Skip to main content
SpringerLink
Log in

Effect of albumin and water-soluble analogs of vitamins E, Q, and K on the free-radical fragmentation of phospholipids

  • Radiation Chemistry
  • Published:
High Energy Chemistry Aims and scope Submit manuscript

Abstract

The effects of trolox C, ubiquinone Q0, phthicol, and bovine serum albumin (BSA) on the free-radical fragmentation of dimiristoyl phosphatidylglycerol (DMPG) in model membranes subjected to the action of γ-radiation have studied. It has been found that ubiquinone Q0 and phthicol more efficiently (by a factor of ∼1.8–1.9) than trolox C (by a factor of ∼1.5) decrease the radiation-chemical yield of dimiristoyl phosphatidic acid (DMPA), the molecular product of DMPG fragmentation. BSA exerts a protective effect on the fragmentation of DMPG in a dose-dependent manner; at a lipid to protein ratio of 30: 1, the yield of DMPA is decreased by a factor of 2.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Stark, G., Biochim. Biophys. Acta, 1991, vol. 1071, no. 2, p. 103.

    Article  CAS  Google Scholar 

  2. Yurkova, I.L., Usp. Khim., 2012, vol. 81, no. 2, p. 175.

    Article  CAS  Google Scholar 

  3. Halliwell, B. and Gutteridge, J.M.C., Free Radicals in Biology and Medicine, Oxford: Oxford Univ. Press, 2012.

    Google Scholar 

  4. Burlakova, E.B. and Khrapova, N.G., Usp. Khim., 1985, vol. 54, p. 1540.

    Article  CAS  Google Scholar 

  5. Roche, M., Rondeau, P., Singh, N.R., Tarnus, E., and Bourdon, E., FEBS Lett., 2008, vol. 582, no. 13, p. 1783.

    Article  CAS  Google Scholar 

  6. Fieser, L.F., J. Biol. Chem., 1940, vol. 133, p. 391.

    CAS  Google Scholar 

  7. Bangham, A.D., Standish, M.M., and Watkins, M.M., J. Mol. Biol., 1965, vol. 13, no. 1, p. 238.

    Article  CAS  Google Scholar 

  8. Vaskovsky, V.E., Kostetsky, E.Y., and Vasendin, I.M., J. Chromatogr., 1975, vol. 114, no. 1, p. 129.

    Article  CAS  Google Scholar 

  9. Barber, D.J., Radiat. Res., 1978, vol. 74, no. 1, p. 51.

    Article  CAS  Google Scholar 

  10. Olshuk, V.N., Melsitova, I.V., and Yurkova, I.L., Chem. Phys. Lipids, 2014, vol. 177, p. 1.

    Article  Google Scholar 

  11. Davies, M.J., Forni, L.G., and Willson, R.L., Biochem. J., 1988, vol. 255, no. 2, p. 513.

    CAS  Google Scholar 

  12. Schuchmann, M.N., Bothe, E., von Sonntag, J., and von Sonntag, C., J. Chem. Soc., Perkin Trans. 2, 1998, vol. 4, p. 791.

    Article  Google Scholar 

  13. Pototskaya, T.V., Shadyro, O.I., and Yurkova, I.L., High Energy Chem., 2004, vol. 38, no. 1, p. 2.

    Article  CAS  Google Scholar 

  14. Simic, M. and Hayon, E., Biochem. Biophys. Res. Commun., 1973, vol. 50, no. 2, p. 364.

    Article  CAS  Google Scholar 

  15. Burkitt, M.J. and Milne, L., FEBS Lett., 1996, vol. 379, p. 51.

    Article  CAS  Google Scholar 

  16. Franchi, P., Lucarini, M., Pedulli, G.F., Valgimigli, L., and Lunelli, B., J. Am. Chem. Soc., 1999, vol. 121, no. 3, p. 507.

    Article  CAS  Google Scholar 

  17. Hawkins, C.L. and Davies, M.J., Biochim. Biophys. Acta, 2001, vol. 1504, p. 196.

    Article  CAS  Google Scholar 

  18. Galantai, R., Bardos-Nagy, I., Modos, K., Kardos, J., Zavodszky, P., and Fidy, J., Arch. Biochem. Biophys., 2000, vol. 373, no. 1, p. 261.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Belarussian State University, ul. Leningradskaya 14, Minsk, 220030, Belarus

    I. V. Mel’sitova

  2. Research Institute of Physicochemical Problems, Belarussian State University, ul. Leningradskaya 14, Minsk, 220030, Belarus

    I. L. Yurkova

Authors
  1. I. V. Mel’sitova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. I. L. Yurkova
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to I. L. Yurkova.

Additional information

Original Russian Text © I.V. Mel’sitova, I.L. Yurkova, 2015, published in Khimiya Vysokikh Energii, 2015, Vol. 49, No. 3, pp. 159–163.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Mel’sitova, I.V., Yurkova, I.L. Effect of albumin and water-soluble analogs of vitamins E, Q, and K on the free-radical fragmentation of phospholipids. High Energy Chem 49, 133–137 (2015). https://doi.org/10.1134/S001814391503011X

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S001814391503011X

Keywords

Search

Navigation