, and ir-inhibin were lower during the treatment period in a dose-dependent manner. Changes in menstrual cycle length and the hormonal levels recovered during the post-treatment period only in monkeys treated with PM-10 and PM-100. PM greatly influences menstrual cycles and may suppress ovulation by lowering serum levels of gonadotropins.

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Authors and Affiliations

  1. Department of Physiology, Faculty of Medicine, Srinakharinwirot University, 10110, Bangkok, Thailand

    Hataitip Trisomboon

  2. Primate Research Unit, Department of Biology, Faculty of Science, Chulalongkorn University, 10330, Bangkok, Thailand

    Hataitip Trisomboon & Suchinda Malaivijitnond

  3. Laboratory of Veterinary Physiology, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, 183-8509, Tokyo, Japan

    Gen Watanabe & Kazuyoshi Taya

  4. Department of Basic Veterinary Science, The United Graduate School of Veterinary Science, Gifu University, 501-1193, Gifu, Japan

    Gen Watanabe & Kazuyoshi Taya

Authors
  1. Hataitip Trisomboon
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  2. Suchinda Malaivijitnond
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  3. Gen Watanabe
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  4. Kazuyoshi Taya
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Correspondence to Suchinda Malaivijitnond.

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Trisomboon, H., Malaivijitnond, S., Watanabe, G. et al. Ovulation block by Pueraria mirifica . Endocr 26, 33–39 (2005). https://doi.org/10.1385/ENDO:26:1:033

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  • DOI: https://doi.org/10.1385/ENDO:26:1:033

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