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Prognosis of Fibrosarcoma in Patients With and Without a History of Radiation for Nasopharyngeal Carcinoma

  • Bone and Soft Tissue Sarcomas
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Purpose

To determine whether radiation-induced fibrosarcoma (RIF) in patients with a history of radiotherapy for nasopharyngeal carcinoma (NPC) was associated with an inferior prognosis compared to sporadic fibrosarcoma of the head and neck.

Methods

Forty-two patients with RIF who previously received radiotherapy for NPC and 124 patients with sporadic fibrosarcoma of the head and neck were identified between January 1965 and December 2013 at our institution. Information on clinicopathologic characteristics and treatment was abstracted from medical records. The primary end point was disease-specific survival (DSS).

Results

The median latency from NPC diagnosis to RIF diagnosis was 9.9 years (range 3.1–36.8 years). RIF was diagnosed at an older age than sporadic fibrosarcoma. Treatment modality was significantly different between the two groups, with only 64.3 % of the RIF group receiving surgery ± adjuvant treatment versus 91.1 % in the sporadic fibrosarcoma group (P < 0.001). Patients with RIF had poorer 5-year DSS compared to the sporadic fibrosarcoma group (36.2 vs. 50.4 %; P = 0.026). Multivariate analysis of the combined group indicated that patient group (P = 0.032), tumor, node, metastasis classification system stage (P = 0.019), histologic grade (P = 0.046) and treatment modality (P < 0.001) were independent variables affecting DSS.

Conclusions

Compared to patients with sporadic fibrosarcoma, NPC survivors who develop RIF are older at diagnosis of fibrosarcoma and have an inferior prognosis.

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Acknowledgment

Supported in part by grants from the Sci-Tech Project Foundation of Guangdong Province (2012B061700083) and the National Natural Science Foundation of China (81201748).

Disclosure

The authors declare no conflict of interest.

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Author notes

    Authors and Affiliations

    1. State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China

      Peng Zhang MD, Lei Zhao MD, Yu-Jia Zhu MD, Bo Qiu MD, Su-Ping Guo MS, Yong Li MD, Meng-Zhong Liu MD & Mian Xi MD

    2. Department of Radiation Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China

      Peng Zhang MD, Lei Zhao MD, Yu-Jia Zhu MD, Bo Qiu MD, Su-Ping Guo MS, Meng-Zhong Liu MD & Mian Xi MD

    3. Department of Pathology, Cancer Center, Sun Yat-Sen University, Guangzhou, China

      Yong Li MD

    4. Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, China

      Qing Liu MD

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    1. Peng Zhang MD
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    Correspondence to Mian Xi MD.

    Additional information

    Peng Zhang and Lei Zhao contributed equally to this work.

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    Zhang, P., Zhao, L., Zhu, YJ. et al. Prognosis of Fibrosarcoma in Patients With and Without a History of Radiation for Nasopharyngeal Carcinoma. Ann Surg Oncol 24, 434–440 (2017). https://doi.org/10.1245/s10434-016-5589-1

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    • DOI: https://doi.org/10.1245/s10434-016-5589-1

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