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Prognostic Significance of the Immediate Early Response Gene X-1 (IEX-1) Expression in Pancreatic Cancer

  • Hepatic and Pancreatic Tumors
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

The immediate early response gene X-1 (IEX-1) is a stress-inducible protein that is involved in the regulation of cell proliferation and apoptosis. The aim of this study was to evaluate the prognostic significance of IEX-1 expression in pancreatic cancer.

Methods

IEX-1 protein expression was examined on paraffin-embedded specimens from 78 patients with pancreatic ductal adenocarcinoma using immunohistochemistry. The relationships between the IEX-1 expression and other clinicopathological parameters and patient survival were evaluated. A similar analysis was conducted in a subgroup of 48 patients, who underwent a macroscopically curative resection with detailed information on the pathological findings.

Results

Among 78 pancreatic cancer patients, 41 patients (53%) were positive for IEX-1 staining. In a multivariate analysis, curative operation (P < .001), pathological stage I–III (P = .001), and positive IEX-1 expression (P = .002) were significantly favorable factors for survival. In a subgroup of 48 patients undergoing a macroscopically curative surgery, IEX-1 expression was positive in 28 patients (58%). A significant negative correlation was observed between the IEX-1 expression and serosal (P = .032) or arterial (P = .040) invasion of tumors. A multivariate analysis demonstrated limited local invasion (pT1-3, P = .021), negative lymph node involvement (pN0, P < .001), and positive IEX-1 expression (P = .004) to be significantly favorable factors for survival.

Conclusions

The positive IEX-1 expression in tumor tissues may be associated with a better prognosis in pancreatic cancer. An immunohistochemical assessment of IEX-1 expression may therefore be helpful for predicting patient prognosis in this disease.

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Authors and Affiliations

  1. Department of Surgery, Kitano Hospital, Tazuke-Kofukai Medical Research Institute, Osaka, Japan

    Tetsuro Sasada MD, PhD, Hiroki Hashida MD, PhD, Michiyuki Kanai MD, PhD & Arimichi Takabayashi MD, PhD

  2. Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan

    Koichi Azuma MD, PhD

  3. Department of Pathology, Kitano Hospital, Tazuke-Kofukai Medical Research Institute, Osaka, Japan

    Tatsuya Hirai

  4. Biostatistics Center, Kurume University, Kurume, Japan

    Takashi Yanagawa PhD

Authors
  1. Tetsuro Sasada MD, PhD
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  2. Koichi Azuma MD, PhD
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  3. Tatsuya Hirai
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  4. Hiroki Hashida MD, PhD
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  5. Michiyuki Kanai MD, PhD
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  6. Takashi Yanagawa PhD
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  7. Arimichi Takabayashi MD, PhD
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Correspondence to Tetsuro Sasada MD, PhD.

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Sasada, T., Azuma, K., Hirai, T. et al. Prognostic Significance of the Immediate Early Response Gene X-1 (IEX-1) Expression in Pancreatic Cancer. Ann Surg Oncol 15, 609–617 (2008). https://doi.org/10.1245/s10434-007-9669-0

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  • DOI: https://doi.org/10.1245/s10434-007-9669-0

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