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Structure of two new compounds of fluoroquinolone antibiotics with mineral acids

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Abstract

New compounds of sparfloxacin (C19H22F2N4O3, SfH) and levofloxacin (C18H20FN3O4, LevoH) with mineral acids, namely, sparfloxacinium bromide (SfH · HBr, I) and levofloxacindium diperchlorate (LevoH · 2HClO4, II), have been synthesized and characterized by X-ray diffraction. Crystallographic data are a = 7.7151(7) Å, b = 26.109(3) Å, с = 10.008(1) Å, β = 103.556(1)°, V = 1959.7(3) Å3, space group P21/n, Z = 4 for I and a = 9.727(6) Å, b = 20.440(12) Å, с = 12.286(7) Å, β = 104.327(8)°, V = 2367(2)Å3, space group P21, Z = 4 for II. The structures of these compounds are stabilized by intra- and intermolecular hydrogen bonds and π–π interaction between SfH2 + or LevoH3 2+ ions.

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Authors and Affiliations

  1. Siberian Federal University, Svobodnyi pr. 79, Krasnoyarsk, 660041, Russia

    N. N. Golovnev & A. D. Vasil’ev

  2. Kirenskii Institute of Physics, Siberian Branch, Russian Academy of Sciences, Akademgorodok 50/38, Krasnoyarsk, 660036, Russia

    A. D. Vasil’ev

Authors
  1. N. N. Golovnev
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  2. A. D. Vasil’ev
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Correspondence to N. N. Golovnev.

Additional information

Original Russian Text © N.N. Golovnev, A.D. Vasil’ev, 2016, published in Zhurnal Neorganicheskoi Khimii, 2016, Vol. 61, No. 11, pp. 1472–1475.

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Golovnev, N.N., Vasil’ev, A.D. Structure of two new compounds of fluoroquinolone antibiotics with mineral acids. Russ. J. Inorg. Chem. 61, 1419–1422 (2016). https://doi.org/10.1134/S0036023616110073

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  • DOI: https://doi.org/10.1134/S0036023616110073

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