Abstract
Though previous data indicate a positive association between depression and coronary heart disease, the mechanisms mediating these associations remain unclear. These prospective analyses assessed the association between history of Center for Epidemiologic Studies Depression Scale depression and possible mediators of cardiovascular risk at Year 15 of follow-up in African Americans (AA) and Caucasians (C) in the Coronary Artery Risk Development in Young Adults Study. Physiological assessments included plasma levels of low-density-lipoprotein cholestrol (LDL), high-density-lipoprotein cholestrol (HDL), total cholesterol, triglycerides and fasting glucose, diabetes and blood pressure. Behavioral risk factors included alcohol consumption, smoking, physical activity, and body mass index (BMI). AA’s showed significant associations between history of depression and diabetes that did not exist in Cs and AA women had significantly more episodes of depression than any other group. However, associations of depression with smoking, BMI, and physical activity were consistent across groups in the expected direction. HDL-cholesterol was positively and LDL-cholesterol inversely associated with depression in Cs, which was unexpected. These data indicate that in this still healthy cohort, there are already associations between depression and factors that predispose to cardiovascular risk.
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Abas, M., Hotopf, M., & Prince, M. (2002). Depression and mortality in a high-risk population. British Medical Journal, 181, 123–128.
Ariyo, A. A., Haan, M., Tangen, C. M., Rutledge, J. C., Cushman, M., Dobs, A., et al. (2000). Depressive symptoms and risks of coronary heart disease and mortality in elderly Americans. Circulation, 102, 1773–1779.
Bachorik, P. S., & Albers, J. J. (1986). Precipitation methods for quantification of lipoproteins. Methods in Enzymology, 129, 78–100.
Barefoot, J. C., Brummett, B. H., Helms, M. J., Mark, D. B., Siegler, I. C., & Williams, R. B. (2000). Depressive symptoms and survival of patients with coronary artery disease. Psychosomatic Medicine, 62, 790–795.
Davidson, K., Jonas, B. S., Dixon, K. E., & Markovitz, J. H. (2000). Do depression symptoms predict early hypertension incidence in young adults in the CARDIA study? Archives of Internal Medicine, 160, 1495–1500.
Department of Health, Education, and Welfare. Food and Drug Administration. (1974). Proposed establishment of product class standard for detection or measurement of glucose. Federal Register, 39(126), 24136–24147.
Dyer, A. R., Cutter, G. R., Liu, K. Q., Armstrong, M. A., Friedman, G. D., Hughes, G. H., et al. (1990). Alcohol intake and blood pressure in young adults: The CARDIA Study. Journal of Clinical Epidemiology, 43, 11–13.
Ford, E. S., Giles, W. H., & Dietz, W. H. (2002) Prevalence of the metabolic syndrome among U.S. adults: Findings from the Third National Health and Nutrition Examination Survey. JAMA, 287, 356–359.
Friedewald, W. T., Levy, R. I., & Fredrickson, D. S. (1972). Estimation of the concentration of low-density lipoproteinn cholesterol in plasma, without use of the preparative ultracentrifuge. Clinical Chemistry, 18, 499–502.
Friedman, G. D., Cutter, G. R., Donahue, R. P., Hughes, G. H., Hulley, S. B., Jacobs, D. R., et al. (1988). CARDIA: Study design, recruitment, and some characteristics of the examined subjects. Journal of Clinical Epidemiology, 41, 105–116.
Jacobs, D. R., Hahn, L. P., & Haskell, W. L. (1989). Validity and reliability of short physical activity history: CARDIA and the Minnesota Heart Health Program. Journal of Cardiopulmonary Rehabilitation, 9, 448–459.
Jonas, B. S., Franks, P., & Ingram, D. D. (1997) Are symptoms of anxiety and depression risk factors for hypertension? Longitudinal evidence from the National Health and Nutrition Examination survey I Epidemiologic Follow-up Study. Archives of Family Medicine, 6, 43–49.
Jonas, B. S., & Mussolino, M. E. (2000). Symptoms of depression as a prospective risk factor for stroke. Psychosomatic Medicine, 62, 463–471.
Knox, S. S. (2002). Psychosocial factors in cardiovascular disease: Implications for therapeutic outcomes. Expert Review of Pharmacoeconomics Outcomes Research, 2, 139–151.
Lesperance, F., Frasure-Smith, N., Talajic, M., & Bourassa, M. G., Circulation 2002, 105(9), 1049-1053.
Penninx, B. W., Beekman, A. T., Honig, A., Deeg, D. J., Schoevers, R. A., van Eijk, J. T., et al. (2001). Depression and cardiac mortality. Archives of General Psychiatry, 58, 221–227.
Radloff, L. S. (1977). The CES-D Scale: A self-report depression scale for research in the general population. Applied Psychological Measurement, 1, 385–401.
Reiff, M., Schwartz, S., & Northridge, M., (2001). Relationship of depressive symptoms to hypertension in a household survey in Harlem. Psychosomatic Medicine, 63, 711–721.
Shinn, E. H., Poston, W. S., Kimball, K. T., St Jeor, S. T., & Foreyt, J. P. (2001). Blood pressure and symptoms of depression and anxiety: a prospective study. American Journal of Hypertension, 14, 660–664.
Slein, M. W., Cori, G. T., & Con, C. F. (1950). A comparative study of hexokinase from yeast and animal tissues. Journal Biological Chemistry, 186, 763–780.
Steffens, D. C., Helms, M. J., Krishnan, R. R., & Burke, G. L. (1999). Cerebrovascular disease and depression symptoms in the Cardiovascular Health Study. Stroke, 30, 2159–2166.
Stern, S. L., Dhanda, R., & Hazuda, H. P. (2001). Hopelessness predicts mortality in older Mexican and European Americans. Psychosomatic Medicine, 63, 344–351.
Wagenknecht, L. E., Burke, G. L., Perkins, L. L., Haley, N. J., & Friedman, G. D. (1992). Misclassification of smoking status in the CARDIA Study: A comparison of self-report with serum cotinine levels. American Journal of Public Health, 82, 33–36.
Warnick, G. R. (1986). Enzymatic methods for quantification of lipoprotein lipids. Methods in Enzymology, 129, 101–123.
Warnick, G. R., Benderson, J., & Albers, J. J. (1986). Dextran sulfate-Mg++ precipitation procedure for quantitationofhigh-density-lipoprotein cholesterol. ClinicalChemistry, 28, 1379–1388.
Wassertheil-Smoller, S., Applegate, W. B., Berge, K., Chang, C. J., Davis, B. R., Grimm, R., et al. (1996). Change in depression as a precursor of cardiovascular events. Archives of Internal Medicine, 156, 553–561.
Wulsin, L. R., Vaillant, G. E., & Wells, V. E. (1999). A systematic review of the mortality of depression. Psychosomatic Medicine, 61, 6–17.
Yan, L. L., Liu, K., Matthews, K. A., Daviglus, M. L., Ferguson, T. F., & Kiefe, C. I. (2003). Psychosocial factors and risk of hypertension: The Coronary Artery Risk Development in Young Adults (CARDIA) Study. JAMA, 290, 2138–2148.
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Knox, S., Barnes, A., Kiefe, C. et al. History of depression, race, and cardiovascular risk in cardia. Int. J. Behav. Med. 13, 44–50 (2006). https://doi.org/10.1207/s15327558ijbm1301_6
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DOI: https://doi.org/10.1207/s15327558ijbm1301_6