Research Article

AAPS PharmSciTech

, Volume 11, Issue 1, pp 351-355

First online:

Production and Stability Evaluation of Modified-Release Microparticles for the Delivery of Drug Combinations

  • Muhammad Naeem AamirAffiliated withFaculty of Pharmacy & Alternative Medicine, The Islamia University of Bahawalpur Email author 
  • , Mahmood AhmadAffiliated withFaculty of Pharmacy & Alternative Medicine, The Islamia University of Bahawalpur

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Abstract

Production and evaluation of novel formulations of tizanidine and tramadol microparticles was the chief purpose of this project. Microparticles of both drugs were prepared separately via temperature change method. To extend the release of formulations, ethyl cellulose was employed. Higuchi, zero-order, first-order, and Korsmeyer–Peppas kinetic models were applied to appraise the mechanism and mode of drugs release. Higuichi model was found to be best for all release profiles. Stability of microparticles at 40°C/75% RH over a 3-month duration was determined by Fourier transform infrared (FTIR), X-ray diffractometry (XRD), and drugs assay. Microparticles were compatible and stable as no significant differences were observed when subjected to drug assay, FTIR, and XRD during accelerated stability studies.

Key words

microparticles stability evaluation sustained-release (SR) combination tizanidine tramadol