Skip to main content
Log in

Heavy metals in the mother–placenta–fetus system in bank voles under conditions of environmental pollution from copper plant emissions

  • Published:
Russian Journal of Ecology Aims and scope Submit manuscript

Abstract

Accumulation of heavy metals (Cu, Zn, Cd, and Pb) in the mother–placenta–fetus system has been studied in small mammals (based on a case study of bank voles) living under conditions of environmental pollution from copper production emissions (Middle Ural). The role of gastrointestinal and placental barriers has been assessed in translocation of the studied elements from pregnant female diets to embryos. It has been shown that, with existing environmental pollution levels, the entry of toxicants into the organisms of female individuals does not necessarily lead to significant fetal losses during pregnancy, but it may affect the quality of progeny and its vital capacity in the early postnatal period.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Amaya, E., Gil, F., Freire, C., et al., Placental concentrations of heavy metals in a mother-child cohort, Environ. Res, 2013, vol. 120, pp. 120–63.

    Article  Google Scholar 

  • Baranowska, I., Lead and cadmium in human placentas and maternal and neonatal blood in heavily polluted area, measured by graphite furnace atomic absorption spectrometry, Occup. Environ. Med., 1995, vol. 51, no. 1, pp. 229–232.

    Article  Google Scholar 

  • Benitez, M.A., Mendez-Armenta, M., Montes, S., et al., Mother–fetus transference of lead and cadmium in rats: Involvement of metallothionein, Histol. Histopathol., 2009, vol. 24, pp. 24–1523.

    Google Scholar 

  • Bezel, V.S., Belskii, E.A., and Mukhacheva, S.V., On the problem of variability in reproductive parameters of animal populations under toxic pollution of the environment, Russ. J. Ecol., 1998, vol. 29, no. 3, pp. 186–191.

    Google Scholar 

  • Bezel, V.S., Kutsenogii, K.P., Mukhacheva, S.V., et al., Elemental composition of the diets and tissues of small mammals at different trophic levels as a biological indicator of chemical pollution of the environment, Chemistry for Sustainable Development, 2007, no. 1, pp. 1–33.

    Google Scholar 

  • Diaz-Barriga, F., Carrizeles, L., Calderon, J., et al., Measurement of placental levels of arsenic, lead and cadmium as a biomarker of exposure to mixtures, in Biomonitors and Biomarkers as Indicators of Environmental Change, New York: Plenum, 1995, pp. 139–148.

    Google Scholar 

  • Dinerman, A.A., Rol’ zagryaznitelei okruzhayushchei sredy v narushenii embrional’nogo razvitiya (The Role of Environmental Pollutants in Disturbances of Embryonic Development), Moscow: Meditsina, 1980.

    Google Scholar 

  • Domingo, J.L., Metal-induced developmental toxicity in mammals: A review, J. Toxic. Environ. Health: Current Issues, 1994, vol. 42, no. 2, pp. 123–141.

    Article  CAS  Google Scholar 

  • Iyengar, G.V. and Rapp, A., Human placenta as a ‘dual’ biomarker for monitoring fetal and maternal environment, with special reference to potentially toxic trace elements: Part 3. Toxic trace elements in placenta and placenta as a biomarker for these elements, Sci. Tot. Environ., 2001, vol. 280, pp. 280–221.

    Google Scholar 

  • Lindsay, Y., Duthie, L.M., and Mcardle, H., Zinc levels in the rat fetal liver are not determined by transport across the placental microvillar membrane or the fatal liver plasma membrane, Biol. Reprod., 1994, no. 51, pp. 51–358.

    Article  Google Scholar 

  • Loiacono, N.J., Graziano, J.H., Kline, J.K., et al., Placental cadmium and birthweight in women living near a lead smelter, Arch. Environ. Health, 1992, vol. 47, pp. 47–250.

    Article  Google Scholar 

  • Mirzoev, E.B., Kobyako, V.O., Gubina, O.A., and Frolova, N.A., Responses of F1 rats to chronic exposure to small doses of cadmium in the antenatal period of development, Toksik. Vestn., 2014, no. 4, pp. 4–29.

    Google Scholar 

  • Mogil’naya, G.M. and Mogil’nyi, V.L., The gastrointestinal protective barrier, Morfologiya, 2007, no. 6, pp. 6–9.

    Google Scholar 

  • Moskvitina, N.S., Kuranova, V.N., and Savel’ev, S.V., Disturbances of embryonic development in vertebrates under conditions of technogenic environmental pollution, Sib. Ekol. Zh., 2011, no. 4, pp. 4–489.

    Google Scholar 

  • Mukhacheva, S.V., Bank vole population reproduction in a gradient of technogenic environmental pollution, Zool. Zh., 2001, vol. 80, no. 12, pp. 1509–1517.

