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Immunogenicity of Subcutaneously Administered Therapeutic Proteins—a Mechanistic Perspective

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Abstract

The administration of therapeutic proteins via the subcutaneous route (sc) is desired for compliance and convenience, but could be challenging due to perceived immunogenic potential or unwanted immune responses. There are clinical and preclinical data supporting as well as refuting the generalized notion that sc is more immunogenic. We provide a mechanistic perspective of immunogenicity of therapeutic proteins administered via the sc route and discuss strategies and opportunities for novel therapeutic approaches to mitigate immunogenicity.

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ACKNOWLEDGMENTS

The authors are grateful for the financial support from National Heart, Lung and Blood Institute, National Institute of Health, HL-70227, to svb.

Conflict of Interest

The authors declare that there is no financial conflict of interest.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, SUNY—University at Buffalo, 359 Kapoor Hall, Buffalo, New York, 14214, USA

    Anas M. Fathallah & Sathy V. Balu-Iyer

  2. Department of Immunology and Microbiology, SUNY—University at Buffalo, Buffalo, New York, USA

    Richard B. Bankert

Authors
  1. Anas M. Fathallah
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  2. Richard B. Bankert
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  3. Sathy V. Balu-Iyer
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Correspondence to Sathy V. Balu-Iyer.

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Fathallah, A.M., Bankert, R.B. & Balu-Iyer, S.V. Immunogenicity of Subcutaneously Administered Therapeutic Proteins—a Mechanistic Perspective. AAPS J 15, 897–900 (2013). https://doi.org/10.1208/s12248-013-9510-6

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  • DOI: https://doi.org/10.1208/s12248-013-9510-6

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