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The role of mercury in the processes of vital activity of the human and mammalian organisms

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Abstract

Mercury belongs to one of the most common heavy metals that have high biological activity in relation to human and animal cells. However, the physiological role of mercury in the metabolism of eukaryotic cells is still unclear. The given review provides current information on certain properties of mercury, the mechanisms of penetration of Hg (II) inside cells, its genotoxic and cytotoxic effects, as well as the role of mercury in the induction of autoimmune processes involving production of autoantibodies to the nucleolar protein fibrillarin.

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  1. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia

    V. V. Barygina, A. S. Aref’eva & O. V. Zatsepina

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Original Russian Text © V.V. Barygina, A.S. Aref’eva, O.V. Zatsepina, 2009, published in Ekologicheskaya Khimiya, 2009, Vol. 18, No. 4, pp. 189–201.

Victoria Valerievna Barygina, PhD student, Department of Biology, Lomonosov Moscow State University. Scientific areas of focus: cell biology, confocal microscopy, mobile properties of nucleolar proteins in normal and stress conditions.

Alla Sergeevna Aref’eva, junior research scientist in Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences. Scientific areas of focus: cell biology, immunology, autoimmune diseases and processes, toxicology, ecology.

Olga Vladimirovna Zatsepina, Head of laboratory, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences. Scientific areas of focus: structure and functions of nucleolar proteins in normal and pathologic conditions; nucleolus as a sensor of stress exposure in human cells.

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Barygina, V.V., Aref’eva, A.S. & Zatsepina, O.V. The role of mercury in the processes of vital activity of the human and mammalian organisms. Russ J Gen Chem 80, 2694–2703 (2010). https://doi.org/10.1134/S1070363210130037

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