    Google Scholar 

  • Mukhacheva, S.V., Spatiotemporal population structure of the bank vole in a gradient of technogenic environmental pollution, Russ. J. Ecol., 2007, vol. 38, no. 3, pp. 161–167.

    Article  Google Scholar 

  • Mukhacheva, S.V., and Bezel, V.S., Levels of toxic elements and functional structure in population of small mammals under conditions of technogenic pollution (with reference to the bank vole), Russ. J. Ecol., 1995, vol. 26, no. 3, pp. 212–215.

    Google Scholar 

  • Nesterkova, D.V., Vorobeichik, E.L., and Reznichenko, I.S., The effect of heavy metals on the soil–earthworm–european mole food chain under the conditions of environmental pollution caused by the emissions of a copper smelting plant, Sib. Ekol. Zh., 2014, no. 5, pp. 5–777.

    Google Scholar 

  • Osman, K., Akesson, A., Berglund, M., et al., Toxic and essential elements in placentas of Swedish women, Clin. Biochem., 2000. vol. 33, p. 131–138.

    Article  CAS  PubMed  Google Scholar 

  • Salomeina, N.V. and Mashak, S.V., Structural bases of mother–fetus relationships under chemical impact during embryonic development, Med. Obraz. Sibiri, 2012, no. 1, pp. 1–10.

    Google Scholar 

  • Shvarts, S.S., Ekologicheskie zakonomernosti evolyutsii (Ecological Patterns of Evolution), Moscow: Nauka, 1980.

    Google Scholar 

  • Stawarz, R., Formcki, G., Chrobaczynska, M., et al., Accumulation of cadmium and lead in placenta and amnion of women from upper Silesian region, Poland, J. Environ. Res. Dev., 2011, vol. 5, no. 4, pp. 871–879.

    CAS  Google Scholar 

  • Talmage, S.S. and Walton, B.T., Small mammals as monitors of environmental contaminants, Rev. Environ. Contam. Toxicol., 1991, vol. 119, pp. 119–47.

    Google Scholar 

  • Thompson, J. and Bannigan, J., Cadmium: Toxic effects on the reproductive system and the embryo, Reprod. Toxicol., 2008, vol. 25, pp. 25–304.

    Google Scholar 

  • Trubina, M.R., Vorobeichik, E.L., Khantemirova, E.V., et al., Dynamics of forest vegetation after the reduction of industrial emissions: Fast recovery or continued degradation?, Dokl. Biol. Sci., 2014, vol. 458, pp. 458–302.

    Article  Google Scholar 

  • Truska, P., Rosival, L., Balazova, G., et al., Blood and placental concentrations of cadmium, lead and mercury in mother and their newborns, J. Hyg. Epidemiol. Microbiol. Immunol., 1989, vol. 33, no. 2, pp. 141–147.

    CAS  PubMed  Google Scholar 

  • Tupikova, N.V., Analysis of reproduction and age composition of small mammal populations, in Metody izucheniya prirodnykh ochagov boleznei cheloveka (Methods of Studies on Natural Foci of Human Diseases), Moscow: Meditsina, 1964, pp. 154–191

    Google Scholar 

  • Vorobeichik, E.L., Sadykov, O.F., and Farafontov, M.G., Ekologicheskoe normirovanie tekhnogennykh zagryaznenii ekosistem (lokal’nyi uroven’) (Ecological Rating of Technogenic Pollutants in Ecosystems: Local Level), Yekaterinburg: Nauka, 1994.

    Google Scholar 

  • Ward, N.I., Watson, R., and Bryce-Smith, D., Placental element levels in relation to fetal development for obstetrically ‘normal’ births: A study of 37 elements. Evidence for effects of cadmium, lead and zinc on fetal growth, and for smoking as a source of cadmium, J. Biosoc. Res., 1987, no. 9, pp. 9–63.

    Google Scholar 

  • Zakrzewska, M., Bialoriska, D., and Sawicka-Kapusta, K., Cadmium accumulation in fetus and placenta of bank voles (Clethrionomys glareolus), Bull. Environ. Contam., 2002, no. 69, pp. 69–829.

    Article  Google Scholar 

  • Zakrzewska, M., Effect of lead on postnatal development of the bank vole (Clethrionomys glareolus), Arch. Envoron. Contam. Toxicol., 1988, no. 17, pp. 17–365.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to S. V. Mukhacheva.

Additional information

Original Russian Text © S.V. Mukhacheva, V.S. Bezel’, 2015, published in Ekologiya, 2015, No. 6, pp. 444–453.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Mukhacheva, S.V., Bezel’, V.S. Heavy metals in the mother–placenta–fetus system in bank voles under conditions of environmental pollution from copper plant emissions. Russ J Ecol 46, 564–572 (2015). https://doi.org/10.1134/S1067413615060120

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1067413615060120

Keywords

Navigation