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Significance of serum trace element status in patients with rheumatic heart disease

A prospective study

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Abstract

It is known that certain trace elements can affect various heart diseases. In this study, we aimed to evaluate the changes in concentrations of certain serum trace elements in patients with chronic rheumatic heart disease (RHD). Serum analysis of selenium (Se), zinc (Zn), and copper (Cu) trace elements was assayed by atomic absorption spectrophotometry. RHD patients had significantly lower serum concentrations of Se and Zn than control subjects (p<0.05 and p<0.001, respectively). However, the serum Cu concentration was significantly higher in RHD patients than in controls (1.93±0.59 μg/L vs 1.06±0.29 μg/L; p<0.001). Similarly, the Cu/Zn ratio in RHD patients was higher than in control subjects (4.70±0.92 vs 1.68±0.45; p<0.001). Additionally, no significant correlation was found among these trace element concentrations and the functional capacity classes (p>0.05). RHD patients had decreased serum Se and Zn element concentrations and increased serum Cu element concentration. We suggest that Se and Zn deficiency might be contributory factors in the development of rheumatic heart disease, and a high Cu concentration and a high Cu/Zn ratio might reflect an ongoing inflammatory process in this disease.

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References

  1. O. Oster and W. Prellwitz, Selenium and cardiovascular disease, Biol. Trace. Element Res. 24, 91–103 (1990).

    Article  CAS  Google Scholar 

  2. N. Bai-song, L. Chun-seng, and C. Li-hua, Significance of low levels of blood selenium in dilated cardiomyopathy, Chin. Med. 99, 948–954 (1986).

    Google Scholar 

  3. O. Oster, Trace element concentrations (Cu, Zn, Fe) in sera from patients with dilated cardiomyopathy. Clin. Chim. Acta 214, 209–218 (1993).

    Article  PubMed  CAS  Google Scholar 

  4. O. Oster, M. Dahm, H. Oelert, and W. Prellwitz, Concentrations of some trace elements (Se, Zn, Cu, Fe, Mg, K) in blood and heart tissue of patients with coronary heart disease, Clin. Chem., 35, 851–856 (1989).

    PubMed  CAS  Google Scholar 

  5. P. N. Hopkins and P. R. Williams, A survey of 246 suggested coronary risk factors, Atherosclerosis 40, 1–52 (1981).

    Article  PubMed  CAS  Google Scholar 

  6. L. M. Klevay, The role of copper, zinc and other chemical elements in ischemic heart disease, in Metabolism of Trace Metals in Man, Volume 1, O. M. Rennert and W. Y. Chan, eds., CRC, Boca Raton, FL, pp. 129–157 (1984).

    Google Scholar 

  7. I. Durak, O. Akyol, M. U. Es, O. Canbolat, and A. Akpoyraz, Element structure in stenotic mitral valves, Am. J. Cardiol. 71, 355 (1993).

    Article  PubMed  CAS  Google Scholar 

  8. S. K. Bhattacharya and R. K. Gupta, Zinc in rheumatic heart valves, J. Assoc. Physicians India 43, 72 (1995).

    PubMed  CAS  Google Scholar 

  9. C. Nystrom-Rosander, U. Lindh, G. Friman, O. Lindqvist, S. Thelin, and N. G. Ilback, Trace element changes in sclerotic heart valves from patients are expressed in their blood, Biometals 17, 121–128 (2004).

    Article  PubMed  Google Scholar 

  10. V. Govindaraju, N. Prabhudev, M. Gurappa, V. S. Jawali, P. M. Chandrasekhara, and C. N. Manjunath, Zinc in rheumatic heart valves, J. Assoc. Physicians India 41, 653–654 (1993).

    PubMed  CAS  Google Scholar 

  11. T. Rotruck, A. L. Pope, H. E. Ganther, A. B. Swanson, D. G. Hafeman, and W. G. Hoekstra, Selenium biochemical role as a component of glutathione peroxidase, Science 179, 588–590 (1973).

    Article  PubMed  CAS  Google Scholar 

  12. G. M. Rubanyi, Vascular effects of oxygen-derived free radicals, Free Radical Biol. Med. 4, 107–120 (1988).

    Article  CAS  Google Scholar 

  13. J. E. Spallholz, L. M. Boylan, and H. S. Larsen, Advances in understanding selenium's role in the immun system, Ann. NY Acad. Sci. 587, 123–139 (1990).

    PubMed  CAS  Google Scholar 

  14. L. Kiremidjian and G. Stotzky, Selenium and immune response, Environ. Med. 42, 277–285 (1987).

    Google Scholar 

  15. T. M. Bray and W. J. Bettger, The physiological role of zinc as an antioxidant, Free Radical Biol. Med. 8, 281–291 (1990).

    Article  CAS  Google Scholar 

  16. U. Deuschle and U. Weser, Copper and inflammation, Prog. Clin. Biochem. Med. 2, 97–130 (1985).

    CAS  Google Scholar 

  17. R. K. Chandra, Trace element regulation of immunity and infection, J. Am. Coll. Nutr. 4, 5–16 (1985).

    PubMed  CAS  Google Scholar 

  18. M. C. Argino, M. M. Lavin, and P. A. Reyes, Acute rheumatic fever, Rheum. Dis. Clin. North Am. 19, 330–350 (1993).

    Google Scholar 

  19. D. J. Burge and R. J. De Horatius, Acute rheumatic fever, Cardiovasc. Clin. 23, 3–23 (1993).

    PubMed  CAS  Google Scholar 

  20. M. S. Bronze and J. B. Dale, The reemergence of serious group A treptococcal infections and rheumatic fever, Am. J. Med. Sci. 311, 41–54 (1996).

    Article  PubMed  CAS  Google Scholar 

  21. I. Goldstein, B. Halpern, and L. Robert, Immunologic relationship between streptococcus A polysaccharide and the structural glycoproteins of heart valve, Nuture 213, 44–47 (1967).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Cardiology, Inonu University, Faculty of Medicine, Turgut Ozal Medical Center, Malatya, Turkey

    Feridun Kosar, Nusret Acikgöz, Yuksek Aksoy & Sengul Cehreli

  2. Department of Internal Medicine, Inonu University, Faculty of Medicine, Turgut Ozal Medical Center, Malatya, Turkey

    Ibrahim Sahin

  3. Department of Analytical Chemistry, Inonu University, Faculty of Medicine, Turgut Ozal Medical Center, Malatya, Turkey

    Zehra Kucukbay

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  1. Feridun Kosar
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  2. Ibrahim Sahin
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  3. Nusret Acikgöz
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  4. Yuksek Aksoy
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  5. Zehra Kucukbay
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  6. Sengul Cehreli
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Correspondence to Feridun Kosar.

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Kosar, F., Sahin, I., Acikgöz, N. et al. Significance of serum trace element status in patients with rheumatic heart disease. Biol Trace Elem Res 107, 1–9 (2005). https://doi.org/10.1385/BTER:107:1:001

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  • DOI: https://doi.org/10.1385/BTER:107:1:001

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