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Hyperparathyroidism secondary to hypovitaminosis D in hypoalbuminemic is less intense than in normoalbuminemic patients

A prevalence study in medical inpatients in southern Brazil

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Abstract

Hypovitaminosis D has been reported in tropical countries, but this hormone has seldom been studied in Brazil. Our purpose was to study the prevalence of hypovitaminosis D in patients hospitalized in internal medicine wards in Southern Brazil. Possible associated factors were studied. We studied 81 adult patients in early spring. Mean serum 25(OH)D was 12±8.57 ng/mL; hypovitaminosis D was severe (<10 ng/mL) in 27 (33.3%) patients, and moderate (≥10 ng/mL and <20 ng/mL) in 36 (44.5%) patients. Clinical evaluation did not yield any data associated with hypovitaminosis D. Serum 25(OH)D levels of up to 20 ng/mL were associated with decreased mean serum total calcium (p=0.001), ionized calcium (p=0.01), and phosphorus (p=0.044) levels, and increased mean serum PTH level (p=0.001). In a multiple regression model, serum PTH level was independently affected by serum total calcium (p=0.01), phosphorus (p=0.009), and albumin (p=0.009) levels. Hypovitaminosis D patients had lower mean serum albumin levels (p=0.004), and serum 25(OH)D levels were directly correlated to serum albumin levels (p<0.0001). Albumin influenced independently PTH response to hypovitaminosis D; normoalbuminemic hypovitaminosis D patients had higher mean serum PTH than hypoalbuminemic patients. Conclusion: Hypovitaminosis D prevalence was very high in medical inpatients in Southern Brazil, in early spring. Nevertheless, secondary hyperparathyroidism was less intense in hypoalbuminemic hypovitaminosis D patients suggesting that in these patients free serum 25(OH)D was closer to normal.

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Authors and Affiliations

  1. Division of Internal Medicine, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil, Rua Ramiro Barcellos 2350/700, 90035-003, Porto Alegre, RS, Brazil

    Melissa Orlandin Premaor, Gustavo Vasconcelos Alves & Tania Weber Furlanetto MD, PhD

  2. Clinical Pathology, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil, Rua Ramiro Barcellos 2350/700, 90035-003, Porto Alegre, RS, Brazil

    Ligia Beatriz Crossetti

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  1. Melissa Orlandin Premaor
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  2. Gustavo Vasconcelos Alves
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  3. Ligia Beatriz Crossetti
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  4. Tania Weber Furlanetto MD, PhD
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Correspondence to Tania Weber Furlanetto MD, PhD.

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Premaor, M.O., Alves, G.V., Crossetti, L.B. et al. Hyperparathyroidism secondary to hypovitaminosis D in hypoalbuminemic is less intense than in normoalbuminemic patients. Endocr 24, 47–53 (2004). https://doi.org/10.1385/ENDO:24:1:047

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  • DOI: https://doi.org/10.1385/ENDO:24:1:047

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