Poor Hormone Receptor Expression in East African Breast Cancer: Evidence of a Biologically Different Disease?
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
Few studies have examined breast cancer hormone receptor expression in Africans. We report on the hormone receptor profile of breast cancer in East Africans in the largest prospective study for this region.
Consecutive breast cancer presentations to a hospital in Kijabe (2001–2007) were included. Demographic, clinical, and test data were collected. ER/PR and Her2 testing was based on immunohistochemistry (IHC).
There were 129 subjects (median 47 years), most had invasive ductal cancer and locally advanced disease and/or metastases. ER/PR testing was done in 120: 24% had ER-positive tumours, 34% were ER- and/or PR-positive, 10% were ER-negative but PR-positive tumours, and 66% were negative for ER and PR. ER/PR positivity was not associated with stage (P = 0.28) and was not related to age, parity, menopausal status, or node metastases. Increasing tumour grade was associated with PR expression (P = 0.02) with decreasing frequency of PR positive tumours as histological grade increased; there was weak evidence of an association between grade and ER expression (P = 0.06). Of cases tested, 26.5% overexpressed Her2.
Breast cancer in Kijabe is an advanced-stage disease, comprised mainly of poorly differentiated cancers that are less likely to be hormone sensitive (across all stages of disease). ER/PR testing of all those affected by breast cancer should be supported as a global priority in cancer control. International and inter-African research collaborations are needed to allow genetic detailing of tumours in indigenous Africans to assess possible racial heterogeneity in the biology of breast cancer.
- Parkin, DM, Bray, F, Ferlay, J (2005) Global cancer statistics, 2002. CA Cancer J Clin 55: pp. 74-108 CrossRef
- Eniu, A, Carlson, RW, Aziz, Z (2006) Breast cancer in limited-resource countries: treatment and allocation of resources. Breast J 12: pp. S38-53 CrossRef
- Nyagol, J, Nyong’o, A, Byakika, B (2006) Routine assessment of hormonal receptor and her-2/neu status underscores the need for more therapeutic targets in Kenyan women with breast cancer. Anal Quant Cytol Histol 28: pp. 97-103
- Ikpatt, OF, Ndoma-Egba, R (2003) Oestrogen and progesterone receptors in Nigerian breast cancer: relationship to tumour histology and survival of patients. Cent Afr J Med 49: pp. 122-6
- Mbonde, MP, Amir, H, Schwartz-Albiez, R (2000) Expression of estrogen and progesterone receptors in carcinomas of the female breast in Tanzania. Oncol Rep 7: pp. 277-83
- Anderson, BO, Shyyan, R, Eniu, A (2006) Breast cancer in limited-resource countries: an overview of the Breast Health Global Initiative 2005 guidelines. Breast J 12: pp. S3-15 CrossRef
- Henson, DE, Chu, KC, Levine, PH (2003) Histological grade, stage and survival in breast carcinoma. Comparison of African American and Caucasian women. Cancer 98: pp. 908-17 CrossRef
- International Agency for Research on Cancer (IARC): GLOBOCAN 2002 database (accessed 03/01/2008): http://www-dep.iarc.fr
- Fregene, A, Newman, LA (2005) Breast cancer in sub-Saharan Africa: How does it relate to breast cancer in African-American women?. Cancer 103: pp. 1540-50 CrossRef
- Chu, KC, Anderson, WF (2002) Rates for breast cancer characteristics by oestrogen and progesterone receptor status in the major racial/ethnic groups. Breast Cancer Res Treat 74: pp. 199-211 CrossRef
- Chu, KC, Anderson, WF, Fritz, A (2001) Frequency distributions of breast cancer characteristics classified by estrogen receptor and progesterone receptor status for eight racial/ethnic groups. Cancer 92: pp. 37-45 CrossRef
- Siziopikou, KP, Cobleigh, M (2007) The basal subtype of breast carcinomas may represent the group of breast tumours that could benefit from EGFR-targeted therapies. Breast 16: pp. 104-7 CrossRef
- Carey, LA, Perou, CM, Livasy, CA (2006) Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study. JAMA 295: pp. 2492-502 CrossRef
- Poor Hormone Receptor Expression in East African Breast Cancer: Evidence of a Biologically Different Disease?
Annals of Surgical Oncology
Volume 15, Issue 7 , pp 1983-1988
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Hormone sensitivity
- Oestrogen receptor
- Locally advanced breast cancer
- Cancer biology
- Industry Sectors
- Author Affiliations
- 1. Africa Inland Church (AIC) Kijabe Hospital, Kijabe, Kenya
- 2. University of Auckland, Middlemore Hospital, Auckland, New Zealand
- 3. Screening and Test Evaluation Program, School of Public Health, University of Sydney, Sydney, Australia