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Identification of proteins of cardiovascular system in healthy subjects’ urine during “dry” immersion

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Abstract

We analyzed the urine proteome in 14 healthy volunteers who were subjected to 5-day dry immersion using proteomic analysis methods and bioinformatics approach. We identified nine proteins related to the cardiovascular system. It was shown that 5-day dry immersion modifies the urine proteomic profile, indicating renal, endocrine, circulatory, and metabolic changes. Most of these changes are characterized by both a very rapid development and very rapid restoration within return to normal conditions.

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Authors and Affiliations

  1. Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, 123007, Russia

    L. Kh. Pastushkova, I. V. Dobrokhotov, O. M. Veselova & I. M. Larina

  2. Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090, Russia

    E. S. Tiys

  3. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, 117977, Russia

    A. S. Kononikhin

  4. Institute Energy Problems of Chemical Physics, Russian Academy of Sciences, Moscow, 117334, Russia

    A. S. Kononikhin

  5. CNRS UMR 6214, INSERM U1083, Angers University, Angers, France

    A. M. Novosiolova, M. Coupe & M. -A. Custaud

  6. Associated French-Russian Laboratory CaDyWEC, Angers, France

    L. Kh. Pastushkova, I. V. Dobrokhotov, O. M. Veselova, A. M. Novosiolova, M. Coupe, M. -A. Custaud & I. M. Larina

  7. Moscow, Russia

    L. Kh. Pastushkova, I. V. Dobrokhotov, O. M. Veselova, A. M. Novosiolova, M. Coupe, M. -A. Custaud & I. M. Larina

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  1. L. Kh. Pastushkova
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  2. I. V. Dobrokhotov
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  9. I. M. Larina
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Correspondence to L. Kh. Pastushkova.

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Original Russian Text © L.Kh. Pastushkova, I.V. Dobrokhotov, O.M. Veselova, E.S. Tiys, A.S. Kononikhin, A.M. Novosiolova, M. Coupe, M.-A. Custaud, I.M. Larina, 2014, published in Fiziologiya Cheloveka, 2014, Vol. 40, No. 3, pp. 109–119.

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Pastushkova, L.K., Dobrokhotov, I.V., Veselova, O.M. et al. Identification of proteins of cardiovascular system in healthy subjects’ urine during “dry” immersion. Hum Physiol 40, 330–339 (2014). https://doi.org/10.1134/S0362119714030128

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  • DOI: https://doi.org/10.1134/S0362119714030128

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