Article

Immunologic Research

, Volume 25, Issue 1, pp 75-95

Interactions of integrins with their partner proteins in leukocyte membranes

  • Howard R. PettyAffiliated withDepartment of Biological Sciences, Wayne State UniversityDivision of Hematology/Oncology, University of Pennsylvania School of MedicineDivision of Hematology/Oncology, University of Michigan School of Medicine
  • , Randall G. WorthAffiliated withDepartment of Biological Sciences, Wayne State UniversityDivision of Hematology/Oncology, University of Pennsylvania School of MedicineDivision of Hematology/Oncology, University of Michigan School of Medicine
  • , Robert F. ToddIIIAffiliated withDepartment of Biological Sciences, Wayne State UniversityDivision of Hematology/Oncology, University of Pennsylvania School of MedicineDivision of Hematology/Oncology, University of Michigan School of Medicine

Abstract

Integrins participate in many aspects of immunologic and inflammatory responses, especially those involving cell migration, adherence, and activation. Although leukocyte integrins such as complement receptor type 3 (CR3) are known to carry out certain functions without the intervention of other plasma membrane receptors, many plasma membrane proteins are now known to physically interact and functionally cooperate with integrins. Several of these interactions are highly dynamic within cell membranes; thus integrin-partner protein interactions change during certain physiological processes. This allows an extraordinary adaptability of the system to prime and promote proinflammatory signaling. Since our discovery of the CR 3-FcyRIIIB interaction, the plasma membrane protein repertoire of β1, β2, and β3 integrins has grown to include: FcγRIIA (CD32), uPAR (urokinase-type plasminogen activator receptor; CD87), CD14, voltage-gated K+ channels (Kvl.3), integrin-associated protein (IAP), CD98, tetraspans (TM4SF), insulin receptors, and PDGFβ receptors. In this article we will highlight certain features of this growing field of research, especially with regard to their relevance in immunology and inflammation.

Key Words

Integrins CR3 Adherence receptors GPI-linked proteins Urokinase receptors Fcγ receptors Tetraspans Potassium channels Receptor-receptor interactions