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DNA confinement drives uncoating of the HIV Virus

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Abstract

The enzyme reverse transcriptase converts single-stranded RNA molecules into double-stranded DNA molecules inside mature HIV viral capsids. We present a model for the uncoating of the HIV virus where the capsid uncoating process is driven by the confinement force exerted on the capsid wall porduced to the double-stranded DNA generated by reverse transcriptase.

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References

  1. J. Kindt, S. Tzlil, A. Ben-Shaul, W. Gelbart, Proc. Natl. Acad. Sci. USA 98, 13671 (2001)

    Article  ADS  Google Scholar 

  2. J. Gopal, S. Hong-Zhou, A. Knobler, W. Gelbart, RNA 18, 284 (2012)

    Article  Google Scholar 

  3. B.K. Ganser, S. Li, V.Y. Klishko, J.T. Finch, W.I. Sundquist, Science 283, 81 (1999)

    Article  ADS  Google Scholar 

  4. G. Mirambeau, S. Lyonnais, R.J. Gorelick, RNA. Biol. 7, 724 (2010)

    Article  Google Scholar 

  5. KrishnamoorthyG. Krishnamoorthy, B. Roques, J.L. Darlix, Y. Mely, Nucleic Acids Res. 31, 5425 (2003)

    Article  Google Scholar 

  6. A.E. Hulme, O. Perez, T.J. Hope, Proc. Natl. Acad. Sci. USA 108, 9975 (2011)

    Article  ADS  Google Scholar 

  7. C.A.S.A. Minetti, Proc. Natl. Acad. Sci. USA 25, 14719 (2003)

    Article  ADS  Google Scholar 

  8. N. Hud, K. Downing, Proc. Natl. Acad. Sci. USA 798, 14925 (2001)

    Article  ADS  Google Scholar 

  9. V. Bloomfield, Biopolymers 44, 269 (1997)

    Article  Google Scholar 

  10. V.B. Shah, C. Aiken, J. Vis. Exp. 8, 3384 (2011)

    Google Scholar 

  11. H. Roos, R. Bruinsma, G. Wuite, Nat. Phys. 6, 733 (2010)

    Article  Google Scholar 

  12. J. Lidmar, L. Mirny, G.D. Nelson, Phys. Rev. E 68, 051910 (2003)

    Article  ADS  Google Scholar 

  13. T.T. Nguyen, I. Rouzina, B.I. Shklovskii, J. Chem. Phys. 112, 2562 (2000)

    Article  ADS  Google Scholar 

  14. A. de Marco, A.M. Heuser, B. Glass, H.G. Krusslich, J.A. Briggs, J. Virol. 86, 13708 (2012)

    Article  Google Scholar 

  15. W. Wang, N. Naiyer, M. Mitra, J. Li, M. Williams, I. Rouzina, R. Gorelick, Z. Wu, K. Musier-Forsyth, Nucleic Acids Res. 42, 7145 (2014)

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA

    I. Rouzina

  2. Department of Physics and Astronomy; Department of Chemistry and Biochemistry, University of California, Los Angeles, CA, 90095, USA

    R. Bruinsma

Authors
  1. I. Rouzina
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  2. R. Bruinsma
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Correspondence to I. Rouzina.

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Rouzina, I., Bruinsma, R. DNA confinement drives uncoating of the HIV Virus. Eur. Phys. J. Spec. Top. 223, 1745–1754 (2014). https://doi.org/10.1140/epjst/e2014-02223-x

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  • DOI: https://doi.org/10.1140/epjst/e2014-02223-x

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