Abstract
The effect of the treatment of hydrogel matrices based on allyl-substituted chitosans and formed by laser stereolithography in supercritical carbon dioxide (SC-CO2) on their surface polarity and mechanical characteristics was studied. Treatment in a flow mode increased the mechanical stability of the materials due to the effective extraction of the low-molecular components and oligomers. The surface polarity of the matrix decreased, improving its biocompatibility. The hydrogel matrices treated in SC-CO2 have no cytotoxic activity, due to which they can be used in tissue engineering.
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Original Russian Text © A.E. Lazhko, K.N. Bardakova, B.S. Shavkuta, S.N. Churbanov, M.A. Markov, T.A. Akopova, O.O. Parenago, A.M. Grigoryev, P.S. Timashev, V.V. Lunin, V.N. Bagratashvili, 2017, published in Sverkhkriticheskie Flyuidy. Teoriya i Praktika, 2017, Vol. 12, No. 3, pp. 70–81.
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Lazhko, A.E., Bardakova, K.N., Shavkuta, B.S. et al. Supercritical Fluid Treatment of Three-Dimensional Hydrogel Matrices Obtained from Allylchitosan by Laser Stereolithography. Russ. J. Phys. Chem. B 12, 1144–1151 (2018). https://doi.org/10.1134/S1990793118070072
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DOI: https://doi.org/10.1134/S1990793118070072