Introduction
Increased pulse wave velocity (PWV), a marker for aortic stiffness, has been linked to worse outcome such as heart failure. This potent marker can be accurately assessed with velocity-encoded MRI according to the transit-time method (Grotenhuis. JMRI 2009). Whether an increase in PWV translates in early diastolic dysfunction in diabetic patients remains unexplored.
Purpose
Evaluate the association between PWV and diastolic function indices in patients with diabetes type1 (DM1).
Methods
First normal values for age-related PWV were determined. Twenty-five healthy volunteers (age range 18-65years) were recruited and PWV-values of the total aorta were assessed with velocity-encoded MRI using a 1.5T MRI scanner (Philips, Best, the Netherlands). Linear regression between PWV and age defined normal values.
Next, PWV was assessed in 17 consecutive DM1 patients (mean age 48±8years). PWV was defined increased when the age-related value exceeds the normal value by 2×standard error (SE). Patients underwent subsequent 2D echocardiography for assessment of conventional diastolic function indices (isovolumetric relaxation time (IVRT), transmitral early (E) and atrial (A) peak filling velocities, E/A-ratio, E-deceleration time (DT)). Color-coded tissue Doppler imaging was applied to the 4-chamber view to determine mean mitral annulus velocity (E’). Furthermore, longitudinal speckle tracking strain analysis using apical 4-/2-/3-chambers views was performed to derive advanced diastolic indices [peak transmitral E-wave to strain rate during isovolumic relaxation (SRIVR)] and left atrium (LA) systolic strain. Subsequently, ratios of peak transmitral E-wave to mean E’ (E/E’) and of peak transmitral E-wave to strain rate during isovolumic relaxation (E/SRIVR) were calculated.
Results
Normal PWV age-relation was determined by linear regression in volunteer data: PWV=A×AGE+B, with A±SE=0.03±0.01m/s/year and B±SE=3.70±0.46m/s. In 17 DM1 patients, significant correlation was found between PWV and SRIVR and LA strain (Figure 1). A total of 7 patients showed increased age-related PWV. Mean PWV and echocardiographic diastolic function indices for patients with increased PWV (n=7) and for patients with normal PWV (n=10) are presented in Table1. Interestingly, conventional echocardiographic indices were similar between both patient groups whereas advanced diastolic function indices SRIVR, E/SRIVR and LA strain were significantly different (Table 1).
Conclusions
In patients with DM1, increased PWV is correlated with advanced diastolic function indices determined by speckle tracking strain analysis. Increased MRI PWV may translate in early left ventricular diastolic dysfunction.
Acknowledgement
Funded by Netherlands Heart Foundation (Project UL 2009-4548).
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van Schinkel, L.D., Auger, D., van Elderen, S.G. et al. Association between pulse wave velocity from velocity-encoded MRI and advanced diastolic function indices assessed by speckle tracking strain analysis in Diabetes Mellitus type 1. J Cardiovasc Magn Reson 13 (Suppl 1), P63 (2011). https://doi.org/10.1186/1532-429X-13-S1-P63
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DOI: https://doi.org/10.1186/1532-429X-13-S1-P63