Annals of Surgical Oncology

, Volume 14, Issue 9, pp 2628–2635

Overexpression of RhoE Has a Prognostic Value in Non–Small Cell Lung Cancer

Authors

  • Cuiyan Zhang
    • Department of Thoracic SurgeryPeking Union Medical College, Chinese Academy of Medical Sciences
  • Fang Zhou
    • Department of Thoracic SurgeryPeking Union Medical College, Chinese Academy of Medical Sciences
  • Ning Li
    • Department of Thoracic SurgeryPeking Union Medical College, Chinese Academy of Medical Sciences
  • Susheng Shi
    • PathologyCancer Hospital (Institute), Peking Union Medical College, Chinese Academy of Medical Sciences
  • Xiaoli Feng
    • PathologyCancer Hospital (Institute), Peking Union Medical College, Chinese Academy of Medical Sciences
  • Zhaoli Chen
    • Department of Thoracic SurgeryPeking Union Medical College, Chinese Academy of Medical Sciences
  • Jie Hang
    • Department of Thoracic SurgeryPeking Union Medical College, Chinese Academy of Medical Sciences
  • Bin Qiu
    • Department of Thoracic SurgeryPeking Union Medical College, Chinese Academy of Medical Sciences
  • Baozhong Li
    • Department of Thoracic SurgeryPeking Union Medical College, Chinese Academy of Medical Sciences
  • Sheng Chang
    • Renmin Hospital, Wuhan University
  • Junting Wan
    • Department of Thoracic SurgeryPeking Union Medical College, Chinese Academy of Medical Sciences
  • Kang Shao
    • Department of Thoracic SurgeryPeking Union Medical College, Chinese Academy of Medical Sciences
  • Xuezhong Xing
    • Department of Thoracic SurgeryPeking Union Medical College, Chinese Academy of Medical Sciences
  • Xiaogang Tan
    • Department of Thoracic SurgeryPeking Union Medical College, Chinese Academy of Medical Sciences
  • Zhen Wang
    • Department of Thoracic SurgeryPeking Union Medical College, Chinese Academy of Medical Sciences
  • Meihua Xiong
    • Department of Thoracic SurgeryPeking Union Medical College, Chinese Academy of Medical Sciences
    • Department of Thoracic SurgeryPeking Union Medical College, Chinese Academy of Medical Sciences
Thoracic Oncology

DOI: 10.1245/s10434-007-9457-x

Cite this article as:
Zhang, C., Zhou, F., Li, N. et al. Ann Surg Oncol (2007) 14: 2628. doi:10.1245/s10434-007-9457-x

Abstract

Background

Increasing evidence has suggested that RhoE plays an important role in carcinogenesis and progression. However, the correlation between RhoE expression and clinical outcome in lung cancer has not been investigated.

Methods

RhoE expression was detected by immunohistochemistry on tissue microarray containing samples from 115 patients with non–small cell lung cancer with a median follow-up of 54 months.

Results

RhoE was overexpressed in the cytoplasm of lung cancer cells compared with undetectable expression of RhoE in the adjacent nontumoral cells. Patients with RhoE-negative tumors had substantially longer cancer-related survival than did patients with RhoE-positive tumors. Multivariate analysis showed that RhoE overexpression was an independent marker for cancer-related survival in the entire population after adjusting for other prognostic factors.

Conclusions

RhoE expression may serve as an unfavorable prognostic factor in patients with non–small cell lung cancer.

Keywords

Non–small cell lung cancerRhoEPrognosis

Copyright information

© Society of Surgical Oncology 2007