Abstract
Solid dispersion systems of telmisartan (a poorly water-soluble antihypertension drug) with biopolymer carrier chitosan have been investigated in this study. The mechanism of solubilization of chitosan for drug has been studied. In addition, the influence of several factors was carefully examined, including the preparation methods, the drug/carrier weight ratios, and the milling time. Drug dissolution and physical characterization of different binary systems were studied by in vitro dissolution test, particle size distribution, Fourier transform infrared spectroscopy, differential scanning calorimetry, powder X-ray diffractometry, and scanning electron microscopy. The results presented that the weak basic property of chitosan appeared as the main driving force for the drug dissolution enhancement. Other effects such as decreased drug crystallinity and size played a positive contributory role. Among the preparation methods, cogrinding was the best method showing strong drug amorphization, reduced particle size, and enhanced dissolution. The drug dissolution markedly improved with increasing the amount of chitosan in solid mixtures. As a result, a significant effect of chitosan increasing telmisartan dissolution has been demonstrated, and cogrinding in a roll ball mill was the best way to prepare solid dispersions, which had high degree of uniformity in drug content and had a practical application in manufacturing.
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ACKNOWLEDGMENTS
We are grateful to the Natural Science Foundation of China (No. 21006097, 21076191, and 21176222), the Science and Technology Program of Zhejiang Province (No. 2009C14001), and the Program of International S&T Cooperation (No. 2008DFR40280) for financial support.
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Zhong, L., Zhu, X., Luo, X. et al. Dissolution Properties and Physical Characterization of Telmisartan–Chitosan Solid Dispersions Prepared by Mechanochemical Activation. AAPS PharmSciTech 14, 541–550 (2013). https://doi.org/10.1208/s12249-013-9937-1
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DOI: https://doi.org/10.1208/s12249-013-9937-1