Abstract
The influence exerted by the conditions of the synthesis of dextran phosphate hydrogels in the orthophosphoric acid–urea system on their functional composition and swellability in water was studied. The main parameters of the polymer network, namely, the mean molecular mass of segments between cross-linking points, the pore size, and the cross-linking density, were determined. Samples of prospidin immobilized on dextran phosphate hydrogels were prepared, and the kinetics of the cytostatic release into phosphate buffer solution (pH 7.4) was studied in relation to the functional composition and parameters of the polymer network of the support. The prospidin release from dextran phosphate hydrogels is due both to diffusion processes and to breakdown of the polymer network of the hydrogel.
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References
Encyclopedia of Controlled Drug Delivery, Mathiowitz, E., Ed., New York: Wiley, 1999, vol.1.
Peppas, N.A., Bures, P., Leobandung, W., and Ichikawa, H., Eur. J. Pharm. Biopharm., 2000, vol. 50, no. 1, pp. 27–46.
Van Dijk-Wolthuis, W.N.F., Macromolecules, 1995, vol. 28, pp. 6317–6322.
Maia, J., Polymer, 2005, vol. 446, pp. 9604–9614.
De Smet, L., Ceelen, W., Remon, J.P., and Vervaet, C., Sci. World J., 2013, paper 720858, pp. 1–21.
Yurkshtovich, T.L., Solomevich, S.O., Golub, N.V., et al., Colloid J., 2014, vol. 76, no. 5, pp. 628–636.
Bychkovski, P.M., Yurkshtovich, T.L., Golub, N.V., et al., Pharm. Chem. J., 2013, vol. 47, no. 7, pp. 387–392.
Corbridge, D.E.C., Phosphorus: Chemistry, Biochemistry, and Technology, Boca Raton: CRC, 2013.
Geller, B.E., Geller, A.A., and Chirtulov, V.G., Prakticheskoe rukovodstvo po fizikokhimii voloknoobrazuyushchikh polimerov (Practical Guide on Physical Chemistry of Fiber-Forming Polymers), Moscow: Khimiya, 1996.
Peppas, N.A. and Merrill, E.W., J. Polym. Sci. Polym. Chem., 1976, vol. 14, pp. 441–457.
Jong, S.J., van Eerdenbrugh, B., van Nostrum, C.F., et al., J. Control. Release, 2001, vol. 71, pp. 261–275.
Ferreira, L., Gil, M.H., and Dordick, J.S., Biomaterials, 2002, vol. 23, pp. 3957–3967.
Peppas, N.A., Hydrogels in Medicine and Pharmacy, Boca Raton: CRC, 1986, vol.1.
Yurkshtovich, T.L., Golub, N.V., Yurkshtovich, N.K., et sal., Russ. J. Appl. Chem., 2012, vol. 85, no. 11, pp. 1771–1779.
Elyashevich, G.K., Bel’nikevich, N.G., Vesnebolotskaya, S.A., Polym. Sci., Ser. A, 2009, vol. 51, pp. 550–553.
Samchenko, Yu.M. and Ul’berg, Z.R., Kolloidn. Zh., 1996, vol. 58, no. 2, pp. 240–243.
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Original Russian Text © S.O. Solomevich, P.M. Bychkovskii, T.L. Yurkshtovich, N.V. Golub, 2016, published in Zhurnal Prikladnoi Khimii, 2016, Vol. 89, No. 8, pp. 1054−1061.
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Solomevich, S.O., Bychkovskii, P.M., Yurkshtovich, T.L. et al. Influence of the properties of modified dextran hydrogel polymer network on the kinetics of the release of prospidin antitumor agent. Russ J Appl Chem 89, 1302–1308 (2016). https://doi.org/10.1134/S1070427216080140
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DOI: https://doi.org/10.1134/S1070427216080140