Abstract
The effects of crystalline silicon (Si) nanoparticles covered with gold and silver on the viability and state of cellular organelles of cultured human peripheral blood lymphocytes were investigated. After interaction with Si nanoparticles covered with gold (Si/Au) or with silver (Si/Ag), the reactive oxygen species in cells increased, but their viability was not decreased. The Si/Au nanoparticles decreased functional activity of lysosomes and mitochondria, while Si/Ag decreased the functional activity only of mitochondria. It is concluded that modification of a surface with gold or silver results in a reduction of biocompatibility of crystalline silicon nanoparticles.
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Abbreviations
- ROS:
-
reactive oxygen species
- NP:
-
nanoparticles
- MIF:
-
mean intensity of fluorescence
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Original Russian Text © A.N. Shubenkov, S.B. Korovin, E.R. Andreeva, L.B. Buravkova, V.I. Pustovoy, 2014, published in Tsitologiya, 2014, Vol. 56, No. 7, pp. 511–515.
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Shubenkov, A.N., Korovin, S.B., Andreeva, E.R. et al. Modification of silicon nanoparticle surface with gold or silver attenuates its biocompatibility in vitro. Cell Tiss. Biol. 8, 384–388 (2014). https://doi.org/10.1134/S1990519X14050083
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DOI: https://doi.org/10.1134/S1990519X14050083