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Sulfur-containing components of supercritical garlic extracts and their synthetic analogs as potential biocides

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Abstract

We have shown that a specific component of supercritical (SC) garlic extract and some synthetic disulfide analogs are active as antimicrobials. In the course of this study, six compounds (diallyl disulfide, 1-propenylallyl disulfide, methylallyl disulfide, diallyl trisulfide, 2-vinyl-4H-1,3-dithiin, and 3-vinyl-4H-1,2-dithiin) were isolated from SC garlic extract and identified. Also, two novel sulfoxide-containing garlic analogs were synthesized. All isolated and synthetic substances were tested as potential antimicrobials against gram-positive bacteria Bacillus cereus, Mycobacterium smegmatis, and Micrococcus luteus and gram-negative bacteria Pseudomonas aurantiaca. Diallyl disulfide and diallyl trisulfide exhibited the best activity against both gram-positive and gram-negative bacteria.

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Authors and Affiliations

  1. State Plant of Medicinal Drugs Federal State Unitary Enterprise, Moscow, Russia

    D. Yu. Zalepugin, N. A. Til’kunova, I. V. Chernyshova & A. L. Mulyukin

Authors
  1. D. Yu. Zalepugin
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  2. N. A. Til’kunova
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  3. I. V. Chernyshova
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  4. A. L. Mulyukin
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Correspondence to D. Yu. Zalepugin.

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Original Russian Text © D.Yu. Zalepugin, N.A. Til’kunova, I.V. Chernyshova, A.L. Mulyukin, 2012, published in Sverkhkriticheskie Flyuidy: Teoriya i Praktika, 2012, Vol. 7, No. 4, pp. 72–81.

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Zalepugin, D.Y., Til’kunova, N.A., Chernyshova, I.V. et al. Sulfur-containing components of supercritical garlic extracts and their synthetic analogs as potential biocides. Russ. J. Phys. Chem. B 7, 843–848 (2013). https://doi.org/10.1134/S1990793113070154

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  • DOI: https://doi.org/10.1134/S1990793113070154

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